Expression of Concern: Abstracts (2024)

Theory of Bio-Energy Transport in the Protein Molecules and its Applications in Physical Medicines

Pang X.F.

Institute of Life Science and Technology and Institute of Physical Elcreon, University of Electronic Science and Technology of China, Chengdu 610054, China

Objectives: Because adenosine triphosphate (ATP) are attached often on the proteins, thus we established new mechanism and theory of transport of bio-energy, which is released from hydrolysis reaction of ATP molecules, that transport along the protein and results in the variations of structure of proteins, then the bio-energy transport results in the variations of states and features of animals. Then it is necessary to investigate the changes of their hearth, this means that it has widely applications in physical medicines.

Methods: Applying new Pang's theory of bio-energy transport and structure of protein molecule research these changes.

Results: Because Pang's theory are different from other models, then Pang's soliton has a high lifetimes at 300K, which can transport over several hundreds of amino acid residues, it is real carrier, which are confirmed in the experimental of infrared spectra and Raman spectrum in acetanilide and collagen. Therefore, Pang's theory is correct. Thus we use it to explain and elucidate clearly the mechanisms and characterizations of changes of many biological and physiological phenomena in physical medicine, such as the infrared instruments and electromagnetic devices.

Conclusions: These studies promote greatly developments of physics, biophysics, physical medical instruments.

Acknowledgements: National “973”project of China for financial support (No: 2007CB936103).

The Affect of Environment Electromagnetic Field Irradiated By High-Voltage Transmission on the Health of Human and Animals

Pang X.F.

Institute of Life Science and Technology and Institute of Physical Elcreon, University of Electronic Science and Technology of China, Chengdu 610054, China

Objectives: It is necessary to investigate influence of environment electromagnetic fields (EMF) irradiated by the high-voltage transmission lines (HVTL) on the health of human and animals because EMFs are widely distributed in our environments.

Methods: We measured the changes of functions of brain, heart and muscle in animals using bioelectromagnetic instruments and methods as well epidemiological investigations for 1,400 peoples in Sichuan, Beijing etc., in which we measured also variations of physiological features of peoples live in domain of HVTL. The changes of functions of brain, heart and muscle electrical information and memory function are inspected by EGI system 200 Brain electrical information instrument and multi-channel physiological signal system.

Results: We obtained that the strengths of electromagnetic field of HVTL are depressed with decreasing their height from 7,000V/m and 0.1G to 300V/m 0.01G. EMFs result in memory loss, distracted, increase in blood fat, increases of chronic diarrhea, anemia and incidence of hoarseness symptoms, it depresses the incidence of leukopenia and thrombocytopenia. But its influences on hearth of women are smaller than another, EMF of HVTL can change the properties of the images of brain, heart and muscle electrical information of the animals.

Conclusions: EMF of HVTL influence the hearth of human and body.

Acknowledgements: The authors would like to acknowledge the National “973” project of China for financial support (grate No: 212011CB503701).

Optimization of Ultrasonic-assisted Extraction of Polysaccharides from Trichosanthin and Antioxidant Activities in Vitro

MA D.L.¹, Du H.R.², Wen Z.S.¹, Liu A.P.¹, Wang L.¹, Zheng Y.G.¹, Li J.¹

¹School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China; ²Hebei Chemical and Pharmaceutical College Department of pharmaceutical Engineering, Shijiazhuang, China

Objectives: Trichosanthin (TCS) is a Chinese herbal medicinal that has shown hepatoprotective effects with anti-inflammatory, anti-oxidants, and antiviral activity. The objective of this study is to optimized the ultrasonic-assisted extraction of polysaccharides from TCS and then studied the antioxidant capacity of the extracted polysaccharides.

Methods: On the basis of single factor experiments, the Box-Behnken experiment analyzed and optimized the ultrasonic-assisted extraction of polysaccharides from TCS by response surface methodology. The antioxidant activity of the extract's polysaccharides was then determined including the DPPH free radicals and scavenging activities against hydroxyl (˙OH), superoxide anion (˙O²⁻) and total antioxidant reactivity.

Results: The optimum conditions upon ultrasonic extraction were as follows: ultrasonic temperature 52^°C, ultrasonic time 44min and water-to-material ratio 23mL/g. Under optimum conditions, the extraction of the polysaccharides was 9.37±0.45mg/g. There were significant differences in total antioxidant reactivity, superoxide anion resistance reactivity, hydroxyl radical resistance reactivity, and the contents of polysaccharides.

Conclusions: The polysaccharides could be as a good antioxidant agent in different foods, cosmetic and pharmaceutical formulations.

Acknowledgements: The modern system of agricultural technology innovation team project of TCM in Hebei province (No. 7000120081), administration of traditional Chinese medicine of Hebei province (No. 2017105).

Effect of Blood Lipid, hom*ocysteine and Cardiac Function with Hydroxychloroquine on SLE Patients During Pregnancy

Liu E.L.¹, Zhou Y.X.², Chen M.¹, Li J.¹, Zhang D.H.¹

¹The Department of Obstetrics and Gynecology, Tang Shan Gongren Hospital affiliated to Hebei Medical university, He Bei Province, China; ²The Department of Rheumatology and Immunology, Tang Shan Gongren Hospital affiliated to Hebei Medical University, He Bei Province, China

Objectives: To investigate the effect to blood lipid, hom*ocysteine and cardiac function on SLE patients with hydroxychloroquine during pregnancy.

Methods: 61 pregnancy cases with SLE were randomly divided into two groups – the 31 cases study group with hydroxychloroquine plus hormone therapy and 30 cases control group with hormone therapy. The blood lipid, hom*ocysteine and cardiac function change were analysed in the two groups.

Results: The study group total cholesterol (TC), three glycerol (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and hom*ocysteine (Hcy) were lower than the control group, there was statistical difference between two groups; Serum Hcy, TC, TG and LDL were positively correlated with SLEDAI score. Serum Hcy level was positively correlated with TC, TG and LDL; Heart function between the two groups had no obvious change.

Conclusions: In patients with SLE pregnancy using hydroxychloroquine could significantly improve lipid metabolism, and has little effect on cardiac function and could effectively improve the glucose and lipid metabolism, reduce the risk of cardiovascular disease and SLEDAI score.

Acknowledgements: Supported by a project grant from the Science and Technology Department of Hebei Province (Grand No. 162777190).

Ameloblastomas Growth was Mediated by the Notch Signaling Through the Cell Cycle

Li W.C., Zu W., Ruan N., Lv G.H., Tian Y., Guan H.J., Zhang Y.C., Lin Y., Zhao M.Q.

Dentistry Department, Chifeng University Affiliated Hospital, Chifeng, China

Objectives: To detect the roles of theNotchsignaling pathway in ameloblastomas, expression of Notch1, P21, cyclinD1 and CDK1 was analyzed in ameloblastoma as well as in dental follicle tissues.

Methods: 5 dental follicle tissues and 15 ameloblastomas were detected immunohistochemically with antibodies against Notch1, P21, cyclinD1 and CDK1.

Results: Immunoreactivity for Notch1, P21, cyclinD1 and CDK1 was detected predominantly in odontogenic epithelial cells near the basem*nt membrane in ameloblastomas and in dental follicle tissues. The levels of immunoreactivity for Notch1, cyclinD1 and CDK1 were slightly higher in ameloblastomas than in dental follicle tissues. P21 immunoreactivity in ameloblastomas was significantly lower than that in dental follicle tissues.

Conclusions: Expression of Notch1, P21, cyclinD1 and CDK1 in dental follicle tissues and ameloblastomas suggests that these signaling molecules regulate cell survival and growth in normal and neoplastic odontogenic tissues by mediating growth factor signals. Increased expression of Notch1, cyclinD1 and CDK1 in ameloblastomas may participate in oncogenesis of odontogenic epithelium by activating the Notchsignaling pathway.

Acknowledgements: Supported by a project grant from the Inner Mongolia Natural Science Foundation of China (Grand No. 2016MS0808).

The Study of Attention Training for Healthy Youth by Somatosensory Game

Yang C.H.¹, Liu S.F.^1,2, Lee P.S.³

¹Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan; ²COOKY'S Digital Park Co., Ltd, Kaohsiung, Taiwan³Department of Occupational Therapy, I-Shou University, Kaohsiung, Taiwan

Objectives: Somatosensory game is popular topic and it plays somatosensory games can promote physical fitness. However, relevant research related to technology concerning with improving attention level still a challenge.

Methods: We used multiple baselines across – subject designs and multiple probe designs of single subject research design. In baseline phase, participants were assessed their attention level without playing somatosensory game or other attention training program. In intervention phase, participants began to receive somatosensory game for 30minutes as attention training, after training attention the participants were measured again.

Results: In maintenance phase participants stop attention training program but were assessed by the Ruff 2 & 7 Selective Attention Test in each of three days. The mean scores of Ruff 2 & 7 Selective Attention Test for three participants were as follows: 422.0, 486.3, 477.7; 393.5, 457.0, 449.7; 350.0, 397.7, 392.3. The Ruff 2 & 7 Selective Attention Test scores of all participants were improved by visual analysis; and the Ruff 2 & 7 Selective Attention Test scores of three participants in the maintenance phase have maintained effectiveness of the intervention.

Conclusions: We use somatosensory fishing games, and as a reference for the following clinical studies.

The Expression and Regulation of HOXB3 in Placenta of Patients with Hypertensive Disorder Complicating Pregnancy

Ren S.X., Zhang D.H., Liu E.L., Yang Y.

Tangshan Gongren Hospital affiliate to North China University of Science and Technology, Tangshan, He Bei Province, China

Objectives: To investigate the expression and regulation of HOXB3 in placenta of patients with hypertensive disorder complicating pregnancy.

Methods: Forty patients with hypertensive disorder complicating pregnancy who were admitted to hospital from January 2017 to March 2017 were randomly divided into 2 groups (14 in mild preeclampsia group and 26 in severe preeclampsia group). 29 cases of pregnant women who underwent cesarean section in the same period were selected as control group. The expression of HOXB3 in placenta was detected by HE staining, immunohistochemistry and Western blot. The expression of HOXB3 in placental tissue of hypertensive disorder complicating pregnancy was compared with that of control group, and the regulation of HOXB3 expression was analyzed.

Results: Compared with the control group, the expression of HOXB3 in placental tissue of patients with gestational hypertension group was significantly lower than that in the control group, with the lowest in severe preeclampsia group, followed by the mild preeclampsia group, the three groups were statistically significant (F=143.721, P=0.0001).

Conclusions: HOXB3 is low expressed in placenta of patients with hypertensive disorders of pregnancy, providing a clinical basis for studying the etiology, pathogenesis, prevention and treatment of pregnancy-induced hypertension

Acknowledgements: Supported by a project grant from the Science and Technology Department of Hebei Province (Grand No. 13130267b).

Effects of Four Different Treatments on Pregnancy Outcome in Patients with SLE

Liu E.L.¹, Zhou Y.X.², Wang L.Q.¹, Chen M.¹, Li J.¹, Wang Y.¹, Zhang D.H.¹, Zheng H.Y.¹

¹The Department of Obstetrics and Gynecology, Tangshan Workers Hospital Affiliated to Hebei Medical University, Tang Shan, China; ²The Department of Rheumatology and Immunology, Tangshan Workers Hospital Affiliated to Hebei Medical University, Tang Shan, China

Objectives: To investigated effects of four different treatments on pregnancy outcome in patients with SLE.

Methods: 182 patients with SLE pregnancy were recorded in recent years, and analyse the different treatment effects on pregnancy outcome.

Results: Multiple regression analysis showed that lupus nephritis and a PL antibody positive and SLE recurrence are predict high risk factors of pregnancy lost in patients with SLE .Lupus nephritis, anti Ro antibody, hypertension and SLE flares are predictive high risk factors of preterm. And the predictive factors of IUGR are anti-La antibody, hypertension, Raynaud's phenomenon and SLE flares. Live birth with prednisone treatment was significantly higher than those without prednisone treatment, and neonatal precocious increased. The proportion of recurrent lupus was significantly lower in SLE patients with hydroxychloroquine sulfate during pregnancy than that in those without it

Conclusions: Lupus nephritis, anti Ro/SSA antibody, APL, hypertension, Raynaud phenomenon and lupus flares and SLE exacerbations are risk factors for adverse pregnancy outcomes. Prednisone-based combined treatment is not only to reduce the recurrence of lupus, but also to improve maternal outcome of pregnancy.

Acknowledgements: Supported by a project grant from the Science and Technology Department of Hebei Province (Grand No. 162777190).

A Meta-Analysis of Pregnancy Outcomes in Patients with Lupus Nephritis

Ren S.X.¹, Liu E.L.¹, Liu Z.², Yang Y.¹

¹The department of Obstetrics and Gynecology, Tang Shan Gongren Hospital affiliated to Hebei Medical university, Tangshan, He Bei Province, China; ²The department of Rheumatology and Immunology,General Hospital affiliated to Tianjin Medical University, Tian Jin, China

Objectives: To systematically evaluate the influence of different conditions on pregnancy outcome in pregnancy complicated with lupus nephritis.

Methods: Databases CNKI, Wanfang database, CBM database, PUBMED, EMBASE, OVID were searched to collect retrospective analysis concerning the influence of different conditions on pregnancy outcome in pregnancy complicated with lupus, published between 1998 and 2017.

Results: Ten studies with 507 patients and 540 pregnancies were included. Meta analysis showed: Maternal adverse pregnancy outcomes included: 1. There was statistical significance in the rates of deteriorate of patients’ condition and preeclampsia between the pregnant patients with active lupus nephritis and those with inactive lupus nephritis; 2. There was no statistical significance in the rate of hypertension between the pregnant patients with active lupus nephritis and those with inactive lupus nephritis. Fetal adverse pregnancy outcomes included: 1. There was statistical significance in the rates of fetal loss, therapeutic abortion and premature birth between the pregnant patients with active lupus nephritis and those with inactive lupus nephritis.

Conclusions: Compared with active lupus nephritis, the pregnant patients with inactive lupus nephritis can achieve better maternal and fetal outcomes.

Acknowledgements: Supported by a project grant from the Science and Technology Department of Hebei Province (Grand No. 162777190).

Immunohistochemical Detection of Survivin, Phosphorylated Akt, and PI3K in Ameloblastomas

Li W.C., Ruan N., Lv G.H., Tian Y., Zu W., Guan H.J., Zhang Y.C., Lin Y., Zhao M.Q.

Dentistry Department, Chifeng University Affiliated Hospital, Chifeng, China

Objectives: To evaluate roles of theAktsignaling pathway in ameloblastomas, expression of Survivin, phosphorylatedAkt(pAkt), and PI3K was analyzed in ameloblastoma as well as in tooth germs.

Methods: 10 tooth germs, 30 ameloblastomas, and 4 malignant ameloblastomas were examined immunohistochemically with antibodies against Survivin, pAkt, and PI3K.

Results: Immunoreactivity for Survivin, pAkt and PI3K was detected predominantly in odontogenic epithelial cells near the basem*nt membrane in tooth germs and ameloblastomas. The levels of immunoreactivity for Survivin, pAkt and PI3K were slightly higher in ameloblastomas than in tooth germs. Plexiform ameloblastomas showed significantly higher expression of PI3K than follicular ameloblastomas. Survivin and PI3K immunoreactivity in malignant ameloblastomas was significantly higher than that in ameloblastomas without cellular variation.

Conclusions: Expression of Survivin, pAkt, and PI3K in tooth germs and ameloblastomas suggests that these signaling molecules regulate cell survival and growth in normal and neoplastic odontogenic tissues by mediating growth factor signals. Increased expression of pAkt, PI3K and Survivin in ameloblastomas may participate in oncogenesis of odontogenic epithelium by activating theAktsignaling pathway.

Acknowledgements: Supported by a project grant from the Inner Mongolia Natural Science Foundation of China (Grand No. 2016MS0808).

Bioinspired Exosome-like Nanocarrier for Targeted Delivery of miR-26a to Hepatocellular Carcinoma Model

Liang G.F.¹, Feng S.Y.¹, Feng W.P.², Li J.H.², Jing A.H.², Ma K.W.¹

¹Medical College, Henan University of Science and Technology, Luoyang, 471023, Henan, China; ²School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, Henan, China

Objectives: As an endogenous nanovesicle from cells, exosomes are expected to become new kind of drug delivery systems for various molecules such as nucleic acid-based drugs. However, normal cells release relatively low quantities of exosomes, and purification of mass production remains challenging. Here, we developed bioinspired exosome-like nanocarrier that targeted deliver miRNA to the tumor tissue.

Methods: The miR-26a loaded exosome-like nanocarriers were fabricated by the breakdown of engineered platelets using a serial extrusion through different pore diameter filters (1, and 0.45μm). Then, delivery effect of the nanovesicles was assessed by invitro and invivo.

Results: These platelet-derived nanovesicles have similar appearance and characteristics with the exosomes but have about 200-fold higher production yield. In vitro, miR-26a loaded nanovesicles showed natural targeting ability of tumor cells and induced HepG2 cell death in a dose-dependent manner. In vivo, experiments in mice model showed that the miR-26a loaded nanovesicles accumulate to tumor tissue and reduce tumor growth significantly. Furthermore, compared with miR-26a loaded exosomes, miR-451 loaded nanovesicles showed similar invivo antitumor activity.

Conclusion: The studies indicate that the bioengineered nanovesicles can serve as promising vector for effectively deliver miRNAs to treat malignant tumors.

Conclusions: The studies indicate that the bioengineered nanovesicles can serve as promising vector for effectively deliver miRNAs to treat malignant tumors.

Acknowledgements: Supported by projects grant from the National Natural Science Foundation of China (U1404824, 81741147) and Young Backbone Teacher Project of Henan Provincial Universities (2015GGJS-049).

The Role of HMGB1 in Hypoxia Induced Mitochondrial Biogenesis in Hepatocellular Carcinoma

Liu Y.¹, Zheng H.Y.²

¹Department of Gastroenterology, first affiliated hospital of Gannan Medical University, Ganzhou, China; ²Gannan Medical University,Ganzhou, China

Objectives: We found hepatocellular carcinoma HepG2 cells exhibit increased proliferation during hypoxia, but the potential mechanisms remains incompletely understood.

Methods: Loss of function strategy was applied to investigate the effect of HMGB1 on mitochondrial biogenesis in hypoxia microenvironment. The expression of mitochondrial biogenesis related genes were detected by Western blot. Mitochondrial depolarization and ROS production were performed with JC-1 and MitoSOX red staining, respectively. Mitochondrial DNA (mtDNA) copy number was measured by RT-PCR, cellular ATP levels were performed using ATP assay kit. Mitochondrial density and morphology were determined by transmission electron microscopy (TEM). Cellular apoptosis was measured by using FITC Annexin V apoptosis detection kit.

Results: Compared with control group, silencing of HMGB1 in hypoxic HepG2 cells resulted in a significant decline in PGC-1α activation and mitochondrial biogenesis,flow cytometry analysis showed that mitochondrial ROS generation significantly increased and mitochondrial membrane potential remarkably reduced, mtDNA copy number and ATP production were obviously decreased. TEM demonstrated swollen, rounded mitochondria and decrease in mitochondrial density. As a consequence of the metabolic derangements in the absence of HMGB1 and mitochondrial biogenesis, there was a significant increase in apoptosis.

Conclusions: HMGB1 induced new mitochondria formation by activating mitochondrial biogenesis, maintain and restore mitochondrial function under hypoxia microenvironment.

Acknowledgements: Supported by a project grant from Natural Science Foundation of China (Grant No. 81660406).

Evaluation of Hemostatic, Wound Healing and Antimicrobial Properties of Active Fraction from Chromolaena odorata

Wang Y., Tan Y.F., Zhang H., Zhang J.Q., Li Y.B., Lyu C.Z.

Hainan Medical University, Haikou, P.R. China

Objectives: Screen the active fraction from Chromolaena odorata and assess its hemostatic, wound healing and antimicrobial properties.

Methods: The active fraction was screened out by preliminary hemostatic activity test in rabbits. The hemostatic effect of the active fraction was measured and evaluated with the bleeding time of the rabbit ear artery and the coagulant time of the rabbit blood as the indexes. Skin injury model in rats was established to evaluate the promotion effect of the fraction on wound healing. The antimicrobial activities of the fraction against two Gram-positive and three Gram-negative bacteria were assessed by using the plate dilution method.

Results: The 30% ethanol eluate is the active fraction, which shows evident hemostatic effect on the bleeding time in rabbit invivo while unobvious procoagulant activity invitro. Remarkablewound healing effects of this active fraction on rats were observed. Antibacterial activity of the fraction was exhibited against some clinical isolated bacteria, especially the Gram-negative bacteria.

Conclusions: The 30% ethanol eluate fraction from C. odorata can decrease the bleeding time, accelerate the wound healing process and has certain antibacterial activity against the tested bacteria in clinic invitro.

Acknowledgements: Supported by a project grant from key science and technology project of Hainan Province (Grant No. ZDXM20130060).

Cyber Incivility and Negative Affect: The Moderating Effects of Personality Traits and Workload

Zou J.¹, Yan Y.²

¹School of Information Management, Central China Normal University, Wuhan, China; ²Department of Psychology, School of Philosophy, Wuhan University, Wuhan, China

Objectives: Existing research has focused mainly on face-to-face occurrences of incivility, a few recent studies have suggested that incivility also can be experienced online, the latter has been termed cyber incivility and refers to uncivil behaviors and comments manifested through information and communication technology. This study aims to investigate daily experiences of cyber incivility among employees who use e-mail (cyber incivility) for work. Further, we examined within-person relationships and its boundary conditions between day-level incivility via work e-mail (cyber incivility) and employee emotional outcomes.

Methods: Using a daily diary design, we examined effects of daily cyber incivility on end-of-work negative affect and explored the role of individual personality traits and organizational workload. Data collected over 10 consecutive workdays from 72 employees were analyzed using hierarchical linear modeling.

Results: Results showed that daily cyber incivility positively predicted end-of-work negative affect while controlling for before-work negative affect. The relationship was stronger for people with high neuroticism, and people experiencing low chronic workload. Theoretical and practical implications, limitations, and future research directions are discussed.

Acknowledgements: Supported by “Financially supported a project grant from by self-determined research funds of CCNU from the colleges’ basic research and operation of MOE” (Grand No. CCNU15A06146).

Effect of daily Workplace Civility on Employee Psychological Well-being: The Role of Positive Emotions

Yan Y., Li T.

Department of Psychology, School of Philosophy, Wuhan University, Wuhan, China

Objectives: The science of workplace civility is just beginning to take off. Workplace civility are low-level and ambiguous in their intent, individuals who engage in civility do so because it is “the right thing to do”, with no intention to benefit the target or organization. This study aimed to investigate the mechanism underlying the relationships among workplace civility, positive emotions and psychological well-being based on the broaden-and-build theory. Examining and understanding the mechanisms of workplace civility may help us successful promote civility interventions.

Methods: Using a daily diary design, we examined effects of daily workplace civility on end-of-work psychological well-being and explored the role of individual positive emotions. Data collected over 10 consecutive workdays from 56 employees were analyzed using hierarchical linear modeling.

Results: Results showed that daily workplace civility may be a springboard for more intense positive emotions. Research has demonstrated the benefits of such positive emotions for those who engage in them. Daily workplace civility positively predicted end-of-work positive emotions, while positive emotions were associated employee psychological well-being and fully mediated the link between workplace civility and employee psychological well-being. Theoretical and practical implications, limitations, and future research directions are discussed.

Acknowledgements: Supported by “Research on the Humanities and Social Sciences of the Ministry of Education in 2017” (Grand No. 17YJA190013).

Rectal Stromal Tumors Treated with Sunitinib as First-Line Neoadjuvant Therapy Resulting in Complete Pathological Response

Zhuang W.Y.¹, Qu F.¹, Liu N.¹, Sun X.T.², Yan X.¹, Guo H.Q.¹, Zhang C.N.³, Gan W.D.¹

¹Department of Urology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Zhongshan Road 321, 210008, Nanjing, China; ²Department of General Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Zhongshan Road 321, 210008, Nanjing, China; ³IJinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Nanjing University School of Medicine, Nanjing University, Nanjing, China

Objectives: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and rectal GISTs account for approximately 5% in all GISTs.

Methods: In our center, Sunitinib was used in two cases of rectal GISTs with germline mutation of Kit exon 11.

Results: For the first patient, after the targeted treatment of 22months, a surgery was performed and the en bloc excised tumor was found to be composed of hyaline connective tissue with neither CD34 nor CD117 staining, and no viable tumor cells were identified in the whole specimen. The patient continued with Sunitinib treatment after surgery for 2weeks. After 9months of follow-up, he showed no signs of recurrence. For the second patient, after 3-week treatment of Sunitinib, the maximum tumor diameter has shrunken by 38.6%, enabling the performance of R0 resection and the post-operation pathological section indicated pCR. After 9months of follow-up, no evidence of the tumor was found.

Conclusions: First-line neoadjuvant therapy with sunitinib received complete pathological response in two patients with Rectal stromal tumors.

Acknowledgements: This work was supported by a grant from National Natural Science Foundation of China (ID:81572512).

Effects of Artificial Diets on Life History Parameters of Chrysopa pallens Adults

Wang J., Wang M.Q., Liu C.X., Zhang L.S., Chen H.Y.

Key Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Objectives: Research progress is reported on two artificial diets for the adult green lacewing Chrysopa pallens. The primary objective of this study was to evaluate the effects of artificial diets, based on yellow mealworm (Tenebrio molitor) protein, on life history parameters of C. pallens, and on that basis, to design a suitable artificial diet for mass rearing of green lacewings.

Methods: Adults were provided with diets contained 15 and 10 parts of yellow mealworm defatted powder, respectively. Soybean aphids Aphis glycines were used as a control to assess the life history parameters.

Results: Results revealed that artificial diets did not negatively affect offspring egg hatch and survival rate of adults. Adult longevity and the reproductive phase of C. pallens were prolonged, while oviposition rate and fecundity declined. The artificial diet containing the lowest quantity of T. molitor protein was most effective.

Conclusions: It indicates that further improvement of the mealworm-based diet is necessary. The diet cannot serve as a standalone food source for the lacewing species in this study. Perhaps, the best advantage would be to use either artificial diet to extend the lifespan of adults during periods of aphid shortage or during cold storage.

Acknowledgements: Supported by project grants from National Key R&D Program of China (Grand No. 2017YFD0201000) and International Cooperation of Agriculture of China (Grand No. 2016-X48).

Effects of Astragaloside (As IV) on the Apoptosis, Autophagy and Inflammatory Factors of Myocardial Cells with Bone Marrow Mesenchymal Stem Cells (BMSCs) Induced 5-azacytidine Transplantation in Myocardial Infarction Rats

Hu J.H., Jia J., Zhao J.M., Jin H., Wang Q.P., Lu J., Jin L.M., Hou Q., Li F., Zhao Y., Cao J.

Research Center, Gansu University of Chinese Medicine, Lanzhou, China

Objectives: To investigate apoptosis, autophagy and inflammatory factors of myocardial cells with BMSCs induced 5-azacytidine transplantation in myocardial infarction rats.

Methods: 40 rats were randomly divided into four groups: sham group, control MI group, 5-aza MI group and 5-aza+As IV MI group. The MI model was created by permanent ligation on the left descending coronary artery. After surgery, BMSCs induced with 5-aza were injected at four sites in the peri-infarct zone. 5-aza+As IV MI group: The induced BMSCs were labelled with 5-aza and AS IV transplantation into the infarct zone of myocardial infarction rats. Four weeks after cell therapy, the infarcted heart tissue sections and ultrastructure of infarcted myocardium were observed by HE staining and transmission electron microscopy; the expression levels of apoptosis factor (Caspase-3), autophagy factor (Beclin-2) and inflammatory factor (IL-3, IL-6 and TNF-α) were tested by immunohistochemistry.

Results: Compared with the control MI group, the infarct size decreased; the expression levels of Caspase-3, Beclin-2, IL-3, IL-6 and TNF-α decreased in the 5-aza MI group and 5-aza+As IV MI group. Compared with the 5-aza MI group, the expression levels of Caspase-3, Beclin-2, IL-3, IL-6 and TNF-α reduced in the 5-aza+As IV MI group.

Conclusion: BMSCs were induced to 5-aza combined with AS IV can reduce apoptosis, autophagy and inflammatory factors.

Acknowledgements: Supported by a project grant from the National Nature Science Foundation of China (Grand No. 81260597).

Splenic Apoptotic Lymphocytes Derived from Modified PUVA Treatment Induce the Differentiation of Peripheral Blood Mononuclear Cells into Regulated Dendritic Cells Stimulated by Interleukin-4 and Granulocyte Macrophage Colony Stimulating Factor which Can Stimulate the Foxp3⁺Treg Production

Zhou L.¹, Pan L.C.¹, Su X.Z.¹, Shi X.J.¹, Du G.S.², Meng X.¹, Zheng Y.G.², Xia Z.³, Wei Y.X.⁴, Xiao W.², Liu Z.J.⁴, Kong X.R.⁴

¹Department of Hepatobiliary Surgery, PLA General Hospital, Beijing 100853, China; ²Department of Hepatobiliary Surgery, Institute of Organ Transplantation, PLA 309th Hospital, Beijing 100091, China; ³Department of Zhantansi, PLA 309th Hospital, Beijing 100034, China; ⁴Beijing Key Laboratory of Immunology Regulation Organ and Transplantation,Organ Transplant Institute of PLA, PLA 309th Hospital, Beijing 100091, China

Objective: To investigate effect of modified PUVA treated splenic lymphocytes (mPUVA-SP) on regulated dendritic cells (regDCs) induction and the regulation of the immature DCs (imDCs) on Foxp3+Treg production.

Methods: Isolated PBMCs induced to DCs with IL-4 and GM-CSF were divided into 4 groups. The imDCs collected for FCM at 6th days, meanwhile, the imDCs in other groups co-cultured with mPUVA-SP (m-ecpDCs), SP (Sp-DCs) and TNF-α (mDCs) for FCM after 24h. The m-ecpDCs and Sp-DCs co-cultured with CD4+T cell derived from MACS, and then detection the phenotype of CD4, CD25 and Foxp3.

Results: Apoptotic rates of mPUVA-SP at early stage was 95.33±3.03%. The expression of CD11c, CD1a, CD80, CD83, CD86 and HLA-DR were increased at 6days. After co-culture, phenotype in m-ecpDCs was no obvious difference compared with imDCs (P>0.05) and down-regulated significantly (p<0.05) compared with others. The level of TGF-β and IL-10 in m-ecpDCs up-regulated significantly compared with other group (p<0.05), but the lever of IL-2 and INF-γ were dramatically lower (P>0.05). The CD4+T cell co-cultured with m-ecpDCs displayed higher expression of CD25 and Foxp3 (p<0.05), and up-regulated TGF-β (p<0.05) and IL-10 (p<0.05) compared with those co-cultured with Sp-DCs.

Conclusion: mPUVA-SP can maintain imDCs presented a similar effect with regDCs in the Foxp3+Treg production from CD4+T cells.

Acknowledgements: Supported by the National Natural Science Foundation of China (NSFC) from China (NO. 81502376), Beijing Natural Science Foundation (NO. 7172201), 2018 Beijing Nova program of Science and Technology (NO. xx2018063) to X.M. and 2018 Outstanding Youth Foundation of P.L.A general hospital, and the 309th hospital foundation (2016MS-003).

MicroRNA Expression Profiling of Traditional Chinese Medicine-Based Damp-Heat Syndromes of Chronic Hepatitis B

Wen L., Jiang C., Su Y., Wu W.J., Liu X.Y., Wan T.J., Yan D., Zou X.Y., Qin B., Li B.X., Feng Q.S.

Chengdu University of Traditional Chinese Medicine, Chengdu, China

Objectives: By screening the significant differentially expressed microRNAs (SDE-miRNAs) in two top popular damp-heat syndromes of chronic hepatitis B (CHB): spleen-stomach damp-heat syndrome (SSDH) and liver-gallbladder damp-heat syndrome (LGDH), the objective and biological evidence for classification of CHB damp-heat syndromes can be provided.

Methods: miRNA microarray (Agilent 19.0) was used for expression profiling of microRNA in SSDH patients, LGDH patients and healthy controls (HCs). SDE-miRNAs in LDSV and SSDH patients compared with HCs were screened out (p<0.05, Fold change >1.2).

Results: 9 and 17 SDE-miRNAs were identified in SSDH and LGDH syndromes respectively. The syndrome-specific SDE-miRNAs were hsa-miR-1273g-3p, hsa-miR-4419b for SSDH, and hsa-miR-129-2-3p, hsa-miR-21-5p, hsa-miR-1304-3p, hsa-miR-129-1-3p for LGDH syndrome, respectively.

Conclusions: For LDSV and SSDH syndromes of CHB, the numbers and kinds of identified SDE-miRNAs were significantly different. Thus the clinical and biological basis for differentiation of CHB damp-heat syndromes were provided for the first time, providing more opportunities for stable exertion and better application of TCM efficacy and superiority in damp-heat syndrome treatment in CHB.

Acknowledgements: Supported by National Major Project of Science and Technology (Grand No. 2012ZX10005001-001), Industrial Cluster Collaborative Innovation Project of Chengdu Technology Bureau (Grand No. 2016-XT00-00033-GX) and National Postdoctoral Fund (Grand No. 2017M622984).

The Rapamycin Plus Thymalfasin can Induced the Regulated Dendritic Cells Both In Vitro and In Vivo

Pan L.C.¹, Zhou L.¹, Zhang B.¹, Ge L.X.², Li C.H.², Zheng Y.G.²

¹The Second Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China; ²Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China

Objectives: To analyze the effects of rapamycin plus thymalfasin on the induction of regulated dendritic cells (regDCs) and its’ function on tumor immunity.

Methods: Using the rapamycin plus thymalfasin intervene the HCC rat established by the DEN, analyze the expression of molecular markers and the function of immunoregulation. Furthermore, application of rapamycin plus thymalfasin to treat the DCs induced with IL-4 and GM-SCF form PBMCs, then to co-cultured with HepG2 cell lines and CD8⁺ T cell isolated from MACS for the cell proliferation assay.

Results: The DCs expression were significantly improved after the treatment of rapamycin plus thymalfasin in HCC group compared with control group (p<0.05)with the IL-10 cell up-regulated and IL-12 and CD8⁺ T down-regulated. The CD11c, 80, 86, 83 of DCs induction from PBMC increased when treated with rapamycin and thymalfasin (p<0.05), and displayed an immunoregulation on CD8+T cells when co-cultured with HepG2 cell lines. The proliferation of HepG2 was significantly inhibited after 24 to 48h with the OD value in 490nm down-regulated obviously (p<0.05). The IL-10 in the supernatant improved but the IL-12 decreased both in the rgeDCs and the co-cultured with HepG2.

Conclusions: RegDCs induced by the rapamycin plus thymalfasin display the inhibitory on the HCC proliferation invitro and invivo.

The Effect of Extracorporeal shockwave therapy (ESWT) on the osteonecrosis of the femoral head patients: a system review and meta-analysis

Su X.Z., Yue Y., Li C.B., Liao W.X., Liu J.H., Li J., Li Z.L.

Department of Sport Medicine, Chinese PLA General Hospital, Beijing, China

Objectives: The purpose of this study was to access the efficacy of extracorporeal shockwave therapy (ESWT) in the treatment of osteonecrosis of the femoral head (ONFH).

Methods: The studies were searched from the Pubmed, Embase, Cochrane library, Elsevier Science Direct and Springer using the battery of keywords. The clinical trials on the effectiveness of ESWT for ONFH were included. The clinical outcomes of ESWT were evaluated using visual analogue scale (VAS) and Harris Hip Score (HHS). After data extracted and studies quality assessment, the results were pooled and meta-analyses were performed.

Results: Six studies involving 692 hips were included in present review. ESWT proved to be no statistically effect on the pain (VAS) in 3month [Weighted mean difference (WMD) (95% confidence interval, CI)=2.56(-0.72, 5.84), P=0.13]; while in 6month [WMD(CI)=3.34(2.42, 4.27), p<0.00001] and 12month [WMD(CI)=5.43(4.42, 6.62), p<0.00001], ESWT shows significantly decrease in VAS. Moreover, compared with ARCO III, stage I shows better effect on the VAS [WMD(CI)=-1.50(-2.74, -0.26), P=0.02]. The HHS was significantly improved in 3, 6 and 12month.

Conclusion: ESWT could release the pain and improve the function of hip in the ONFH patients. Early ARCO stage of ONFH shows much more effectiveness in pain release.

TSPO Ligand YL-IPA08 Attenuates Lipopolysaccharide-Induced Depression-Like Behavior in Mice

Zhang X.Y.¹, Zhang L.M.², Li Y.F.², Mi W.D.¹

¹Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China; ²Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, China

Objectives: To investigate the effect of YL-IPA08 (a new TSPO ligand) on inflammation involved depression-like behavior in mice.

Methods: Sixty mice were assigned into four groups as control, LPS, YL-IPA08, LPS+YL-IPA08. Intracerebroventricular injection of LPS or YL-IPA08 was carried out 24h prior to behavior measurements and biochemical assays. We used open field test, tail-suspension test and forced swimming test to measure the depression-like behavior. We performed western blot and ELISA to measure the expression of TSPO and level of allopregnanolone in hippocampus. Two-way ANOVA was used to analyze the data.

Results: The intracerebroventricular administration of LPS significantly increased the immobility time in tail-suspension test and the forced swimming, while this increase was reversed by YL-IPA08 without affecting locomotor activity in open field test. Moreover, LPS increased the expression of TSPO and level of allopregnanolone in hippocampus, which were attenuated by YL-IPA08.

Conclusions: YL-IPA08 could attenuate lipopolysaccharide-induced depression-like behavior in mice. The neuroprotection of YL-IPA08 may involve the anti-depression effect of TSPO and downstream allopregnanolone. This study might provide new strategy for depression treatment.

Acknowledgements: Supported by a project grant from Nature Science Foundation of China (Grand No. 81671039).

Diagnosis of Esophageal Cancer by Raman Spectroscopy and Principal Component Analysis

Wang Q.Y., Xing L.Y., Yin X.Y., Li Z.G., Shan P., Hu S., Ma Z.H.

College of Information Science and Engineering, Northeastern University, Shenyang, China

Objectives: Esophageal cancer has been one of the most cause of disease related death because of the unhealthy dietary style. With the developing of Raman spectroscopy, it has been more and more widely used in biomedicine, biophysics, chemistry, pharmacy, and so on.

Methods: The Fourier-Transform Raman spectroscopy is used to diagnose and monitor the hemoglobin in blood. Principal component analysis (PCA) is employed to discriminate the healthy and cancer blood samples. Raman spectroscopy was acquired from 35 individuals with esophageal cancer and healthy patients.

Results: The results show that the intense of the peaks at 1,562cm⁻¹ in the spectra of healthy hemoglobin are higher than the esophageal cancer hemoglobin, and the intense of peaks at 1,639cm⁻¹ are higher than 1,591cm⁻¹ in the spectra of healthy hemoglobin, while it is just the opposite in the spectra of esophageal cancer hemoglobin. The diagnostic accuracy of Raman spectroscopy is about 95%.

Conclusions: The results show that the Raman spectroscopy is accurate and sensitive. Raman spectroscopy combined with PCA is hopeful to be a new method for the diagnosis of esophageal cancer.

Acknowledgements: This work was partly supported by the National Natural Science Foundation of China (11404054, 61601104), the Natural Science Foundation of Hebei Province (F2014501137, F2017501052), and the Fundamental Research Funds for the Central Universities (N142304003).

Detection of Breath Methane Concentration of Lung Cancer by Photoacoustic Spectroscopy and Partial Least Squares Regression

Wang Q.Y., Yin X.Y., Xing L.Y., Li Z.G., Shan P., Hu S., Ma Z.H.

College of Information Science and Engineering, Northeastern University, Shenyang, China

Objectives: Lung cancer is the leading causes of death worldwide. Ammonia plays an important role in the detection and monitoring of lung cancer. In this study, we have designed, fabricated, and characterized sensor system to detect ammonia.

Methods: The all-optical photoacoustic spectroscopy based on the tunable fiber laser is used in this experiment. In order to avoid the interference of the CO2 and H2O, the 1650.96nm absorption line for ammonia is selected. The partial least squares (PLS) is used as linear regression method. The PLS model was optimized individually by considering spectral ranges, spectral pretreatment methods.

Results: The minimum detection limit of 100ppb (signal-to-noise ratio-3) in simulated breath samples is achieved. The root mean square error of validation (RMSEP) of 0.4 and higher correlation coefficients (R) of 98%.

Conclusions: The experimental results show that real time breath gas analysis is a promising, non-invasive and simple tool that can be conducted both at home and in medical facility.

Acknowledgements: This work was partly supported by the National Natural Science Foundation of China (11404054, 61601104), the Natural Science Foundation of Hebei Province (F2014501137, F2017501052), the Fundamental Research Funds for the Central Universities (N142304003).

Research on Corrosion Resistance of Cobalt Based Alloy Used for Artificial Hip Replacement

Wu Z.Y.

Institute of equipment manufacturing, Chengdu Industrial Vocational Technical College, Chengdu, China

Objectives: To research a new kind of cobalt base alloy for artificial hip replacement, which can solve the problem that the conventional CoCrMoC as-cast alloys conforming to the ASTM F75 standard could not meet the requirement that elongation rate exceeds 8%, have good corrosion resistance.

Methods: In order to improve ductility of cast cobalt base alloys, minor amount of Nb was added to CoCrMoC alloys, fabricating a new kind of cobalt base alloy. And effect of Nb on the microstructure and electrochemical behavior were investigated by scanning electrical microscopy (SEM), Energy Disperse Spectroscopy (EDS). The best heat treatment rules were chosen by analyzing the phase diagram and a series of experiments with optical microscopy and X-ray diffraction. Anode polarization curve, electrochemical impedance spectroscopy and scanning electrochemical microscopy were performed to investigate corrosion resistance of this alloy.

Results: The new kind of cobalt base alloy with the addition of Nb can minimize casting dendritic microstructure and improve ductility after solution-treated at 1,220°C for 4h, The stable phase at room temperature is austenite phase, and transformation from austenite to martensite occurs during aging at 800°C. The results shows that Nb has little effects on open circuit potential and pitting potential of CoCrMoC as-cast alloys, and open circuit potential and pitting potential in 0.14M NaCl solution are −0.4V. The addition of citrate in NaCl solution decrease open circuit potential and pitting potential, which is detrimental to corrosion resistance. A large amount of electrochemical activity points appear in as-cast CoCrMoC alloys after immersing in 0.14M NaCl solution for 30min. The addition of Nb has minor effect on electrochemical activity of surface passive film. Surface films on solution-treated cobalt-based alloys were more stable which current is about 0.1–0.5nA and no apparent current peaks appear on films in contrast to as-cast alloys. A dense and stable film has formed on the solution-treated alloys after immersing in NaCl solution for about 30min.

Conclusions: The new kind of cobalt base alloy for artificial hip replacement was researched, which can meet the requirement that elongation rate exceeds 8%, have good corrosion resistance. The best solution treatment can eliminate dendrite segregation precipitation and pitting nucleation points. Surface passive films on solution-treated alloys are more stable than as-cast alloys and electrochemical impedance of solution-treated alloys are bigger than as-cast alloys. So the new kind of cobalt base alloy can be application as hip joint implants materials.

Acknowledgements: The authors would like to thank Y. T. Cao for the help of some tests. This research was sponsored by Panzhihua. Science and technology plan projects (2015CY-G-23).

Study on Influence of Blood Logistic Situation on Medical Effect of Acute Ischemic Disease based on Background of Coordinated Development in Beijing, Tianjin and Hebei

He X.S.¹, Zhang L.G.²

¹North China Electric Power University, Baoding 071003, China; ²College of Information Science & Technology, Agricultural University of Hebei, Baoding, China

Objectives: To improve the blood logistic situation under the background of the coordinated development in Beijing, Tianjin and Hebei, to win treatment time for acute ischemic cases.

Methods: Through the improvement of blood transport and logistics system, to study the business process of current blood blank, to find out the characteristics and advantages of logistic of blood blank, so as to analyze the existing problems in the work of blood bank and make optimization recommendation, managing the classification of emergency degree on blood demand, optimizing the transportation route, studying the new logistic system, improving the maximum speed of sending blood for acute ischemic disease in Beijing, Tianjin and Hebei.

Results: From the application result of this system in March, 2016-March, 2017, the clinical mortality in patients with acute ischemic disease such as amniotic fluid embolism is decreased from 351 cases in March, 2015 to 221 cases in March, 2016. Combined with the analysis of incidence data, the application of this system in acute ischemic patient mortality is decreased by 23.61.

Conclusions: Optimizing blood logistic system can reduce the mortality of patients with acute ischemic disease effectively.

Limb Exoskeleton System Design Under Medical Rehabilitation

Zheng Y., Zhong P.S., Liu K.H., Yang K.G.

Advanced Manufacturing Technology Center of Shandong University of Science and Technology, Qingdao, Shandong 266590, China

Objectives: According to the difficult situation of the rehabilitation of stroke patients with spinal cord injury, the driving degree of human lower limb freedom can be analyzed, a treadmill walking limb exoskeletons rehabilitation system can be designed, combined with the training experience of therapists as well as the re-operation of robot to form into a whole.

Methods: To establish the five bar model and the corresponding dynamic equationof the human-machine coupling system, and the driving torque of the hip joint and knee joint is deduced, which can provide reference data for the selection of the driving motor of the corresponding joints. In order to obtain the normal human walking on a treadmill gait, by using optical motion characteristic data acquisition system to capture the feature data of the normal human walking on the treadmill, combined with the man-machine coupling system mathematical model to get the joint angle value between the hip and knee, which can be regarded as the standard reference value of patients with rehabilitation training on the treadmill.

Results: The feasibility and reliability of system can be verified through the clinical experiment of patients’ rehabilitation training, and the experimental result is in accordance with the actual condition of the patients.

Conclusions: This exoskeleton system can provide a scientific rehabilitation training platform for the stroke patients.

Construction of Evaluation Index System and Comprehensive Evaluation Model of Drug Clinical Trial Quality Management

Tian Q.

Shijiazhuang People's Medical College, Shijiazhuang, Hebei, China

Objectives: To establish an effective quality management evaluation index system of drug clinical trials and comprehensive clinical drug evaluation model.

Methods: Summarizing problems existed in the drug clinical trial in the informed consent, the implementation of the test and the laboratory examination. Discussing and giving proposal for the key links and control measures of the quality of drug clinical trials. To establish the “three level quality control” working mode, so as to improve the quality of new drug clinical trials and experience.

Results: The establishment of the comprehensive quality control system for clinical trials in hospital drug clinical trials organization is conducive to screening safe and effective drugs for the public.

Conclusions: The establishment of this evaluation system and model will help to improve the medical level of China, as well as the speed of researching and developing clinical drugs.

Research on Walking Exoskeleton Robot in Rehabilitation Training

Hu F.J., Liu J.X., Zheng Y., Zhou S.H.F., Yu Y.J.

Qingdao Huanghai University, Qingdao, Shandong, P.R. China

Objectives: With the increasing of the aging population, the number of elderly people who have lost their motor skills due to stroke disease is increasing. To solve the problem of walking obstacle and rehabilitation training for the elderly, a new robot of exoskeleton was designed.

Methods: Combining the exoskeleton robot with the wheelchair, according to the characteristics of the rehabilitation wheelchair and the exoskeleton robot, the composition and mechanism design scheme of each part was developed. According to the operation principle of pedal car, a reasonable rehabilitation training strategy is developed through the master-slave operation method. The patient with cerebral apoplexy could not only recover the ability of lower extremity motor, but also can complete the rehabilitation training process during the exercise, and also provide a convenient walking tool. In order to improve the user's participation, a multi-modality rehabilitation training control process and operation method were proposed, and the kinematics analysis of the exoskeleton were carried out. Operation environment was set based on the human body quality standards and movement characteristic to guarantee the correctness and rigor of the analysis results.

Results: According to the principle of pedaling motion, the exoskeleton robot with the function of rehabilitation training and walking were designed. The feasibility of exoskeletons movement was analyzed, and the exoskeletons movement characteristic analysis experiment was completed. Through the master-slave operation method, the follow-up of wheelchair movement to exoskeleton movement was verified.

Conclusions: Through the structure design and research of the new exoskeleton robot with the function of rehabilitation and walking, a virtual prototype of lower limb rehabilitation exoskeleton robot was established. On the basis of reasonable rehabilitation training strategy, the kinematics analysis of the exoskeleton were carried out. The feasibility and correctness of the designed rehabilitation system were verified. For the master-slave operation method, the sensitivity of the relevant sensors and their cooperation still need further experimental verification.

Research and Design of Medical Logistics Sorting System Based on RFID

Zeng S.X., Xue R., Chen J.B.

Qingdao Huanghai College, Qingdao, China

Objectives: Most logistics companies use manual sorting to complete the sorting process. However, with the rapid development of commodity economy, the demand for sorting of small quantities and varieties has also been increasing. Especially with the increase in the number of pharmaceutical products and the increase in the number of pharmaceutical products, the task of warehousing and sorting is becoming more and more complicated.

Methods: In this paper, RFID label is used to replace the bar code to study the medical storage sorting system. According to the composition and working principle of the RFID system, the automatic sorting system based on RFID is designed.

Results: According to the working principle of radio frequency identification system, an RFID tag is installed on the medicine to quickly sort the medicines.

Conclusions: The RFID tag identification method can realize the recognition, processing and automatic sorting of multi-type and over-the-horizon items, and improve the flexibility and compatibility of the sorting system through the design of a label-oriented system, so as to facilitate data statistics and drug flow track.

Acknowledgements: The research work was supported by the Science and Technology Plan Projects of Higher Education in Shandong Province No. J16LN94 and J17KB151.

Research and Design of Wearable Micro-Power Intelligent Blind Guidance System

Xue R., Zeng S.X., Liu N.

Qingdao Huanghai College, Qingdao, China

Objectives: In this paper, a wearable technology-based micro-power intelligent guide system was designed. The system is mainly composed of microprocessor, sensor module and wireless transmission module.

Methods: Use of smart GPS module, electronic map, voice broadcast, communication module to achieve real-time send and receive location data, positioning and navigation, obstacle detection and one-button help and other functions; through the microprocessor to calculate the navigation route to achieve blind travel independently, and converted to voice information; through the bottom of the shoe vibration at different locations prompted the user to achieve navigation; in addition, a piezoelectric converter is designed to convert the human pressure energy into electrical energy in the system, which can be used as part of supplementing energy supply to the module, reducing the consumption of the total power system and reducing the overall system power consumption.

Results: With this system, blind people can free their hands and increase travel safety.

Conclusions: The system has the advantages of simple structure, stable performance, easy operation, low cost, easy learning by the blind, high cost performance and broad market prospect.

Acknowledgements: The research work was supported by the Science and Technology Plan Projects of Higher Education in Shandong Province No. J17KB151 and J16LN94.

Application of PET/CT Image Texture Feature Analysis System to the Diagnosis of Brain Tumor

Xue R., Zeng S.X., Song J.

Qingdao Huanghai College, Qingdao, China

Objective: To develop a system based on PET/CT image texture feature analysis and apply it to the detection of intracranial tumor.

Method: According to the texture features of PET/CT brain image, enhancing the feature and texture and analyze the focus area automatically. Making contrasting diagnosis on 552 cases of suspected intracranial tumors in Qingdao from May, 2014 to May, 2016.

Result: Among 552 cases, 102 cases were diagnosed as intracranial tumors. The sensitivity and specificity of conventional PET/CT for diagnosing lung cancer is 70.5% and 81.1% respectively. The sensitivity and specificity of PET/CT image texture analysis system to diagnose intracranial tumor is 86.5% and 62.3% respectively.

Conclusion: The system based on PET/CT image texture feature analysis can have good effect on the diagnosis of intracranial tumor.

Acknowledgements: The research work was supported by the Science and Technology Plan Projects of Higher Education in Shandong Province No. J17KB151 and J16LN94.

Preliminary study on health education management mode implemented by college and enterprise

Jiao L.T., Liang Z.H., Yang J.

Qingdao Huanghai University, Qingdao, China

Objectives: Found the problems existing in the enterprise employees’ health management, then put forward the countermeasures from the angle of the cooperation between colleges and enterprises.

Methods: Summarize the significance of enterprise employees’ health education management, design and build its index system on the basis of the theoretical model of enterprise employee health management evaluation.

Results: Found the problems existing in the enterprise employees’ health management, then put forward the countermeasures.

Conclusions: Found the problems existing in the enterprise employees’ health management, then put forward the countermeasures from the angle of the cooperation between colleges and enterprises.

Acknowledgements: Here and now, I would like to extend my sincere thanks to all those who have helped me make this paper possible and better. This paper is the phased research result of teaching reform project of Shandong undergraduate college teaching reform in 2015 that is “ Research and practice of college and enterprise cooperative education mechanism based on unity of courtyard garden in private colleges” (Project number: 2015M083). Firstly, I am deeply grateful to my research team. Then thanks to the teachers and professors who have given me suggestions and support.

Design of Environmental Monitoring System in Operating Room

Liu P.X., Chen Y.J., Jiang B.H.

Qingdao Huanghai University, Qingdao, China

Objectives: The operating room is essential for each hospital department, it contains large amounts of harmful gases, such as disinfectant volatile gas and anesthetic emissions. The doctor and the nurse's health is threatened seriously,environmental information is collected to protect health care workers by using modern information collection technology, the system we designed will warn timely When the operating room gas quality does not meet the requirements.

Methods: The main harmful gases in the operating room are anesthetic gas, ozone, electric knife smoke, carbon dioxide and so on. In the monitoring system designed by the predecessors, most of them are added with carbon dioxide and ozone, and involve less electric knife smoke and narcotic exhaust gas. In this paper, Combined with anesthetic exhaust gas sensors and smoke sensors, an operating room environment detection system was designed. The anesthetic exhaust gas sensor mainly utilized the absorption of infrared light by the anesthetic exhaust gas sensor, and the infrared light was modulated into alternating light by emitting infrared light Operating room, to the receiving device, amplified by the signal into the microcontroller acquisition, smoke acquisition using MQ-2 sensor, after AD conversion into the microcontroller, microcontroller acquisition through the LCD demonstration.

Results: In a hospital operating room to build a test environment, after testing, the system response speed, the test results due to the use of averaging filter and other algorithms, so more accurate, less error, to fully meet the needs of the laboratory.

Conclusions: This article designed an operating room environment monitoring system. The system uses anesthetic gas detection device, electric knife smoke detection device, real-time acquisition of the operating room concentration of harmful substances in the environment when the value exceeds the set value alarm in time, the use of 4G wireless transmission technology and remote cloud server communication, The operating room environment data cloud storage and multi-terminal real-time viewing can effectively realize the real-time monitoring of operating room environment safety and can effectively reduce the harm to the medical staff.

Acknowledgements: This research was financially supported by the College Science and technology project of Shandong Province (J15LN59,J16LN75, J16LN78)and Shandong Province key research and development programs(2017GGX201004).

The Design of Online Monitoring System for Medical Cold Chain

Jiang B.H.¹, Qi Q.², Liu P.X.¹, Sun H.Y.¹

¹Qingdao Huanghai University, Qingdao, Shandong, China; ²Qingdao Binhai University, Qingdao, Shandong, China

Objectives: Vaccines and other special drugs must be stored in a refrigerated environment, otherwise easily lead to deterioration of drugs, ranging from no effect of drugs, heavy cause medical accidents, therefore, to monitor the storage environment for such special drugs is very meaningful, in previous studies, Most of them are using the wired way, only local view, with the development of the Internet big data, the use of remote cold chain environment has become possible, this paper designed a cold chain environment cloud detection system that can cold Chain environment for remote viewing. Vaccines and other special drugs must be stored in a refrigerated environment, otherwise easily lead to deterioration of drugs, ranging from no effect of drugs, heavy cause medical accidents, therefore, to monitor the storage environment for such special drugs is very meaningful, in previous studies, Most of them are using the wired way, only local view, with the development of the Internet big data, the use of remote cold chain environment has become possible, this paper designed a cold chain environment cloud detection system that can cold Chain environment for remote viewing.

Methods: This design according to the related theory of Internet of things and cloud computing, Internet of things, cloud platform, such as the new technology used to medical cold chain monitoring, to build a medical cold chain monitoring system based on cloud platform, further enhance the automation of modern medical cold chain monitoring and informatization.

Results: The test data shows that this medical cold chain online monitoring system has high accuracy, wide test range and can realize on-line monitoring function of cold chain. The medical cold chain online monitoring system can provide a new running mode for the development of modern medical cold chain monitoring.

Conclusions: A medical cold chain on-line monitoring system is designed for medical cold storage, blood bank, vaccine, organ storage and cold chain. The system can realize intelligent terminal self-organizing route acquisition and coordinator 4G for medical cold chain environment temperature and humidity information Remote transmission and overrun alarm, server cloud storage and other functions, can solve the current lack of cold chain monitoring system to promote low temperature medical cold chain automation and information technology, and greatly promote the development of modern cold chain monitoring.

Acknowledgements: This research was financially supported by the College Science and technology project of Shandong Province (J16LN78, J16LN75, J15LN59) and Shandong Province key research and development programs (2017GGX201004).

Study on the Effect of Intracranial tumor Diagnosis using Real-time Monitoring and Fault Diagnosis Technology of MRI and CT Equipment

Zheng L.^1,2, Luo Y.G.^1,2, Feng C.J.^1,2, Zhang R.B.^1,2, Shi Z.Q.³

¹Dalian Minzu University, No. 18, Liaohe West Road, Jinzhou New District, Dalian, Liaoning Province, 116600, P.R. China; ²Key Laboratory of Intelligent Perception and Advanced Control of State Ethnic Affairs Commission; ³Hebei University of Technology, Xiping Road No. 5340, Beichen District,Tianjin, 300130, P.R. China

Objectives: To establish the MRI and CT real-time monitoring and fault diagnosis system to avoid data distortion caused by the predictable failures of the system, in order to decrease the misdiagnosis rate of intracranial tumors.

Methods: The image fusion of CT and MRI technology not only can make up for their respective deficiencies, but also can play a synergistic role in morphology and function. By developing the real-time monitoring and fault diagnosis system, the failures of the MRI and CT system is predictable. To observe the effect of CT and MRI real-time monitoring and fault diagnosis system on the detection rate of intracranial tumor. In particular, atypical intracranial tumors of the clinical and imaging are complex and changeable. This system can help to amend the diagnostic parameters and improve the detection rate of intracranial tumor.

Results: Compared with the traditional technology, this system can avoid misdiagnosis caused by system failure. Especially in the diagnosis of atypical intracranial tumors, the system can improve the detection accuracy significantly.

Conclusions: This real-time monitoring and fault diagnosis system can effectively improve the diagnostic accuracy of the intracranial tumor in CT and MRI system.

Acknowledgements: This work is supported by the “Fundamental Research Funds for the Central Universities” (No. DC20150201402, No. DC201502010202), the “Natural Science Foundation of Liaoning Province” (No. 20170540205) and the “Tianjin Science and Technology Project” (No. 16KPXMSF00030).

Study on Improving the Packaging Design and Quality of Pharmaceutical Products in Online Pharmaceutical Business Platform

Zhang T., Qi X.M., Yu Z.

Qingdao Huanghai University, Qingdao, Shandong, China

Objectives: The packaging design of medicine is different from the general product. The medicine belongs to special commodity, so the packaging suppliers should know more about the medical market and they need to update their ideas. During the design process, it is more effective to focus on emotional factors to meet the psychological needs of the audience. Pharmaceutical enterprises should pay attention to the unity and consistency of packaging recognition in medical paper box so that consumers can better identify and differentiate them. It is more convenient for the promotion of corporate image, so as to increase the purchase rate. Ensure that fakes are not flowing into the market to reduce harm to patients.

Methods: 1. The pharmaceutical enterprises extract the core of pharmaceutical products selling point by collecting research data, and combine it with marketing communication strategies as the main packaging design elements to attract more consumers. On the one hand, science and technology serve the design. On the other hand, the design should have the convenience of science.

2. The drug production enterprises shall adopt safe and environmentally friendly packaging materials, which are easy to transport and carry. The anti-counterfeiting technology, such as anti-counterfeiting of barcode, identification of anti-counterfeiting, special materials and process anti-counterfeiting, packaging structure anti-counterfeiting, greatly prevent the circulation of fake and inferior medicines.

Results: Pharmaceutical companies have attached great importance to the design and quality of product packaging, and the State Drug Administration also imposed strict rules on the content of the drug packaging. This requires designers to adjust the font, font size, word spacing and pay more attention to the design details. This makes it easy for medical staff and users to read, making certain key words obvious. Packaging materials adopt new materials that are easy to transport and clean. On the original basis, they focus on the research and development, also pay attention to the product packaging form of moisture-proof, blocking light and high temperature sterilization, so as to meet the needs of consumers.

Conclusions: Medicine is a special commodity for human defense, disease and rehabilitation. The packaging design of pharmaceutical products is closely related to the quality of medicine and is directly related to human life safety. In addition, with the development of market economy, the packaging design and packaging quality of medicine are also the important factors that affect sales. Therefore, considering the characteristics of the medicine itself, the transportation risks, the transportation costs and the commercial purposes, the packaging design of pharmaceutical products is of great significance.

Study on the Effect of the Ultra-Low Temperature Online Monitoring System on the Survival Rate of Living Tissue Cells

Zhao M.L., Liu Z.Q., Cao A.X., Niu H.C.

Qingdao Huanghai University, Qingdao, Shandong, China

Objectives: sem*n, hepatocytes, placenta, bone marrow, biological samples and other special medical items need to be kept in the ultra-low temperature environment. The lack of effective monitoring of the ultra-low temperature environment has caused major accidents and economic losses, such as “Shanxi High Temperature Exposure Vaccine Event”, “Jiangsu Rabies Vaccine Incident “and so on. These incidents brought great economic losses and negative social impacts. Therefore, it is imperative to carry out real-time monitoring of low-temperature and ultra-low-temperature environments. Aiming at the current situation of cryogenic temperature research, an ultra-low temperature on-line monitoring system was designed.

Methods: A remote monitoring system with low temperature environment is designed. The system mainly consists of terminal node, sink node and host computer. The terminal node collects the information of the low temperature environment through the sensor and sends the collected information to the sink node regularly. The sink node module can display the collected information of the terminal, the temperature exceeds the short message alarm and sends the information to the host computer module, meanwhile, Of the control commands sent to the terminal node, the host computer can achieve a variety of information configuration, history query, curve report printing and a series of functions in the data transmission process using data fusion technology to reduce the amount of data transmission through the transfer to improve Transmission efficiency, the entire system uses a modular structure, based on the scene quickly set up the application system.

Results: The design of ultra-low temperature medical cold storage online monitoring system in a hospital set up a test environment was tested, the test results show that the system can measure the temperature range of −200°C to 100°C, ±0.5° error, high precision, fast response, Can upload cloud platform in real time, fully meet the needs.

Conclusions: Based on the design of the terminal node and convergence node of the remote monitoring system of ultra-low temperature freezer and the implementation of each module, an effective, convenient, fast and inexpensive ultra-low temperature medical monitoring method of cold storage temperature was designed. The system has real-time, accurate, convenient, reliable and other characteristics, will be widely used in the market.

Acknowledgements: This research was financially supported by the College Science and technology project of Shandong Province (J16LN75,J15LN59,J16LN78)and Shandong Province key research and development programs(2017GGX201004).

The Application of Digital Design Combined 3D Printing Technology in Ankle Fracture Surgery

Zhou S.F., Yu Y.J., Zheng Y., Cao C.H.J.

Qingdao huanghai college, Qingdao, China

Objectives: To investigate the clinical application of digital design combined with 3D printing technique in the treatment of ankle fractures

Methods: Select the CT data of 4 cases with ankle fractures and three-dimensionally model were established in Rhinoceros 6.0 software, then all the fractures were 3D Printed, then to define the location of the plate, the direction and length of the screw and then complete of pre-shaping steel plate.

Results: Combined with 3D printed entity model, we can use the pre-bending of the steel plate to simulating the internal fixation implant surgery, and finally the parameters such as the position of the steel plate and the direction and the length of the screw were used in the actual operation. Experiments show that the surgical process is smooth, steel plate and screw smoothly into the joint, implantation direction and length are highly consistent with the preoperative design.

Conclusions: Observe the X-ray film after surgery and found that ankle fracture reduction and satisfaction were satisfied, and the steel plate and screw were in good position. The ankle fracture model made by using 3D printing technique can be used primarily for the surgical simulation and surgical design of ankle fractures.

Evaluation of Personal Health Condition Based on Fuzzy Soft Set Theory

Kong Z.¹, Wang L.F.¹, Lu F.Q.¹, Wang L.Q.²

¹School of Control Engineer, Northeastern University At Qinhuangdao, Hebei Qinhuangdao, China; ²State Grid Liaoning Information and Communication Company, Liaoning, Shenyang, China

Objectives: Health assessment is an important means to obtain the health status of individuals, groups and society, which is the basis for successful health management, health education and health promotion. Four factors, physical health, mental health, social health and moral health, are considered to assess health.

Methods: Fuzzy soft set theory and normalization theory are used to assess evaluate heath in order to solve different disciplines of natural science and social science. After dealing with the qualitative information into quantitative information, the assessment is made by fuzzy soft set theory.

Results: Personal health condition is analyzed and quantified from physical health, mental health, social health and moral health, and health status is obtained.

Conclusions: Example indicates that the method can be used to evaluate personal health. The result is helpful for health analysis and discovering the weak aspects of person health.

Acknowledgements: This work is supported by the National Natural Science Foundation of China (Grant No. 61402088, 71401027); Natural Science Foundation of Hebei under Grant (Grant No. F2017501041, F2016501023, G2016501086). Science Research Foundation of Northeastern University at Qinhuangdao (Grant No. XNK201502).

Application of Fuzzy Soft Set Theory in Prediction of Coronary Heart Disease with Electrocardiogram Signals

Kong Z.¹, Wang L.F.¹, Lu F.Q.¹, Wang L.Q.²

¹School of Control Engineer, Northeastern University At Qinhuangdao, Hebei Qinhuangdao, China; ²State Grid Liaoning Information and Communication Company, Liaoning, Shenyang, China

Objectives: Coronary heart disease is one of the most common causes of death. Early diagnosis of coronary heart disease has important clinical and social significance. Electrocardiogram (ECG) is the earliest and most commonly used medical technology in the diagnosis of coronary heart disease. The ECG signals are analyzed to diagnose coronary heart disease.

Methods: Fuzzy soft set theory and normalization theory are used to analysis of T wave amplitude, R wave amplitude, R wave amplitude and T wave amplitude difference, R wave amplitude and T wave amplitude ratio, QRS wave amplitude of ECG signals. The final diagnosis is made by fuzzy soft set theory.

Results: Fuzzy soft set is an effective diagnosis method after clinical diagnosis and detection. And this method has obvious prediction on coronary heart disease.

Conclusions: Example indicates that the method can be used to diagnose coronary heart disease. The method is helpful for subhealth analysis of heart.

Acknowledgements: This work is supported by the National Natural Science Foundation of China (Grant No. 61402088, 71401027); Natural Science Foundation of Hebei under Grant (Grant No. F2017501041, F2016501023, G2016501086). Science Research Foundation of Northeastern University at Qinhuangdao (Grant No. XNK201502).

Study on Forming Process and Clinical Effect of Intracranial Vascular Stent

Wu X.Q.¹, Shi H.Y.¹, Wang L.H.¹, Hao R.C.²

¹Inner Mongolia University for the Nationalities, College of Mechanical Engineering, Tongliao, 028000, China; ²Beijing Polytechnic, Beijing, 10000, China

Objectives: To explore the optimal ratio of scaffold manufacturing materials and the feasibility of automization spray and EPC Process.

Methods: The scaffold material can select biocompatible SA and PVA. The two materials can be mixed and dissolved in deionized water to obtain gel materials, thus calcium chloride (CaCl2) can be used as cross-linking agent to form blood vessels. Through orthogonal experiment, analyzing nine groups of gel material experimental data of different material ratio, according to the elastic model and porosity data of gel material, the best material ratio can be selected. By using the soluble sucrose, it can make vascular type core materials and produce vascular core model, by using spray gun, it can achieve gel on the core model of the uniform spraying and cross-linking on the gel material with calcium chloride in deionized water, then the core material can be dissolved, so as to obtain hollow stent.

Results: According to the orthogonal experimental gel material, it can get the best material ratio of SA:4% (wt%), PVA:5% (wt%), CaCl2:4% (wt%), the elastic modulus of the gel material under the material ratio is 993.19kPa, and the porosity of the scaffolds is 89.23%, which can make the same morphology of vascular stent in the core shape.

Conclusions: The ratio of different materials has an important influence on the performance of the gel material, and the optimal ratio data can be obtained by the orthogonal experiment. It is feasible to realize the manufacture of hollow vascular stent by the combination of automization spray and EPC.

Acknowledgements: This work is supported by The Inner Mongolia Autonomous Region Natural Science Foundation: (2016MS0550).

Methods Study on Improvement of Hemodialysis Medical Instruments Disinfection and Clinical Effect Analysis

Shi H.Y., Wu X.Q., Wang L.H., Li L.

College of Mechanical Engineering, Inner Mongolia University for the Nationalities, Tongliao 028000, China

Objectives: To investigate the problem of disinfection in the use of hemodialysis medical instruments and to improve the dialysis equipment, so as to analyze the clinical effect.

Methods: According to the clinical needs of the hospital and analysis of the dialysis accident, the existing dialysis equipment is improved.

Results: The result can show us that the total number of chlorides, calcium, chloramine and endotoxin in the dialysis equipment is decreased by 11.2%, 9.1%, 12.8%, 1.92% and 28.4% respectively.

Conclusions: This improvement has been achieved the expected effect, which can effectively reduce the incidence of hemodialysis accidents and improve the self cleaning ability of dialysis equipment.

Extraction and Analysis of Biological Characteristics Information of Skull Diploic Vein

Wang L.H., Shi H.Y., Wu X.Q., Li L.

Inner Mongolia University for the Nationalities, College of Mechanical Engineering, Tongliao, 028000, China

Objectives: Summarizing and extracting the characteristic parameters of the diploic vein, so as to achieve the parametric design of skull diploic vein.

Methods: Using high resolution microscopic CT scanning technique to scan the skull tissue. The grayscale image of the skull tissue can be obtained. To realize the reconstruction of three-dimensional model by using skull tissue gray image of Gauss filtering and threshold segmentation. By using Avizo software to extract the distinction and skeleton radius statistics of skeleton line cavity structure, so as to identify the characteristic structure of the diploic vein. Based on the analysis and extraction of the central line and the radial interface of the main vein, a parameter model describing the sequential center line and sectional contour is proposed, which is composed of two fork tree structures and circular cross section along the axis.

Results: Through the above method, the extraction parameters of the model for diploic vein vascular space is X, vessel radius is r, node length is d, the main branch angle is θ, the branch angle is α, the sweep taper and vascular wall thickness is γ and h.

Conclusions: The main vascular model VM (Vessel model) can be expressed by (X, d’, θ,α,r’,γ,h), the corresponding small vessel model VM VM’ can be expressed by (X,d’,θ,α,r’,γ,h). Through analyzing the measurement and the induction of the model of vein reconstruction, the range of the above parameters can be acquired, which can provide the basis for the parametric design of the diploic vein.

Acknowledgements: This work is supported by The Inner Mongolia Autonomous Region Natural Science Foundation: (2016MS0550).

Analysis on the Status and Prevention of Food Borne Human Zoonosis

Chen L.Y.¹, Wang L.H.²

¹College of Animal Science and Technology, Inner Mongolia University for the Nationalities, Tongliao028042, China; ²College of Mechanical Engineering, Inner Mongolia University for the Nationalities, Tongliao 028000, China

Objectives: To study the status of human zoonosis in rural areas and to analyze the solutions according to the analysis of food borne human zoonosis in Shandong area.

Methods: Collecting and analyzing the monitoring data of food borne diseases, 32 counties of Shandong province in 2016.

Results: There are 38 town medical institutions and disease control institutions monitored in the province, and 17,561 samples are received. A total of 91 outbreaks of food borne diseases are reported throughout the year, and 979 people occurred the disease, including 54 family outbreaks, accounted for 59.34%, the patients are mainly from the catering places, totally 594 people, accounted for 60.67%. The suspected food is mainly about poultry, pork and meat products, as well as some aquatic products and so on. The pathogens are mainly Norovirus, Salmonella and Vibrio parahaemolyticus, and Vibrio parahaemolyticus.

Conclusions: Norovirus and Salmonella are the main pathogens of food borne diseases in Shandong province. Prevention and control of food borne zoonosis should be carried out from these two pathogens.

Case Study on Application of New Electronic Endoscopy in the Examination of Gastrointestinal Diseases

Yan W., Wu X.Q.

¹College of physics and electronic information engineering, Inner Mongolia University for the Nationalities, Tongliao 028000, China; ²College of Mechanical Engineering, Inner Mongolia University for the Nationalities, Tongliao 028000, China

Objectives: To examine the value of new electronic endoscopy in the diagnosis of gastrointestinal diseases.

Methods: A new electronic endoscopy we used in 26 patients with unidentified gastrointestinal diseases in the Affiliated Hospital of Inner Mongolia University by electronic endoscopy.

Results: There are no uncomfortable feelings during the examination of 26 patients. There are 21 detected cases, including 4 cases of erosive gastritis, 5 cases of duodenitis, 3 cases of Crohn's disease, 4 cases of intestinal vascular malformation, 2 cases of intestinal submucosal mass (surgery and pathology confirmed as small intestinal tumor), 3 cases of ascending colon diverticulum. The positive rate is 80.76%.

Conclusions: The operation of the electronic endoscopic examination is simple, safe and effective, which has a high diagnostic value for digestive tract diseases, especially for small intestinal diseases.

Study on the Influence of Femoral Prosthesis on the Surrounding Fractures In Artificial Hip Replacement Surgery Based on Motion Simulation

Sun W.L., Ge W.W., Han S.F., Yu X.

Qingdao huanghai college, Qingdao, China

Objectives: Through the analysis of the literature data of the fracture study of the femoral prosthesis in artificial hip arthroplasty, the significance and function of using 3d software to carry out the motion simulation was studied.

Methods: Using the search term “total hip replacement femoral prosthesis peripheral fracture influence” electronically to search CNKI database for academic journals and select the influencing factors of periprosthetic femoral fractures in artificial hip arthroplasty from 2010 to 2017, and to analyze, It summarizes the key influence factors.

Results: The main reason of intraoperative periprosthetic femur fracture during hip arthroplasty is trauma. overhaul aging treatment, patients, type of prosthesis, prosthesis fixed way and the increase of the joint activity all contribute to the risk of fracture, which is a good guidance value for periprosthetic femur fracture on clinical treatment. Find the impact and abrasion of periprosthetic femur fracture by building a three-dimensional modeling of periprosthetic femur fracture and motion simulation of flexion, exhibition, rotation, and rotation movement.

Conclusions: To avoid the periprosthetic femur fracture to being wear and fracture around after hip arthroplasty, The clinical doctors need conduct sufficient motion simulation verification to the patient before surgery and formulate reasonable operation scheme and choose the right fixed way in order to reduce postoperative discomfort and the probability of fracture around, which will help clinicians to control postoperative fracture probability and has a high clinical value.

Controllability Analysis of Drug Metabolic Networks

Wang L.F.¹, Zhang Y.L.¹, Kong Z.¹, Wang L.Q.²

¹School of Control Engineering, Northeastern University At Qinhuangdao, Hebei Qinhuangdao, China; ²State Grid Liaoning Information and Communication Company, Liaoning, Shenyang, China

Objectives: Deciphering the controllability of drug metabolism and its interaction with other cellular functions is central to biomedicine and biotechnology. Yet, understanding the controllability of drug metabolic fluxes remains elusive. We shall endeavor to explore the possible ways to quantitatively measure the extent of controllability of any drug metabolic network.

Methods: Here we present an index is chosen to quantitatively measure controllability of given drug metabolism network. To perform controllability analyses, the topological characteristics of the ensemble of networks are first quantified, including degree, shortest path length, clustering coefficient, and betweenness centrality, as well as the uncertainty associated with these and related properties.

Results: The effect of this index is analyzed mainly based on empirical studies on various classes of drug metabolism network topologies, such as random network, small-world network, and scale-free network.

Conclusions: The index can overcome some of the limitations of existing controllability concepts, and extend the methodology for controllability analysis of drug metabolism networks, from qualitative to quantitative. In addition, a small proportion of driver nodes can provide the conditions for controlling the slow dynamics of entire drug metabolic networks from a topological perspective, despite variations in network sizes and configurations.

Acknowledgements: This work is supported by Natural Science Foundation of Hebei Province of China (Grant No. F2016501023, F2017501041); Science Research Foundation of Northeastern University at Qinhuangdao (Grant No. XNK201502); National Natural Science Foundation of China (Grant No. 61402088).

Design of Medical Call System Based on CAN Field Bus Technology

Niu H.C., Zhao M.L., Liu X.L.

Qingdao Huanghai College, Qingdao, Shandong, China

Objectives: This paper has designed the medical call system based on CAN field bus technology.

Methods: The system uses industrial field bus CAN and SCM to achieve ward and nurses station and health care room and other communication links between the help and response to achieve real-time communication. In this paper, the overall system design and software and hardware design, gives the communication protocol.

Results: The actual use of results show that the system has the advantages of strong function, high reliability, low power consumption, easy installation and commissioning, has a strong practical value.

Conclusions: The design solves the problems of remote key signal transmission and system low power consumption.

Clinical Application of Automated Image Analysis System in Blood Test

Zhang H.N., Yan W.

College of Physics and Electronic Information, Inner Mongolia University for the Nationalities, Tongliao 028000, China

Objectives: To establish an automated image analysis system for blood cell test and to study the applications of the system in clinical sample tests.

Methods: Image processing technique was used to extract blood cell morphology, optical density, color and texture features, and genetic algorithm was used in feature selection. The methods were used to study the efficiency of automated image analysis system in the diagnosis of various cell classification counts or morphological abnormalities, including sensitivity, specificity, and accuracy.

Results: The automatic image analysis system showed high sensitivity, specificity and accuracy in counting the specificity of various cell or morphological anomaly detection. The correct rate of the differentiation of the various cells reached 98.72%, and the detection rate of abnormal cells reached 99.81%.

Conclusions: The system is highly sensitive in blood cell classification, counting and abnormal cell testing, and could be used in clinical blood testing.

Acknowledgements: Inner Mongolia University for Nationalities scientific research projects (NMDYB15023, NMDYB15096).

Application of 3D Gastroscopy Combined with Mechanical Arm in the Treatment of Gastric Mucosal Ulcer

Wu X.Q., Wang L.H., Shi H.Y.

College of Mechanical Engineering, Inner Mongolia University for the Nationalities, Tongliao 028000, China

Objectives: To explore the clinical treatment technique of gastric mucosal ulcer with 3D gastroscope and micromechanical arm.

Methods: 45 cases of gastric mucosal ulcer were treated with 3D gastroscopy in the affiliated Hospital of Inner Mongolia University for nationalities during December 2015 and January 2017. The short-term curative effects were recorded, such as operation time, intraoperative bleeding volume, inhibition drug spraying effect, feeding time, etc., to observe and analyze the characteristics and curative effects of this technique.

Results: All the treatments of 45 patients with gastric ulcer were successful, The short-term curative effects were recorded, such as operation time, intraoperative bleeding volume, inhibition drug spraying effect, feeding time are all better than those of the traditional surgeries.

Conclusion: The mechanical arm combined with 3D gastroscopy can reduce the difficulty of operation. And this technique has the characteristics of good curative effect and high efficiency. This method has a good prospect in the treatment of gastric ulcer.

Acknowledgements: College Scientific Research Project of Inner Mongolia Autonomous Region (NJZY18159); Inner Mongolia University for Nationalities scientific research projects (NMDYB15023, NMDYB15096).

The Present Situation and Psychological Intervention of Social Anxiety in Urban Population

Xu L.C.

Wuhan University of Technology, Wuhan, 430070, China

Objectives: To explore the status and psychological intervention of social anxiety in urban population.

Methods: A total of 86 urban people were randomly divided into observation group and control group, 43 in each group. The social anxiety measurement is carried out on all the urban crowds by using the UCLA Loneliness Scale, the Shyness Scale and the family environment scale, and the personal evaluation questionnaire is issued to carry out self-evaluation. According to the status of social anxiety in urban population, the control group had normal learning and life, and the group intervention was taken by the observation group to intervene the subjects.

Results: The social anxiety of the urban population was very significant, which had an important influence on the psychological situation of the urban population. Through psychological intervention, the scores of UCLA loneliness scale, Shyness Scale and family environment scale in the observation group were better than those in the control group, and the individual evaluation results were also higher than those in the control group. And the difference was significant (p<0.05).

Conclusions: Currently, the social anxiety of urban population is very significant. After psychological intervention, they can improve their social anxiety, improve their level of self-evaluation and increase emotional regulation.

A Study on the Relationship Between College Students’ Emotional Management Ability and Mental Health

Fan H.P.

Zhengzhou Normal University, Zhengzhou, 450044, China

Objectives: To explore the relationship between college students’ emotion management ability and mental health.

Methods: A total of 1,000 college students from four universities in our city were selected as the object of study. The emotion management ability of 1,000 college students was analyzed by means of questionnaire, and the mental health status of college students was measured with SCL-90. Result: The average scores of the five dimensions of college students’ emotional management ability are classified as follows: controlling negative vent > rational regulation > seeking outside support > controlling negative suggestion > positive remedy.

Results: The results showed that there were obvious negative correlations between the three factors and the SCL-90 factors, such as the rational control of college students, the control of negative implications and the control of negative venting. However, there is only a negative correlation between college students’ seeking outside help and interpersonal, paranoid, psychotic and depressive factors. Positive remedies were negatively correlated with the symptoms of compulsion, psychosis, and depressive factors while positive remedies and paranoia factor and hostile factor are obviously related.

Conclusions: In the investigation of college students’ emotional management ability, the five dimensions are closely related to their mental health status. Therefore, we should pay attention to the cultivation of college students’ emotional ability and encourage them to participate in some meaningful activities to improve their mental health.

Study on the Effect of Single Exercise Intervention on Students with Impaired Glucose Tolerance

Dong K.W.^1,2, Xue X.X.¹

¹Wuhan Sports University, Wuhan, 43000, China; ²Moscow State Academy of Physical Education, Moscow, Russia

Objectives: To study the effect of single exercise intervention on students with impaired glucose tolerance.

Methods: In this study, 25 patients with low glucose tolerance in a university in JX were selected as the study subjects and randomly divided into control group and observation group. In the control group, 12 cases were treated with routine motion intervention while 13 cases in the observation group were treated with single exercise intervention of moderate intensity level running. The training period was 15weeks, 6 times a week and 2h a time. And two groups of IGT students glycated hemoglobin level, waist circumference and insulin were observed and recorded.

Results: Compared with the control group, the insulin level in the observation group was significantly lower than that in the control group, and the difference between the two groups was statistically significant (p<0.05). The level of hemoglobin in the observation group was significantly lower than that of the control group, and there was significant difference between the two groups (p<0.05). The waist circumference of the observation group was significantly lower than that of the control group. There was significant difference between the two groups (p<0.05).

Conclusions: Single-phase motion intervention can effectively reverse the decrease of sugar content of college students and has certain application value.

A Study of Group Intervention on Depression in Urban College Students

Chen C.Y.^1,2

¹Wuhan University of Technology, Wuhan, 430070, China; ²Zhongnan University of Economics and Law, Wuhan, 430073, China

Objectives: To explore the intervention effect of group intervention on depression of urban college students and explore the methods of group training in colleges and universities.

Methods: In the study, 40 students with depression were selected as subjects, and they were divided into observation group and control group randomly. 49D cognitive coping group training and psychological intervention were carried out for the students in the observation group, and the normal training was taken in the control group. The intervention effects of three kinds of measuring tools, SDS, ASQ and SCSQ were compared to 7d college students before and after intervention. After six months, the SDS self-assessment scale was used to measure the return visit.

Results: There was no significant difference in depression score between the observation group and the control group before intervention (p>0.05).

Conclusions: Group intervention on depression of urban college students can obviously improve their depression and promote their mental health. Therefore, it should be actively carried out.

Study on the Effect of Sports Intervention Based on Energy Metabolism on Body Composition of Obese College Students

Dong K.W.^1,2, Xue X.X.¹

¹Wuhan Sports University, Wuhan, 43000, China; ²Moscow State Academy of Physical Education, Moscow, Russia

Objectives: To study the effect of exercise intervention under energy metabolism on obesity in obese college students and to analyze the body of obese college students.

Methods: 56 obese college students were selected as the study subjects and randomly divided into control group and observation group. In the control group, 28 cases were treated with routine exercise intervention while 28 cases in the observation group were treated with exercise intervention based on energy metabolism. And the fat degree, fat content and muscle weight of the two groups were observed and recorded.

Results: Compared with the control group, the obesity degree of the observation group was significantly lower, and there was significant difference between the two groups (p<0.05). Compared with the observation group, the fat content in the control group was relatively high, and there was significant difference between the two groups (p<0.05). The growth rate of muscle in the observation group was obviously higher than that of the control group, and there was significant difference between the two groups (p<0.05).

Conclusions: The application of exercise intervention under energy metabolism to the obesity of obese college students could effectively increase the muscle weight of college students and reduce the fat content and fat degree.

Study on the Characteristics of Energy Consumption and Metabolism During Exercise

Li Y.Y.

Wuhan Sports University, Wuhan, 430079, China

Objectives: To study the characteristics of energy consumption and substrate metabolism during exercise.

Methods: 16 female college students in a university in H province were selected as the control group, and 16 male college students were selected as the research group. The two groups of car exercise experiments with different intensity were carried out, and the energy metabolism of the body was analyzed by the gas substitution method.

Results: Compared with the control group, the total energy consumption in the observation group was significantly higher, and the difference between the two groups was statistically significant (p<0.05). The percentage of fat in the control group was significantly higher than that in the observation group (p<0.05). There was no significant difference in fat oxidation between the control group and the observation group under the same exercise intensity (p>0.05). Compared with the control group, the observation group was significantly higher glucose oxidation and two groups had statistically significant difference (p<0.05).

Conclusions: In the process of exercise, the proportion of female fat supply is significantly higher than that of men and the total energy consumption in the process of male exercise is more than that of women.

Study on the Relationship Between Exercise and Acute Myocardial Infarction in Different Time Periods

Yang S.L.

Shaanxi Normal University, Shaanxi, 710000, China

Objectives: To explore the association between different time periods and acute myocardial infarction.

Methods: In the study, 124 patients with coronary heart disease were selected as the study subjects and they were divided into observation group and control group averagely, with 62 patients in each group. The control group chose not to exercise, the observation group chose exercise and they were divided into morning exercise group and the evening exercise group. The exercise information of patients was collected by questionnaire and the relationship between different sports intensity, different movement frequency, duration of different movement, and movement in different time periods was compared with that of acute myocardial infarction.

Results: The corrected OR value of the observation group and the control group was 0.68 and the incidence of acute myocardial infarction was lower in the case of exercise. Different exercise intensity, different exercise frequency, different exercise duration and different time periods have an important impact on the occurrence of acute myocardial infarction. If the exercise intensity is high, the frequency is high and duration is long, they can prevent myocardial infarction. Compared with the control group, the observation group morning exercise group and evening exercise group correction value of OR was 0.61 and 0.57, the difference is distinct and the difference was statistically significant (p<0.05). Compared with the morning exercise group, the risk of acute myocardial infarction was 0.92.

Conclusions: The risk of acute myocardial infarction in patients with coronary heart disease with high exercise intensity, high frequency and long duration was lower. And exercise in the morning and evening had a similar protective effect on the prevention of acute myocardial infarction.

The Effect of Different Sports Methods on the Body Composition of Female College Students with Recessive Obesity

Huang P.

Physical Educational College of Jiangxi Science & Technology Normal University, Nanchang, 330013, China

Objectives: To explore the effects of different exercise patterns on the body composition of female students with recessive obesity.

Methods: According to the principle of knowledge and voluntariness, 136 female students who volunteered to participate in the investigation were selected as the research object. The IOI353 analyzer was used to screen out 48 college students with invisibility obesity, which were averagely divided into the non exercise group, the aerobic exercise group, the resistance training group and the aerobic resistance group. The non exercise group did not take any exercise, and the other groups performed 12weeks of exercise. Before exercise, 4weeks, 8weeks and 12weeks after the exercise, each body component was detected.

Results: Compared with those before the intervention, the BF % and WHR of the aerobic exercise group, the resistance training group and the aerobic resistance group were significantly decreased. In addition, the BMI of the aerobic exercise group was significantly decreased and the difference was significant (p<0.05). Compared with the control group, the BF % and WHR of the aerobic exercise group, the resistance training group and the aerobic resistance group were better than that of the control group. And BMI in aerobic exercise group was significantly better than that in control group, the difference was statistically significant (p<0.05).

Conclusions: The exercise has obvious improvement effect on the body composition of the invisible obese female college student body, which can reduce the body fat rate and improve the morphology. Different modes of movement also have an influence on their body composition, and the exercise mode can be selected reasonably in combination with their own situation.

Design of 3D Visualization System for Medical Image Based on MRA Data

Li L.F.¹, Qi M.R.²

¹Shaanxi Normal University, School of Computer Science, Xi'an 710119, China; ²Xi'an University of Science and Technology, College of Humanities and Foreign Languages, Xi'an 710054, China

Objectives: To discuss the design method of medical image 3D visualization system based on MRA data.

Methods: Using three-dimensional visualization of carotid artery as an example, the three-position reconstruction algorithm on the basis of volume rendering was discussed. And if three-dimensional carotid artery is extracted, based on this, we could combine VTK and ITK with it to construct a 3D visualization system of medical images based on MRA data by using C++.

Results: The 3D visualization system of medical image data can be read on the MRA based on DICOM images, and can be displayed completely. At the same time, a series of interactive operations can be carried out on the three-dimensional image, and three-position blood vessel segmentation and enhancement on the basis of volume rendering can be realized.

Conclusions: The medical image 3D visualization system based on MRA data can read and display 3D images, and can realize a series of interactive operations, which can achieve better blood vessel enhancement effect and carotid artery extraction. It has important function and significance for three-bit visualization of medical image.

Medical Image Segmentation Method Based on Improved Artificial Bee Colony Algorithm

Li L.F.¹, Qi M.R.²

¹Shaanxi Normal University, School of Computer Science, Xi'an 710119, China; ²Xi'an University of Science and Technology, College of Humanities and Foreign Languages, Xi'an 710054, China

Objectives: To study the application of artificial bee colony algorithm in medical image threshold segmentation.

Methods: a new image segmentation method based on improved artificial bee colony and thresholding medical image threshold segmentation method is proposed, which is variable coefficient artificial bee colony optimization algorithm (VCABC), which is used to determine n-1 optimal n level threshold on a given image. The proposed method is compared with the PSO fractional image threshold segmentation method and the ABC fractional medical image threshold segmentation method.

Results: when considering a variety of conditions, the performance of this method is better than that of other methods.

Conclusions: the improved method of combining artificial bee colony and fractional medical image threshold segmentation method is effective.

Effect of Aerobics Combined with Strength Training Intervention on Invisible Obese College Students

Liu Q.

Zhongyuan University of Technology, Henan, 450007, China

Objectives: To discuss the influence of the intervention program of strength training on the hidden obese college students on the basis of aerobics movement.

Methods: By means of the voluntary principle, 28 college students with invisibility obesity were selected from the test instruments, such as height and weight and they were randomly divided into observation group and control group, each of which was 14. The control group adopted routine training program, and the observation group adopted aerobics and strength training intervention program for 6weeks. And the physical form, physical quality and so on of the two groups of invisible obese college social workers were observed.

Results: The body composition, skinfold thickness, strength and flexibility of college students were significantly better than those in the control group. Compared with before training, the improvement effect is very obvious, and the difference is significant (p<0.05). But in the body circumference and the lung activity, the improvement was not obvious (p>0.05).

Conclusions: Aerobics combined with strength training intervention can improve the body composition of invisible obese college students, improve strength and muscle content and can improve flexibility. And the impact is very obvious.

Effect of Aerobics Movement on Cognitive Ability of Obese Adolescents

Liu Q.

Zhongyuan University of Technology, Henan, 450007, China

Objectives: To explore the influence of aerobic exercise on the cognitive ability of obese adolescents.

Methods: 56 obese adolescents were selected as the research object: 28 cases in the control group and 28 cases in the observation group. The normal learning and life were prepared for the obese adolescents in the control group and aerobics, diet and comprehensive educational intervention therapy were provided for the obese adolescents in the observation group. And the neurocognitive function of two groups of obese adolescents was assessed by multi-dimensional neuropsychological test.

Results: After comprehensive intervention of calisthenics, diet and education, the BMI, body weight, systolic blood pressure and white light reaction in the observation group were significantly better than those in the control group and the differences are significant (p<0.05). At the same time, the cognitive ability test, raven reasoning test scores were significantly better than the control group. And intuitive discrimination, similar comparison, analogy reasoning were significantly higher than the control group and the difference was statistically significant (p<0.05).

Conclusions: The comprehensive intervention of aerobics for obese adolescents can obviously improve their cognitive ability and have practical significance.

Effect of Oral Creatine on Anaerobic Sports Ability of Soccer Players

Wang C.

Xi'an Fanyi University, Xi'an, 710105, China

Objectives: To explore the effect of oral creatine on the anaerobic exercise ability of soccer players.

Methods: Twenty healthy football players in five football teams were selected as the study subjects, and they were randomly divided into observation group and control group, each of which was 10. The football players in the control group were given glucose at a rate of 5g/time, and the members of the observation group were given creatine glucose at a rate of 5g/time and the supplementation of the two groups was 5g*4, when they have their meals and before bedtime. During the period, the training of the football players is normal. And the blood lactic acid and oxygen free work of the two groups were compared.

Results: After having oral creatine, the peak of oxygen-free work of the observation group was significantly increased, which was obviously superior to the control group without oral creatine. The difference was statistically significant (p<0.05). After having oral creatine, the lactate level of 3min in the observation group was significantly lower than that in the control group after exercise, and the difference was statistically significant (p<0.05).

Conclusions: After the oral creatine is taken orally, the peak of the oxygen-free work, the explosive force and the action quality of the football player can be improved. What's more, it can increase the speed of movement fatigue recovery and it is worth popularizing.

Multiple Factor Analysis of Neuropsychology in Elderly Patients with Depression

Zhang Y.

Xi'An Pei Hua University, Xi'an, 710000, China

Objectives: To explore the multiple factors of neuropsychology in elderly patients with depression.

Methods: 64 elderly patients with depression were selected as subjects. The Geriatric Depression Scale (GDS), neuropsychological scale score and family support scale were use to analyze multiple factors of neuropsychology in elderly patients with depression.

Results: Through GDS, neuropsychological scale and family support scale, we can see that there are cognitive impairment in elderly patients with depression. It is closely related to the following three factors: the economic capacity of the family, their health status and family support level. These factors play an important role in the depression of the elderly and are the main causes of depression in the elderly.

Conclusions: There are many neuropsychological factors affecting depression in the elderly. In the prevention of the occurrence of depression in the elderly, the prevention of physical diseases should be done in time and the harmonious family relationship should be maintained. At the same time, the economic situation of elderly families should be improved.

Study on the Effect of Music Therapy on Psychological Intervention of Patients After Operation

Qin R.Y.

Shaanxi Normal University, Xi'an, 710000, China

Objectives: To explore the effect of music therapy on psychological intervention of patients after operation.

Methods: The patients were divided into the observation group and the control group on the average of 68 patients after the outpatient operation, and each of which was 10. Routine psychological nursing was given to the patients after operation in the control group and the observation group applied music therapy on the basis of routine psychological nursing. The psychological anxiety value of two groups of patients was assessed by Zung anxiety self-rating scale. At the same time, the blood pressure, pulse and pain of the two groups of patients were compared.

Results: The blood pressure, pulse and pain degree of the patients in the observation group were better than those in the control group. The psychological anxiety value of the two groups was significantly better than that of the control group (p<0.05).

Conclusions: Music therapy has important influence on psychological intervention of postoperative patients. The patient's psychological anxiety can be reduced by the use of music therapy at the same time after the patient's psychological intervention, which can reduce the psychological anxiety of the patients, improve the psychological status of the patients, help the patients to maintain the stability of vital signs and help the patients recover after operation.

Effect of Music Therapy on Relieving Depression of Teachers

Wang T.T.

Shaanxi Normal University, Xi'an, 710000, China

Objectives: To explore the role of music therapy in relieving depression of teachers.

Methods: 60 patients with depression were selected as the study subjects and they were randomly divided into two groups, with 30 patients in the observation group and 30 patients in the control group. The control group was given routine drug therapy for depression teachers, and the observation group was treated with music therapy on this basis. With the Hamilton anxiety scale and Hamilton depression rating scale, two groups of teachers depression treatment effects were measured.

Results: In the application of music therapy, the observation group of teachers has been significantly relieve depression. In the first weekend, the second weekend, the fourth weekend and the eighth weekend, the reduction rate of the observation group was significantly better than that of the control group, and the difference between the two groups was statistically significant (p<0.05).

Conclusions: In the course of the treatment of depression of teachers, the application of music therapy can alleviate the depression of teachers to a large extent and has important clinical practice significance.

Effects of Yoga Exercise on Body Shape and Cardiovascular Function of Female College Students

Zhang X.C.

Northwest University, Xi'an, 710000, China

Objectives: To explore effects of yoga exercise on body shape and cardiovascular function of female college students.

Methods: 120 female college students were selected as the study subjects and they were randomly divided into observation group and control group, with 60 participants in each group. The control group of female college students have routine life and learning while the observation group of college students have an 18 - week yoga practice. The exercise frequency is 3 times a week, 90min/times, between 50VO2max and 60VO2max, mainly including preparation activities, pose exercises and relaxation exercises after the end. And the physical form index of two groups of female students was compared.

Results: The BMI, LIVI, WHR, VEK, HR, SV, SI, CI, VPELs, MSP, MDP, AC, ETK and STR of observation group female college students were significantly better than those in the control group. The difference between the two groups was significant and the difference was statistically significant (p<0.05).

Conclusions: By means of yoga practice, the physical form of female college students can be obviously improved, and the function of losing weight can be achieved. It can also improve the cardiovascular function of female college students and the effect of exercise is very remarkable.

Research on Medical Image Segmentation Based on Fuzzy Clustering Algorithm

Li J.^1,2, Ning Y.³, Yuan Z.M.⁴, Yang C.J.⁵

¹National Key Laboratory of Air traffic Flow Management, Nanjing 211106, China; ²College of Civil Aviation, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China; ³Aid Station in 75,130 Units of the Chinese People's Liberation Army, Guigang, 537100, China; ⁴School of Medicine, Nanjing Tongren Hospital, Southeast University, Nanjing, 211102, China; ⁵National Satellite Meteorological Centre, Beijing 100081, China

Objectives: To apply the fuzzy clustering algorithm to medical image segmentation technology and analyze the application effect of the algorithm.

Methods: In this study, the application of bacterial fuzzy clustering algorithm and bacterial foraging optimization algorithm in tooth image segmentation are analyzed. Among them, bacteria fuzzy clustering algorithm is a research group, bacteria foraging optimization algorithm is a conventional group. Relevant researchers need to compare the separation index, partition coefficient and partition index of the two algorithms.

Results: Compared with the conventional group, the separation index and the partition coefficient of the experimental group were relatively high, and the two groups in the separation index and partition coefficients have a statistically significant difference (p<0.05); compared with the experimental group, the index value was higher in the conventional group, and there was significant difference between the two groups in the zoning index (p<0.05).

Conclusions: Compared with the traditional bacterial optimization algorithm, the application of the bacterial fuzzy clustering algorithm in tooth image segmentation is more remarkable.

Study on the Difference of Weight Reduction Effect Between HIIT and Persistent Aerobic Exercise for Female College Students

Zhang Y.¹, Sun L.L.²

¹Chengdu Technological University, Chengdu, 611730, China; ²Sichuan University of Arts and Science, Dazhou, 635006, China

Objectives: To study the effect of persistent aerobic exercise and HIIT on weight loss of female students.

Methods: 72 college students were selected as the research subjects, and they were randomly divided into the control group and the observation group. 36 cases in the control group were doing the persistent aerobic exercise and 36 in the observation group using the HIIT weight loss method. The waist to hip ratio, body weight and body fat were observed and recorded in two groups.

Results: The waist–hip ratio of female students in the control group was significantly lower than that in the observation group and the difference between the two groups was statistically significant (p<0.05). The weight loss rate of female college students in the observation group was significantly higher than that in the control group and the difference between the two groups was statistically significant (p<0.05). The changes of body fat in female college students in the control group were significantly greater than those in the control group and the difference between the two groups was statistically significant (p<0.05).

Conclusions: Compared with the continuous aerobic exercise method, the HIIT weight loss method has a more significant effect on female college students’ weight loss and has a certain safety.

Research on the Influence Mechanism of Winter Swimming Exercise on the Cardiovascular System in the Middle-Aged and Elderly

Wang F., Li S.S.

School of Physical Education of Sichuan University, Chengdu, 610061, China

Objectives: To investigate the effect of winter swimming on cardiovascular function in middle-aged and elderly men.

Methods: 30 cases in the control group and 70 cases in the winter swimming group. The control group and swimming group are 60–69years of age in the elderly. The winter swimming group was followed for one year and the control group carried out index test the same year. Four items of blood lipid, electrocardiogram and cardiac function parameters were selected as index.

Results: The high density lipoprotein cholesterol of the winter swimming group was significantly higher than that of the control group (p<0.05); but there was no significant difference in low-density lipoprotein cholesterol, total cholesterol and triglyceride (p>0.05); the comparison of serum cytokines.

Conclusions: Long-term insist to winter swimming can make the heart to adapt to the morphological changes, improve cardiac function, improve myocardial blood supply and improve blood lipid metabolism, reduce the risk of AS.

Effect of Whey Protein on Aerobic Exercise Ability of Football Players

Li J.W.¹, Sun L.L.²

¹Chengdu Technological University, Chengdu, 611730, China; ²Sichuan University of Arts and Science, Dazhou, 635006, China

Objectives: To discuss the effects of whey protein on the aerobic exercise ability of football players.

Methods: A total of 36 college football players were randomly divided into control group and observation group. 18 cases in the control group were given pure water for athletes, and 18 in the observation group were given whey protein which was used as an athlete's supplementary ability. The two groups of footballers were given eight weeks of physical training and the athletes needed additional energy within one hour before and after training. The physical fitness test and blood biochemical index of the two groups of football players were observed and recorded.

Results: Compared with the control group, the erythrocyte function of the observation group was more significant, and the difference between the two groups was statistically significant (p<0.05). The results of physical fitness test in the observation group were significantly higher than those in the control group, and the difference between the two groups was statistically significant (p<0.05).

Conclusions: The application of whey protein to soccer players can strengthen the protection of erythrocyte function and has certain application value.

Research on the Role of Toll-Like Receptor 2 and Toll-Like Receptor 4 and its Signal Pathway in Pathogenesis of Primary Gout Arthritis

Cui R.J.¹, Li M.², Tuerxun G.², Li Y.³, Xie S.S.⁴

¹Sixth Affiliated Hospital of Xinjiang Medical University, Rheumatology and Immunology Department, Urumqi, China; ²Sixth Affiliated Hospital of Xinjiang Medical University, Endocrinology Department, Urumqi, China; ³Sixth Affiliated Hospital of Xinjiang Medical University, The Emergency Department, Urumqi, China; ⁴Psychological Department of College of Educational Science of Xinjiang Normal University, Urumqi, China

Objectives: To research the role of toll-like receptor 2 and toll-like receptor 4 and its signal pathway in pathogenesis of primary gout arthritis.

Methods: 72 patients with primary gout arthritis were selected as the experimental group and 72 healthy subjects were selected as control group. The real-time fluorescence quantitative polymerase chain reaction method was used for testing. The blood uric acid level, IL-1 beta level and TLR4, TLR2 were observed in two groups.

Results: Compared with the control group, the levels of uric acid, IL-1 β and TLR4 in the observation group were significantly higher than those in the control group, and there was a significant difference between the two groups (p<0.05). There was no positive correlation between plasma uric acid level, IL-1 β level and TLR2 (p>0.05). There was no correlation between TLR2 and serum uric acid level and IL-1β level in the control group (p>0.05). Conclusions

TLR4 and IL-1 beta signaling accelerating are closely related to gouty arthritis. When the TLR4 signal pathway is activated, the urine acid salt crystal changes in the patient's body.

The Study of Serum Differentially Expressed Protein in Patients with Different TCM Syndromes of Knee Osteoarthritis

Zhou Y.B.¹, Dong Z.Y.², Deng Y.J.³, Meng Q.C.⁴

¹Affiliated TCM hospital of Xinjiang Medical University, Orthopedics Department, Urumqi, China; ²Affiliated TCM hospital of Xinjiang Medical University, Surgery Department of Spine, Urumqi, China; ³Affiliated TCM hospital of Xinjiang Medical University, Surgery Department of Joint, Urumqi, China; ⁴Affiliated TCM hospital of Xinjiang Medical University, Orthopedics Department, Urumqi, China

Objectives: To study the distribution characteristics of patients with knee osteoarthritis of different TCM syndromes, and reveal the differences from the perspectives of expressions of Serum inflammatory indicators.

Methods: Selected 134 patients with knee osteoarthritis treated in our hospital from January 2013 to March 2016 and by referring to TCM syndrome types, divided these patients into three types: Y in deficiency in kidney and liver tendon and vessel stasis syndrome, spleen and kidney deficiency wet injection the osteomere syndrome, kidney Yang deficiency and weak phlegm stasis syndrome; 24 healthy persons who took physical examination in our hospital were selected as the normal control group. Collected the patients blood in the morning as the blood samples, and measured the levels of inflammatory factors (5-TH, IL-6 and TNF-α) in serum. Results

The most common TCM syndrome of knee osteoarthritis in the clinical trials is Yin deficiency in kidney and liver tendon and vessel stasis syndrome, the percents of spleen and kidney deficiency wet injection the osteomere syndrome and kidney Yang deficiency and weak phlegm stasis syndrome are near, the former is slightly higher than the latter by 3.97%. The levels of IL-6 and TNF-α in the three groups were significantly higher than those in the normal control group, while the 5-TH level was significantly lower in the three groups than in the normal control group (p<0.05).The levels of IL-6 and TNF-α in the kidney Yang deficiency and weak phlegm stasis syndrome group is significantly higher than the next two TCM syndrome groups(p<0.05),while the 5-TH level in the kidney Yang deficiency and weak phlegm stasis syndrome group is significantly lower than the next two TCM syndrome groups(p<0.05).

Conclusions: Yin deficiency in kidney and liver tendon and vessel stasis syndrome is the most common TCM syndrome of knee osteoarthritis in the clinical trials. The levels of inflammatory factors (5-TH, IL-6 and TNF-α) in serum have a close relationship with knee osteoarthritis, 3. In terms of the perspectives of expressions of serum inflammatory indicators, the most serious TCM syndrome of knee osteoarthritis is kidney Yang deficiency and weak phlegm stasis syndrome.

The Diagnostic Efficacy of Urinary VEGF in Early Stage 2 Diabetic Nephropathy

Pang L.

The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar Heilongjiang, China

Objectives: To analyze the application of vascular endothelial growth factor (VEGF) in the diagnosis of early type 2 diabetic nephropathy.

Methods: 38 patients with type 2 diabetic nephropathy diagnosed and treated from March 2016 to August 2017 were selected as the study group and the other 38 healthy subjects were selected as control group. The two groups were examined by enzyme-linked immunosorbent assay. Two groups of vascular endothelial growth factor, serum creatinine and glycosylated hemoglobin were observed and recorded.

Results: Compared with the control group, the vascular endothelial growth factor was higher in the observation group, and there was significant difference between the two groups (p<0.05). Compared with the control group, the specificity of serum creatinine and glycosylated hemoglobin was more significant in the observation group, and there was significant difference between the two groups (p<0.05).

Conclusions: The application of urinary vascular endothelial growth factor in early diagnosis of type 2 diabetic nephropathy has some clinical diagnostic value.

Effect of psychological nursing combined with rehabilitation training on ADL in patients with craniocerebral injury

Cheng R.¹, Wang R.², Xie Q.³, Qin Z.H.⁴, Wang J.X.⁵

¹Affiliated TCM Hospital of Xinjiang Medical University, The First Sectionof the Cadre Ward, Urumqi, China; ²Affiliated TCM Hospital Of Xinjiang Medical University, The Second Department of Oncology, Urumqi, China; ³Affiliated TCM Hospital of Xinjiang Medical University, Department of Gynaecology, Urumqi, China; ⁴Affiliated TCM Hospital of Xinjiang Medical University, The First Department of Cerebral Surgery, Urumqi, China; ⁵Affiliated TCM Hospital of Xinjiang Medical University, The First Sectionof the Cadre Ward, China

Objectives: To explore the effect of rehabilitation training combined with psychological nursing on the daily life ability of patients with craniocerebral injury.

Methods: 48 patients with craniocerebral injury from August 2015 to April 2017 were selected as the study subjects and they were randomly divided into control group and observation group. 24 cases in the control group were treated with routine care, and 24 cases in the observation group were treated with psychological nursing and rehabilitation training. The exercise function, daily activity ability and satisfaction degree of the two groups were analyzed.

Results: Compared with the observation group, the recovery of exercise ability was lower in the control group than in the control group, and there was significant difference between the two groups (p<0.05). Compared with the control group, the recovery of daily living activity of patients in the observation group was more remarkable, and there was significant difference between the two groups (p<0.05). The patients’ satisfaction in the control group was significantly lower than that in the observation group, and the difference between the two groups was statistically significant (p<0.05).

Conclusions: The application of rehabilitation training and psychological nursing in clinical nursing of patients with craniocerebral injury can speed up the recovery function of patients.

Effect of Early Rehabilitation Nursing Intervention on the Recovery of Cognitive Function in Patients with Craniocerebral Trauma

Qin Z.H.¹, Zhang J.J.², Wang R.³, Li H.P.⁴, Gao Y.⁵, Tan X.H.⁶, Sun Y.Q.⁷

¹Affiliated TCM Hospital of Xinjiang Medical University, The First Department of Cerebral Surgery, Urumqi, China; ²Affiliated TCM Hospital of Xinjiang Medical University, Emergency Center, Urumqi, China; ³Affiliated TCM Hospital of Xinjiang Medical University, The Second Department of Oncology, Urumqi, China; ⁴Affiliated TCM hospital of xinjiang medical university, The second department of encephalopathy, Urumqi; ⁵Affiliated TCM Hospital of Xinjiang Medical University, The Nursing Department, Urumqi, China; ⁶Affiliated TCM Hospital of Xinjiang Medical University, The Second Sectionof the Cadre Ward, Urumqi, China; ⁷Affiliated TCM Hospital of Xinjiang Medical University, The Nursing Department, Urumqi, China

Objectives: To apply the early rehabilitation nursing to the clinical nursing of patients with craniocerebral trauma and analyze the recovery of cognitive function.

Methods: A total of 38 cases of craniocerebral trauma patients admitted to our hospital were selected as the research object and they were randomly divided into observation group and control group. 19 cases in the control group were treated with routine nursing and 19 cases in the observation group adopted the early rehabilitation nursing. The recovery of cognitive function and nursing satisfaction were observed and recorded in the two groups.

Results: Compared with the control group, the effect of cognitive function recovery in patients with craniocerebral trauma was more significant. There was a significant difference in cognitive function recovery between the two groups (p<0.05). The patients’ satisfaction in the control group was significantly lower than that in the observation group, and the difference between the two groups was statistically significant (p<0.05).

Conclusions: Applying early rehabilitation nursing to the clinical nursing of patients with craniocerebral trauma can accelerate the recovery of cognitive function.

Effect of Acupuncture and Moxibustion on Serum BDNF Level, C-reactive Protein and Zinc Level in Patients with Depression

Zhi Y.¹, Wu J.X.², Guo S.J.³, Xie S.S.⁴, Zhou X.T.³

¹TCM college of Xinjiang Medical University, Urumqi, China; ²Sixth Affiliated Hospital of Xinjiang Medical University, TCM Department, Urumqi, China; ³TCM hospital of Xinjiang Yili state, Acupuncture Department, Urumqi, China; ⁴Xinjiang Normal University, Psychological Department of College of Educational Science, Urumqi, China

Objectives: To apply the acupuncture and moxibustion to the treatment of patients with depression and study the serum BDNF level, C-reactive protein and zinc level in the patients.

Methods: 35 patients with depression treated in our hospital were selected as the research subjects, and they were randomly divided into the control group and the observation group. 17 patients in the control group were treated with head massage and 18 patients in the observation group were treated with acupuncture. The levels of BDNF, C-reactive protein and zinc were measured and recorded by enzyme linked immunosorbent assay.

Results: The levels of BDNF in serum BDNF in the control group were significantly higher than those in the control group and there was a significant difference between the two groups in serum BDNF levels (p<0.05). Compared with the control group, the C-reaction protein decreased significantly in the observation group, and there was significant difference in the C-reactive protein between the two groups (p<0.05). The level of zinc in the observation group was significantly lower than that of the control group and there was a significant difference in the level of zinc in the two groups (p<0.05).

Conclusions: The treatment of acupuncture and moxibustion can effectively reduce the level of serum BDNF in patients, the level of zinc and C-reactive protein, which has a certain value of research.

Investigation on Current Status of Community Elderly Health Self-Management in Changchun

Meng W.¹, Ma X.L.², He L.L.²

¹College of Humanities of Northeast Normal University, Changchun, China; ²The second hospital of Jilin University, Changchun, China

Objectives: To investigate the current status of community elderly health self-management and its influencing factors in Changchun, and provide references for improving community elderly health status.

Methods: By using the method of random cluster sampling, choosing 480 community elderly with a questionnaire survey. The demographic data questionnaire and health self-management questionnaire were used. It includes 38 items; each item is adopted Liker l–5 grade scoring method and was scored 1–5 point according to its answer. The more the score, the higher level of health self-management.

Results: The average score was 3.95±0.73; the influencing factors were age, monthly income, whether living alone and whether having endowment insurance. The higher age, the worse status of health self-management(F=6.720, P<0.05); the higher level of monthly income, the better status (F=11.861, P<0.05); the status of community elderly who living alone was worse than not living alone (F=6.219, P<0.05); having endowment insurance's status was better than not having (F=5.474, P<0.05).

Conclusions: Current status of community elderly health self-management in Changchun was at a moderate level. Community medical workers should pay attention to community elderly with higher age, lower monthly income, living alone and not having endowment insurance, provide them with help in life, economy, medical care and so on. So as to improve current status of community elderly health self-management, and promote community elderly physical and mental health.

Investigation on Current Status of Community Elderly Health Service Demand in Changchun

Meng W.¹, Ma X.L.², He L.L.²

¹College of Humanities of Northeast Normal University, Changchun, China; ²The second hospital of Jilin University, Changchun, China

Objectives: To investigate current status of community elderly health service demand and its influencing factors in Changchun, and provide references for improving quality of community medical service and community elderly health.

Methods: Surveying 280 community elderly by using random cluster sampling method. The questionnaires include general information and Service Assessment Questionnaire. It includes nine dimensions, each item has “need” and “not need” two choice. It was scored 1 point with choosing “need”. The more the score, the higher demand degree.

Results: The average score of community elderly health service demand was 4.15±1.69, each service demand degree from high to low was: medical service (50.7%), nursing care (31.1%), familial word (28.6%), personal care (25.0%), caring hire (19.6%), home visit (14.3%), systematic assessment (10.7%), continuous monitoring (5.4%) and therapeutic training (4.3%). Its influencing factors were age, whether living alone and whether having children in the same city. The bigger age, the stronger health service demand (F=24.381, P<0.05); the demand of who living alone was stronger than not living alone (F=4.132, P<0.05); community elderly who had no children in the same city had stronger demand (F=4.813, P<0.05).

Conclusions: Community elderly health service demand in Changchun was at a moderate level. Community medical persons should provide more medical service and nursing care, keep a watchful eye on community elderly with bigger age, living alone and have no children in the same city, then improve community elderly health.

Multi-Template Molecularly Imprinted Solid Phase Microextraction Coatings for Different Kinds of Environmental Pollutants Analysis

Zhao D.D., Xu Z.G.

Faculty of Science, Kunming University of Science and Technology, Kunming, China

Objectives: Molecularly imprinted solid phase microextraction (MIP-SPME) techniques have been rapidly developed in sample preparation and environment analysis. Multi-template molecularly imprinted solid phase microextraction coatings were prepared and used for different kinds of environmental pollutants analysis.

Methods: Ethyl 4-hydroxybenzoate (EP), bisphenol A (BPA) and dibutyl phthalate (DBP) were chosen as the templates in this study. Different kinds of MIP-SPME coatings were prepared, including single-template MIP-SPME coatings, dual-template MIP-SPME coatings, and three-template MIP-SPME coatings. The extraction performances of the MIP-SPME coatings were deeply investigated.

Results: Under the optimum conditions, the double-template MIP-SPME coatings by using EP and DBP as the templates showed the best extraction performance. The imprinting factors for three template molecules were 1.35, 1.44 and 1.43, respectively. The dual-template MIP-SPME coatings were further characterized by scanning electron microscopy. The hom*ogeneous and porous surface structure was beneficial for target analytes adsorption and mass transfer.

Conclusions: A novel strategy to detect different environmental pollutants by using multi-template molecularly imprinted solid phase microextraction coatings was proposed. The MIP-SPME coatings were successfully used for different kinds of environmental pollutants analysis in real river water samples.

Acknowledgements: Supported by a project grant from the National Natural Science Foundation of China (Grand No. 21565018).

A Study on the Psychology Violence against Married Women in Rural areas of Tangshan

Xue L., Wu J.H., Liu N., Cui L.H., Guan Y., Li Z.Y., Zhao C.X., Pang S.L., Lou H.R., Sun L., Wang M.

School of Public Health & Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, North China University of Science and Technology, Tangshan 063210, Hebei, China

Objectives: To study the status of psychology violence in rural areas of Tangshan and reveal the influence factors affected the domestic violence.

Methods: A face to face investigation was carried out with married women in 3 villages of Tangshan. SPSS24.0 software was applied to analysis data. Chi square test and non conditional logistic regression model were used for the status and influencing factors of women's psychology violence were analyzed.

Results: The prevalence rate of psychology violence against women was 49.7%. The main reasons leadings to psychology violence included women's labor type, women's views on gender roles, violence experience of her mother and fear of her husband.

Conclusions: A study on the psychology violence was proposed against married women in rural areas of Tangshan. Rural women are more likely to suffer from psychology violence, especially psychology violence. More than 20% women often suffer from violence, which will have a great impact on women's physical and mental health.

The Differential Diagnosis Between Aplastic Anemia and Hypocellular Myelodysplastic Syndrome

Wu J.H.¹, Xue L.¹, Lv Y.F.¹, Gao H.¹, Wang K.K.¹, Song J.², Yin S.F.¹, Zhou Y.¹, Zhang X.Y.¹, Cao Y.Z.¹, Wang Q.¹, Yuan X.¹, Song Y.¹, Wang G.L.¹

¹School of Public Health & Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, North China University of Science and Technology, Tangshan 063210, Hebei, China; ²Department of Hematology, North China University of Science and Technology Affiliated Hospital, Tangshan 063210, Hebei, China

Objectives: This research was aimed to explore the combined examination value of hemogram, blood smear, bone marrow smear, flow cytometry and blood progenitor cells test in AA and hypo-MDS differential diagnosis.

Methods: 209 cases of AA and 122 cases of hypo-MDS patients were collected from Blood diseases hospital, Chinese academy of medical sciences and then we analyzed the differences of two groups in each check.

Results: Bone marrow flow cytometry tests showed that mature lymphocytes percentage in hypo-MDS group was significantly lower than that in AA group (p<0.001), but primitive cells, granulocyte, mature mononuclear cells and immature red blood cells were significantly higher than AA group (p<0.001). Flow cytometry examination results in peripheral blood showed that hypo-MDS group CD3-CD16/CD56⁺ NK cells proportion was significantly higher than that in AA group (p<0.05), CD3⁺CD57⁺T-LGL cells (large particles T lymphocytes) ratio was also significantly higher than that in AA group (p<0.001). Blood progenitor cell culture experiments showed that the number of colony forming unit-erythroid (CFU-E) in hypo-MDS group was significantly higher than that in AA group (p<0.01), and burst forming unit-erythroid (BFU-E) and colony forming units-granulocyte macrophage (CFU-GM) were also higher than AA group (p<0.001).

Conclusions: It was very important that combined the examination of hemogram, blood smear, bone marrow smear, flow cytometry and blood progenitor cells test in AA and hypo-MDS differential diagnosis.

Acknowledgements: We gratefully acknowledge Chen Naiyao, Department of Hematology, North China University of Science and Technology Affiliated Hospital, for contact the survey site. We thank Yan Zhenyu, Department of Hematology, North China University of Science and Technology Affiliated Hospital, for guiding disease identification.

A Study on Mental Health Assisted Diagnosis Based on Machine Learning and Image Cognition

Zhao J., Wu C.M., Deng F., Li H.B., Jia J., Zhang S.L.

School of Information Science and Technology, Northwest University, Xi'an, China, 710069

Objectives: This paper provides an effective method for assessing mental health. The method can quickly obtain and quantify the respondents’ information and provide a supplementary reference for subsequent diagnosis.

Methods: In cognitive psychology, the psychological disorder patients differ from normal people in the negative emotions of the attention bias, this design based on image recognition and behavioral response of the image psychology test system. The system can obtain quantitative data, such as the use of positive and negative attributes after the emotional image to stimulate the keyboard response time, and use the machine to analyze and assess the mental state of the subject.

Results: The experimental results show that the correct rate of this kind of image psychology test system is 84.3%, which is helpful to the diagnosis of mental health.

Conclusion: Traditional mental health diagnosis is largely limited by the experience of the psychiatrist and the subjective will of the interviewee. The psychological test system proposed in this paper can quickly obtain and quantify the respondents’ information, which proves that the application of artificial intelligence to cognitive science is helpful to the diagnosis of mental health.

Acknowledgment: This work was supported by National Natural Science Foundation of China(No. 61379010,61772421).

Effect of Total Glycosides of Bulbus Allii Macrostemi on Reserpine Induced Depression Model Mice

Kang L., Miao M.S.

Henan University of traditional Chinese medicine, Zhengzhou, China

Objective: To observe the effect of total glycosides of bulbus allii macrostemi on reserpine induced depression model mice.

Methods: Mice model of depression induced by intraperitoneal injection of reserpine. Give Fluoxetine Hydrochloride Tablets every day (10mg/kg), and large, medium, small dose of total glycosides of bulbus allii macrostemi (300mg/kg, 150mg/kg, 75mg/kg), and the blank group and the model group were given the same volume of distilled water at the same time, 1 times a day, continuous 7days. After the last administration of 1H, intraperitoneal injection of reserpine (4mg/kg) was performed, and then the degree of eyelid ptosis was observed and the body temperature was measured after 4h.

Results: Reserpine induced depression model in mice was successfully replicated. Total glycosides of bulbus allii macrostemi can significantly or clearly reduce the mice eyelid ptosis score, and significantly improvement in body temperature decline.

Conclusion: Total glycosides of bulbus allii macrostemi of each dose group can significantly reversed reserpine mice out of the circle rate decreased, and the mice ptosis degree, improve the reserpine induced depression model mice decreased body temperature, and the extent of eyelid ptosis in mice. It also improved the hypothermia in reserpine induced depression mice.

Keywords: Total glycosides of bulbus allii macrostemi; Depression; Animal model.

Research on the Cracks Extending Mechanism of Grinding Silicon Nitride Ceramics under Green Manufacturing

Wu Y.H.^1,2, Sun J.¹, Zhang K.¹, Wang H.^1,2, Zhou P.³

¹School of Mechanical Engineering, Shenyang Jianzhu University, Shenyang, China; ²State and Local Engineering Laboratory, Shenyang Jianzhu University, Shenyang, China; ³Technology Department, Shenyang Jianzhu University, Shenyang, China

Objectives: Because of the hard and brittle properties, there is often a surface damage such as cracks on the silicon nitride ceramics at the grinding process under diamond wheels. In order to improve processing quality and reduce waste of materials the following has been studied.

Methods: The crack depth model of grinding surface on ceramics is established based on indentation fracture mechanics in this paper and the extending process of the crack is simulated by Two-Dimensional discrete element simulation of UDEC. The plane grinding experiment of silicon nitride ceramics by diamond wheel is carried out and the extending of its cracks is observed on the surface.

Results: Cracks appear on the surface of the ceramics under the action of single diamond grain, the lead crack extends along the interior of the ceramic in the form of longitudinal cracks. The failure zone consists of tensile failure element and shear failure element, and the shear failure is main failure form. At grinding process, the crack extends along the arc and wheel direction of rotation in the contact area between the wheel and the ceramic. When the penetration depth increases, the crack form is gradually transformed from the tensile failure element to the shear failure element. The number of broken parts in the cut is obviously more than that of the cutting part.

Conclusions: Grinding damage of engineering ceramics could be forecasted and controlled by this simulation. The grinding process could be optimized and grinding efficiency and quality could be improved.

Acknowledgments: The authors acknowledge the collective support granted by National Natural Science Foundation of China (Grant No 51375317), Innovation Team Project of Ministry of Education of China (Grant No IRT_15R45), Housing and Urban-Rural Development Program of China (Grant No 2015-K3-006), Science Research Project of Shenyang Jianzhu University (Grant No 2017015) and Open Foundation of Key Laboratory (Grant No SJSC-2016-5).

Design and Application of Portable Micro Sleep Apnea Alert System

Wang Y.N.¹, Guo Y.H.²

¹School of Electrical and Electronic Engineering, North China Electric Power University, Baoding, China; ²Baoding First Central Hospital, Baoding, China

Objectives: Obstructive sleep apnea syndrome is mostly diagnosed by respiratory diagnostic instruments. But these instruments are expensive and complicated; they are not suitable for real-time observation in patients’ homes. In daily life, a sudden onset in sleep is often overlooked. To solve this problem, this paper provides a portable micro sleep apnea alert system.

Methods: The system includes monitor, mobile phone and alert wristband. The monitor includes a multi-sensor acquisition module, a data processing module and a wireless transmission module. The collected data is sent to the mobile phone, the mobile phone analysis software records data and evaluates the quality of sleep. When the monitoring value exceeds the alarm threshold, the mobile phone will send the message through the wireless network to the family members wearing the alert wristband, so that the patient will be treated in time.

Results: The experiment of the system's stability and accuracy is done, which exhibits good performance, it can provide convenience for home monitoring.

Conclusions: The system has the advantages of low cost, convenient wearing and high monitoring accuracy.

Acknowledgements: Supported by the Fundamental Research Funds for the Central Universities (No. 2015MS99).

The Current Situation of Community Elderly Sexual Psychology Research

Sun W.J., Liu Y.J.

Nursing Department, Welfare College, College of Humanities, Northeast Normal University, Changchun, Jilin, China, 130117

Population aging causes more and more health problems of the elderly. Generally considered that people to the old age, loss of fertility, there is no need for sexual activity. In fact, most healthy elderly people can correctly treat sexual problems caused by aging of the body, and there are normal sexual activity, but there are some elderly people with sexual problems and psychological barriers. The elderly sexual offenses, sexually transmitted diseases, sexual health issues gradually increased. Sexual psychological problems not only in adolescents, the elderly sexual psychological problem has been widespread concern in society. Therefore, the community elderly should be aware of the elderly sexual function and sexual psychology. Establish a correct sexual concept, to treat sexual activity as a normal physiological need for good health, to overcome the psychological misunderstanding. So that the community elderly has a healthy and harmonious elderly sexual life, to improve the quality of life of the elderly community is of great significance.

Keywords: elderly; sexual psychological.

Acknowledgements: Supported by a project grant from Social Science Fund of Jilin Province (2017A8).

The Application and Exploration of Gerontological Nursing Practice Courses on Nursing Undergraduate Students

Sun W.J., Zhao X.F.

Nursing Department, Welfare College, College of Humanities, Northeast Normal University, Changchun, Jilin, China, 130117

Objectives: To analyze the effect of gerontological nursing practice courses on nursing undergraduate.

Methods: Gerontological nursing practice courses were designed, the course was included Japanese nursing technology basic knowledge, well-being philosophy and Taiwan nursing care idea, the time of gerontological nursing practice were increased situational teaching method were used in practical classes, and organized the student as volunteers to visit elderly home and nursing house. Elderly Attitude Scale was used to analyze the students’ attitude toward older nursing.

Results: Compared with before learning,84.1% students is at good level, the elderly scores higher than before learning (p<0.05), the radio was improved from 78.41% to 92.05% in students’ interest of gerontological nursing learning, the radio of willingness for caring the elderly was increased from 71.59% to 88.64% (p<0.05).

Conclusions: The gerontological nursing practice course can effectively enhance the nursing students’ interest in gerontological learning, improve students attitudes toward the elderly, to improve students’ willingness to care for the elderly.

Keywords: education, nursing; elderly nursing; curriculum construction practice.

Acknowledgments: Supported by a project grant from Higher Education Department social science research of Jilin Province 2016(499).

Web Comment Mining of Online Course in the View of Data-Driven Education

Yang F.¹, Wu Z.²

¹College of Computer, Hubei University of Education, Wuhan, China; ²Physical Education School, Wuhan Business University, Wuhan, China

Objectives: The main aim of this paper is to promote an evaluating method to improve the teaching effect by crawling web comments of online-course, segmenting Chinese words and some mining models.

Methods: The paper promotes a new dynamic evaluation model and a case of positive analysis. Firstly, we use crawler technology to get lots of web comments of online-course and preprocess them; the second is the word split algorithm and the short text clustering; finally, the co-word analysis and clustering is used to construct a common words graph. And then, a text emotion mining algorithm is promoted by the common words graph and the ordered words graph. In this, web comments are quantified reasonably to become an index of the dynamic evaluation model.

Results: Results show that the methods of short text mining are suitable for web comments of online course. And the case analysis of online-course shows that the result from the evaluation model calculation matches the practice better.

Conclusions: Comments are changed into scores represented the learner's emotion. It can be used to analyze the heavy and difficult of online-course knowledge on the learner's point of view. And the new dynamic evaluation model can be implemented to improve the teaching effect.

Acknowledgements: Supported by Hubei province scientific research projects funded projects(No. Q20173004)and Supported by the Humanity and Social Science Youth foundation of Ministry of Education of China (No. 14YJCZH165).

Ecological Design Practice Study of Chengdu Urban Scenic Spots for the PM2.5 Air Pollution Problem

Zhou R.¹, Zhou M.¹, Fei L.F.², Huang C.³, Bi J.⁴

¹College of Fine Art and Design, Xihua University, Chengdu, China; ²Department of digital art, Chengdu Neusoft University, Chengdu, China; ³Chengdu Environmental Monitoring Center Station, Chengdu, China; ⁴College of Applied Technique, Xihua University, Chengdu, China

Objectives: In order to promote the construction of “world tourism destination” in China, contingency measures and strategies for the air pollution problems such as PM2.5, which is highly concerned by the public, should be plan in urban scenic spots.

Methods: Through the questionnaire survey on the attitude of Chengdu tourists on the haze and the influence of their behavior decisions at existing scenic spots, this paper proposes the concept of air purifying tree according to the environmental characteristics of urban scenic. LED anion purification technology has application in the ecological design to deal with air pollution problem, especially PM2.5. And the air pollutants in urban scenic spots such as benzene and toluene were detected by GC-MS with summa canister, fine particulate by PM2.5 detector.

Results: By means of environmental monitoring and experimental comparison, the air purifying tree which with LED anion purification technology can reduce the air pollution of PM2.5 in small-scale space. The testing laboratory found that the removal rate of PM2.5 by the air purifying tree can reach 9.9% in 12h.

Conclusions: The air purifying tree provides beneficial and feasible ideas for urban scenic to establish ecological emergency strategies, and to improve the tourism ecological facilities through ecological design. The combination of industrial design and LED anion purification technology is applicable for urban scenic spots to relieve PM2.5 air pollution problem stress.

Acknowledgements: Supported by a project grant from General project of Sichuan Province Cyclic Economy Research Center (Grant No. XHJJ-1712); Philosophy and Social Sciences Planning Project of Chengdu (Grant No. 2017P28); General project of Sichuan Province Tourism Development Research Center (Grant No. LXC17-12); Project of Sichuan Landscape and Recreation Center (Grant No. JGYQ2017034).

Extract Medical Interpretation Based on UMLS Semantic Network

Ding C.C., Zhong B.R., Qin D.

School of Computer Science, Yangtze University, Jingzhou 434023, China

Objectives: Knowledge extraction gives the potential for producing high quality representation of the file and could help storing, retrieving, sharing, and management of explicit biomedical knowledge. This paper addresses the task of mining binary relationships between concepts from biomedical document for scientific discovery from medical document.

Methods: We first created several relation templates with the help of UMLS semantic network, which has defined the domain entities and the internal relation network between them. The related indictor words are defined as syntactic constraints beforehand. The subject and object relevant to the given indicator words are identified from medical sentences to match the arguments in relation templates. When all constraints satisfied, the binary relation between the medical concepts is extracted into a structured form.

Results: Medical concepts with the similar role are grouped as a union to improve the recall and decrease the futile calculate. The medical relations are extracted according the syntactic and semantic mapping. Experiment show that the biomedical extraction system which proposal get better performance.

Conclusions: We introduce a concept union which is a group of concepts act the same or similar role in the sentence. This will improve the recall of the knowledge extraction and decrease the time for less union involved. In the future, more experiments are required to do further analysis of the rules underlying in the biomedical extraction.

Acknowledgements: This paper was supported by the Natural Science Foundation of Hubei Province of China (NO. 2015CKB740).

Relationship and Practice of Drug Property and Efficacy

Miao M.S., Tian S., Kang L., Li M.Y., Bai M., Lou X.

Henan University of Chinese Medicine, Zhengzhou, China

Objectives: This paper analyzed the relationship between traditional Chinese medicine (TCM) property and modern medical effect, and clarified the relationship between the four properties, five flavors, raising, lowering, floating and sinking, channel tropism, toxicity of herbs and the modern medical effect.

Methods: Through literature retrieval to collected the related information, we comprehensive combed the relationship between the properties and effect of TCM medicine. Based on the characteristics of clinical disease, according to the principle of “diagnosis and prescription”, to clarified the relationship between the properties and effect. And it will help us to reveal the potential pharmacological activity and the application prospect of TCM.

Results: The property and functions of TCM were closely associated with the modern pharmacological activities, such as four properties, five flavors, clearing away heat and toxic materials, activating blood to resolve stasis, nourishing kidney and so on. The effect of TCM is a reflection of the modern pharmacological activities, such as the drug which is cold more has the pharmacological effects of anti-infection and tumor, the drug which is bitter more has the effect of insecticidal, antibacterial, anti-inflammatory, diarrhea, and so on. In addition, the drug belong to the Liver Channel that has the anticonvulsant effect, the heat-clearing drug more has the effect of resistant to the original microbes, anti-inflammatory, antipyretic; The blood-activating and stasis-resolving drug has the effect of improve microcirculation, improve hemodynamics, resistance to ischemic tissue damage, abnormal tissue proliferation inhibition. Through the explore of the relationship of drug property and efficacy, we set up the corresponding database system of the TCM property and flavor in the modern research, the function of TCM - pharmacology - the clinical database system, through the database of digging, clarify the efficacy of TCM potential activity, and carry out the corresponding pharmacodynamics research, and found the new applications of TCM, provide the new ideas for the development of new TCM and the medicinal materials substitutes.

Conclusion: Through the literature retrieval, data analysis, we had found that it has a connection between the TCM property and the modern medical effect, and through the establishment of corresponding database, it will promote the modern development of TCM, and provide the basis for the comprehensive application of TCM.

Acknowledgements: Supported by a project grant from National “major new drug creation” major science and technology projects (Grand No. 2017 zx09301071), Henan province outstanding scientific and technological innovation team (Grand No. TCJ2014-391).

The Status and Influencing Factors of Psychotropic Drug in the Elder in China

Liu Y.J.¹, Zhang M.², Sun W.J.¹

¹Nursing Department, Welfare College, College of Humanities, Northeast Normal University, Changchun, Jilin, China, 130117; ²School of Nursing, Beihua University, Jilin, Jilin, China, 132000

Objectives: To analyze the current situation and influencing factors of psychotropic drug use in elder in China.

Methods: 337 patients of sleep disorders, chronic pain, anxiety and mood disorders hospitalized elderly patients (aged 60 or higher) were studied, the application of the drug investigation questionnaire and the old rational use drug investigation questionnaire were used to survey the drug use habits, medication frequency, how to get drugs, SPSS17.0 was used to do statistical analysis of data.

Results: 85.75% elder patients were equipped with psychiatric drugs, 91.09% of the elders were with common painkillers, and the elder take 2–3 drugs of the same function every day. Older people often take psychotropic drugs by their own experience. Most older people don't understand the side effects of drugs. 75.6% elder thought that they could take the medicine without the doctor's advice. The degree of education has more influence on drug use.

Conclusions: It is unreasonable in the psychotropic drugs use in elder patients; there are many phenomena such as multi-purpose, indiscriminate using and discontinuation of drugs.

Keywords: psychotropic drugs; the elder; rational use; drug use.

Acknowledgements: Supported by a project grant from the Social Science Funding Department of Jilin Province (2017A8 and 2016B169).

Smart Wearable System for Personal Occupational Health and Safety in Severe Electric Power Working Environment

Chang Z.W.¹, Xie X.N.², Chen Y.¹, Peng Q.¹

¹Sate Grid Sichuan Electric Power Research Institute, Chengdu 610072, China; ²Chengdu University of Information Technology, Chengdu 610025, China

Aims: In the severe environment such as high altitude localities and depopulated zones, it is a big challenge to ensure the personal health and safety of electric power on-site workers. Based on wearable devices, we can realize health monitoring, abnormal alarm, communication positioning and on-site intelligent safety control.

Methods: Firstly, through pathological analysis of blood oxygen, heart rate, ECG three physiological signals, the key indicators of human health are designed for Sichuan plateau and other harsh environment. Then, the communication gateway with near-field communication, data transmission, environmental monitoring, identification and other functions are developed, as wearable armbands or epaulettes easy to use on-site. Health status assessment, environmental status warning and visual operation management are realized the combined with electric power project plan, team work division, environment and positioning data. Moreover, the system meets the requirements of power grid information security of mobile terminals, such as the physical isolation of Intranet and Internet, the mobile terminal software of server, gateway, mobile phone and so on.

Results: A smart wearable system is developed for electric power working site. The proposed system includes a smart ECG monitoring watch, and a wearable environmental atmosphere monitoring communication gateway. The health of on-site workers and the working environment are monitored and warned. The visual management of operation plan and division of personnel is realized based on communication of wearables, visual terminals and servers.

Conclusions: Based on the Internet of things and wearable technology, the proposed system is applied successfully in Sate Grid Sichuan Electric Power Research Institute, especially for the projects of plateau area. The occupational health safety and enterprise safety production are guaranteed using the wearable system.

Acknowledgements: Supported by Key R&D Projects of Sichuan Province(No. 2017GZ0068), and a project of State Grid Sichuan Electric Power Corporation.

Separation and analysis of ascorbic acid racemates in drugs

Liu Y.J., Wang D., Xu Z.G.

Faculty of Science, Kunming University of Science and Technology, Kunming, 650500, China

Objectives: A reverse phase liquid chromatography method was proposed to separate and analyze ascorbic acid racemates in drugs by using a hydrophilic interaction liquid chromatographic (HILIC) column.

Methods: The chromatographic column was Venusil Hilic (5μm, 150×4.6mm, Agela Technologies). All the chromatographic conditions had been optimized. The mobile phase was acetonitrile-0.1% phosphoric acid solution (93:7, V/V). The flow rate was 0.6mL/min. The column temperature was 20°C and the detection wavelength was 243nm.

Results: The ascorbic acid racemates were baseline separated. The resolution (Rs) was 7.79. Three ascorbic acid drugs were separated and analyzed by the proposed method. Only (L)-ascorbic acid was found in three real samples. The contents of (L)-ascorbic acid in three drugs were 96.62mg/g and 985.8mg/g, respectively.

Conclusions: The proposed HILIC method was high efficient for ascorbic acid racemates chiral separation. It could be used for ascorbic acid racemates detection in real drug samples.

Acknowledgements: Supported by the National Natural Science Foundation of China from the Grand No. 21565018.

Molecularly Imprinted Monolithic Bar Microextraction Coupled HPLC for Environmental Estrogens Analysis in River Water Samples

Zhao D.D., Zheng W.Q., Xu Z.G.

Faculty of Science, Kunming University of Science and Technology, Kunming, 650500, China

Objectives: Bisphenol A (BPA) was used as template to prepare molecularly imprinted monolithic bar. Monolithic bar microextraction coupled with HPLC was then employed to analyze bisphenol estrogens and steroid estrogens simultaneously.

Methods: Monolithic bar microextraction was performed at a shaking frequency of 150rpm. The extraction time and desorption time were 90min and 15min, respectively. And 20μL of the desorption liquid was used for chromatographic analysis. All the analytes were detected at the wavelength of 230nm.

Results: The molecularly imprinted monolithic bar showed good selectivity to six kinds of bisphenol estrogen and steroid estrogen compounds. The highest imprinting factor was 1.5. The linear ranges were from 1.0μg/L to 100μg/L for six environmental estrogens. The limit of detection for six estrogen compounds ranged from 0.37 to 0.73μg/L. The recovery of six kinds of environmental estrogens in spiked river water samples ranged from 70.5% to 109.3%.

Conclusions: The proposed method of molecularly imprinted monolithic bar coupled with HPLC was high efficient for bisphenol estrogens and steroid estrogens analysis simultaneously in real river water samples.

Acknowledgements: Supported by the National Natural Science Foundation of China from the Grand No. 21565018.

Metal Organic Frameworks Solid Phase Extraction Coupled HPLC for Phenolic Pollutants Analysis in River Water Samples

Yang Y.M., Xu Z.G.

Faculty of Science, Kunming University of Science and Technology, Kunming, 650500, China

Objectives: Three metal organic frameworks (MOFs) were prepared and used as solid phase extraction (SPE) adsorbents to analyze phenolic pollutants in river water.

Methods: Three MOFs (Cu(4-C5H4N-COO)2(H2O)4, Co(4-C5H4N-COO)2(H2O)4 and MOF-5) were prepared. 0.050g MOF was used as adsorbent for SPE each time. All the extraction conditions were optimized. All the analytes were detected at the wavelength of 280nm.

Results: Best extraction performance could be obtained by using [Cu(4-C5H4N-COO)2(H2O)4] as adsorbent. And 20.8μg/L triclosan could be detected in real river water samples. The recovery of three phenolic pollutants in spiked river water samples ranged from 81.80% to 106.51%. The relative standard deviation was 6.9% to 13%.

Conclusions: The proposed method of MOFs-SPE coupled with HPLC was efficient for phenolic pollutants in real river water samples. MOFs would be an potential adsorbents in sample preparation field.

Acknowledgements: Supported by the National Natural Science Foundation of China from the Grand No. 21565018.

Clinical Application Study on the of Interventional Therapy of Cerebrovascular Disease Based on the Fuzzy Fusion

Yan Y.^1,2, Zhang C.³, Jia K.K.^1,2, Wang Y.W.^1,2, Cai J.L.^1,2, Liang J.X.^1,2, Yang A.M.^1,2

¹Hebei Key Laboratory of Data Science and Applications, North China University of Science and Technology, Tangshan, China; ²Engineering Computing and Simulation Innovation Laboratory, North China University of Science and Technology, Tangshan, China; ³School of Computer Science and Technology, Harbin Institute of Technology at Weihai, Weihai, China

Objectives: Cerebrovascular disease poses a great threat to human health, so interventional therapy of cerebrovascular disease is considered to be an effective medical treatment for cerebrovascular disease.

Methods: This paper explores the data fusion process of force feedback system in interventional therapy of cerebrovascular disease.

Results: Through the simulation experiment, the degree of improvement of interventional therapy is compared and analyzed, and the real-time performance and effectiveness of fuzzy fusion are discussed. It plays an active role in reducing the risk of interventional treatment of cerebellar vascular diseases and guiding the interventional treatment of cerebrovascular diseases.

Conclusions: In this paper, through the establishment of fuzzy fusion model, on the one hand, the two sensor measurement signals are quantized into fuzzy collision state, With reference to certain rules, different sensor data will be merged into a unified state. It can realize the fuzzy fusion of different data in force feedback loop and solve the problem of signal oscillation in the process of cerebral vascular interventional treatment. On the other hand, the improved fuzzy algorithm improves the performance of data processing in the vascular interventional system.

Acknowledgements: Supported by a project grant from National Natural Science Foundation of China (Grand No. 51674121) and National Natural Science Foundation of Hebei Province (Grand No. E2017209178) and Science and Technology Project of Hebei Province (Grand No. 15214104D) and National Natural Science Foundation of Hebei Education Department (Grand No. QN2016088).

Research on the Generation Mechanism of the Behaviors of Entrepreneurial Decision Maker

Li L.F.¹, Chen Q.S.², Wu G.Q.², Liu Z.X.³

¹The Institute of MBMT&SD, Sichuan University, Chengdu 610064, P.R. China; ²Department of Management Science, Sichuan University, Chengdu 610064, P.R. China; ³West China Hospital, Sichuan University, Chengdu 610041, P.R. China

Objectives: The Behaviors of Entrepreneurial Decision Maker are critically important to the development of a startup company. Some of these behaviors may lead a new start-up to rapid development, or on the contrary, bankruptcy. Thus, there are great theoretical and practical values to explore the generation mechanism of the Behaviors of Entrepreneurial Decision Maker for improving the success rate and outcomes of entrepreneurship.

Methods: Based on the Theory of Planned Behavior and the Social Cognitive Theory, the theoretical analysis framework for the Behaviors of Entrepreneurial Decision Maker was constructed and the Behavior Model of Entrepreneurial Decision Maker was established. A total of 6 variables were designed, including the behavioral highlight belief, the behavioral attitude, the subjective norms, the perceived behavioral control, the behavioral intention and the behaviors of entrepreneurial decision maker. Data of 320 entrepreneurs were collected through the corresponding questionnaire survey. Then, the scientificity and rationality of the established model was validated by the statistical analysis method and the indirect influence and direct influence of the key variable to the Behaviors of Entrepreneurial Decision Maker were explored.

Results: The results suggest that the personal and environmental factors of entrepreneurial decision maker can directly affect their behavioral beliefs, and in turn, indirectly affect their behavioral attitude, subjective norms and perceived behavioral control. Ultimately, the behavioral intention of the entrepreneurial decision maker will be influenced, which directly determines the actual behaviors of entrepreneurial decision maker. Meanwhile, the Behaviors of Entrepreneurial Decision Maker also counteract against the behavioral belief, the behavioral attitude and the perceived behavioral control of entrepreneurial decision maker.

Conclusions: In order to improve the effect of the Behaviors of Entrepreneurial Decision Maker and reduce the decision-making errors, entrepreneurs must improve their entrepreneurial spirit and entrepreneurial capability. At the same time, the government and society should create a friendly external environment to help entrepreneurs avoid invalid decision-making behaviors.

Acknowledgements: Supported by the national social science foundation of China, No. 16BGL024.

Study on Journal-cover Design of International Medical Science Scholarly Journals Based on Eye-tracking Technology Testing on the Background of New Media Communication Age

Wu H.¹, Zhang Y.Q.¹, Gao X.S.¹, Luo B.F.¹, Fei L.F.²

¹College of Fine Art and Design, Xihua University, Chengdu, China; ²Department of digital art, Chengdu Neusoft University, Chengdu, China

Objective: In this era the trend of new media dissemination urges that medical academic journals need Internet thinking to develop their digital publication, focusing on what is hot and their tracks to explore the world-class case analyses of cover design so that g their development can be strictly followed.

Methods: THE LANCET, The BMJ, and Genes to Cells are chosen as the target medical journals for test. Six scholars were selected for eye tracker test experiment, aiming at user attention to journals cover mapping. At the same time the Economist, Science and other non-medical international journals are also chosen for case analysis in order that current international academic journals cover design trends are closely followed.

Results: Eye tracker test results show the top spotlight on titles and cover articles for academic medical journals are the most eye-catching, with the edges of the cover earning enough attention as well. As can be seen from the case studies, the current top international academic journals attach more importance to the visualization of the current theme information of the cover image. In other words, the trend of visibility of the information is always focused.

Conclusions: Academic medical journals should attach importance to the visualization of the academic content of the cover, making it easier for readers to learn more about the academic achievements of journals, thus achieving better result of dissemination. It is hoped that through the cover design and making the cover more suitable for hand-held reading habit via electronic devices, cover design can be better adaptable to APP's icon design to promote academic journals to be more in line with the needs of new media.

Analysis of the Need for Legislation of Chinese Basic Medical Services

He G.Z.¹, He G.R.²

¹School of Public Health, Kunming Medical University, Kunming, China; ²Shanghai Invision Digital Technology Inc., Shanghai, China

Objectives: This paper proposes suggestions to legislate and clearly define what should be provided by the basic medical services, to strengthen the government's financial guarantees, regulate basic medical service prices, and assure citizens’ basic right to medical services. Such legislation would fully guarantee citizens’ basic right to medical services and mobilize social medical resources, and improve the quality of basic medical services.

Methods: This paper adopts a cross-sectional analysis upon health-care legislation in developed countries as compared with that in china, hails the urgency and necessity of Chinese basic medical services legislation, and proposes suggestions thereof.

Results: Improvement in quality and the expansion of basic medical services requires that high-level authorities provide consistent explanations of the coverage provided by the basic medical services; a uniform medical services act is needed to eliminate the imbalance in the development of basic medical services; and a unified basic medical service act is needed to ensure that all patients pay the same for the same treatments.

Conclusions: The exiting medical service normative documents in China are insufficient to fully guarantee citizens’ right basic medical services. It is imperative to formulate basic medical laws consistent with the national level of economic and social development.

Acknowledgements: Supported by the project grant from the National Natural Science Foundation of China (NSFC, Grant No. 71363001).

Component Analysis of Polyphenol from Mango Kernel Seeds and its Antioxidant and Antibacterial Activity

Kang C.^1,2, Luo Y.H.^1,2, Duan Z.H.^1,2

¹Research Institute of Food Science & Engineering Technology, Hezhou University, Hezhou, China; ²Food and bioengineering college, Hezhou University, Hezhou, China

Objectives: Mango kernels are rich sources of polyphenols with different health-promoting properties. Our aim was to analyze the component of polyphenol from mango kernel seeds and evaluate its functional properties.

Methods: Polyphenols of mango kernel seeds (Yu Mango) were extracted by ethanol, and then separated by silica gel column chromatography, thin layer chromatography. The structure of the purified compound products were analyzed by infrared spectrum and nuclear magnetic resonance. The free radical scavenging activity was determined by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals(OH^-)assay. Antibacterial activity was evaluated by disc diffusion assay with three medically important bacterial pathogens such as methicillin resistant Staphylococcus aureus (S. aureus) (MRSA), Vibrio vulnificus (V.vulnificus) and Escherichia coli (E.coli).

Results: The main component purified by 30% or 50% ethanol was gallic acid, while 70% ethanol and 90% ethanol were ellagic acid and castor oil acid, respectively. The free radical scavenging study indicated the purified polyphenols gallic acid had higher activity than ellagic acid and castor oil acid (p<0.05). The purified polyphenols extract of mango seed kernel at a concentration of 100mg/mL is found to have potential antimicrobial activity against MRSA and E.coli compared to V.vulnificus.

Conclusions: The experimental result confirms that the purified polyphenols from mango kernel seeds had strong antioxidant and antibacterial activity, which would provide an important basis for comprehensive utilization of mango kernel.

Acknowledgements: Supported by a project grant from Guangxi young and middle-aged teachers ability promotion project (2017KY0656), Special Fund for Distinguished Experts in Guangxi ([2016]21) and Doctoral foundation project (HZUBS201515).

Research on Remote Medical Monitoring System Based on Android

He Y.Q.¹, Duan D.J.²

¹Henan Institute of Engineering, Zhengzhou, China; ²The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Objectives: In order to improve convenient and flexible communication between doctors and patients, and provide a full range and seamless, medical interaction monitoring services for patients. At the same time, improve the medical efficiency from treatment to prevention and the quality of life of patients.

Methods: This paper designs a remote medical monitoring system based on Android, which is portable, wearable, interactive, small volume, high precision and convenient operation, it adopts the idea of modular design, designed the physiological parameters acquisition module, the android-based monitoring module, and the remote monitoring center. The physiological parameters acquisition module has the function of collecting user's ECG, heart rate, pulse, blood oxygen saturation, body temperature and other physiological parameters. the android-based monitoring module has the function of user login, modify the basic information and physiological parameter display, through Bluetooth adapter receive the data transmits from physiological parameter acquisition module, after data processing, storage and display, transmits the data to the remote monitoring center through GPRS wireless communication technology.

Results: Through the multiple tests on the system, the results show that the monitoring system with high stability and achieved accurate measurements of physiological parameters, to meet the design requirements of system.

Conclusions: The system can realize the real-time monitoring of human body physiological parameters, so that doctors and patients can understand the physical health status of the patients at any time.

Acknowledgements: Supported by a project grant from science and technology project of Henan province (Grand No. 112102310550).

Help and Countermeasures of Remote Interconnect Automatic Alarm Garments to Elderly Healthy

L M.¹, Zhang K.S.^1,2, Zhai S.B.¹, Cheng X.H.¹

¹Dean's Office of Shaanxi Fashion Engineering University, Shaanxi 712046, P.R. China; ²College of Electrical and Information Engineering, Shaanxi University of Science and Technology, Shaanxi 710021, P.R. China

Aims: With the economic and social development, the phenomenon of social aging is becoming more and more serious. The issue of “falling but not supporting” for the elderly is even more worry. The bad results of fallen not only threaten the health and even life of the elderly, but also bring heavy burdens to the community. In order to solve the problem of health travel, it is imperative to study remote internet police clothing.

Methods: Remote Internet automatic alarm clothing system, using embedded technology, wireless communication technology and GPS technology. By identifying the human body posture and monitoring of human physiological parameters, achieve the purpose of remote Internetalarm. Using of three-axis acceleration sensor and gyroscope to build equipment of human activity sensing, it can determine the posture of the human body. When the elderly fall, the system will help through the phone to the other phone number automatically. The person you are seeking can ask for help. You can also use the APP to locate location.

Results: Remote Internetalarm clothing, using the flexible solar panels to supplement the energy, reflects the concept of saving energy; By judging the posture of the human body, identify whether the user falls over and monitor the physiological parameters of the user; It can call the user relatives and friends automatically and display GPS positioning information on their cell phones.

Conclusions: Remote Internetalarm clothing can identify the elderly fall and notify their relatives and friends. Therefore, it is of great significance to study this clothing that can identify body posture and monitor health status.

Acknowledgments: This paper was supported by the Key Research and Development Project of Shaanxi Province (2017GY-134) and Shaanxi Provincial Department of Education Project (17BY122).

Help and Countermeasure of Swimming Pool Drowning and self-help System to Swimmer ‘s Healthy Swimming

Zhang K.S.^1,2, Zhu F.X.¹

¹Department of Basic courses, Xi'an Peihua University, Shaanxi 710125, P.R. China; ²College of Electrical and Information Engineering, Shaanxi University of Science and Technology, Shaanxi 710021, P.R. China

Aims: With the development of society and the improvement of people's living standards, swimming activities have become a universal choice for people's health and entertainment. However, drowning accidents have occurred from time to time. In order to solve the swimming problem of swimmers and prevent the occurrence of drowning accident, it is imminent to study the system of swimming pool drowning and self-help.

Methods: Pool drowning and self-help system, using IOT technology, wireless communication technology and hyperboloid intersection positioning technology, by monitoring the swimmer's human physiological parameters, achieve the purpose of detecting abnormal automatic alarm. The wristband pulse sensor is used to detect the pulse of the swimmer. When an abnormal pulse occurs in the human body, the system locates the swimmer and releases the pre-filled special swimming ring after positioning so as to prompt the swimmer to surface quickly.

Results: Studying the special drowning self-help system, we use the wristband waterproof pulse sensor and dedicated swimming ring, reflecting the concept of scientific and technological innovation; It can monitor the pulse parameters of swimmers; Using hyperboloid intersection positioning locate swimmer in the pool position, and the information displayed on the shore of the display.

Conclusion: The swimming pool drowning and self-help system mainly includes power module, pulse detection module, positioning module, automatic control module and real-time display module. Without prejudice to swimmers, identifying the drowning behavior of swimmers can reduce the health damage and medical expenses. Therefore, it is of great importance to study a system that can detect the swimmer's pulse and save the drowning person from self-help.

Wristband Sleep Monitor Based on Healthy Sleep

Zhang K.S.^1,2, L M.¹, L C.H.¹, Cheng H.Y.¹

¹Dean's Office of Shaanxi Fashion Engineering University, Shaanxi 712046, P.R. China; ²College of Electrical and Information Engineering, Shaanxi University of Science and Technology, Shaanxi 710021, P.R. China

Aims: Sleep quality is essential to human health. One third of human life is spent in sleep. Many diseases are related to sleep disorders. How to effectively monitor people's sleep condition, improve their sleep quality and provides the basis for the early diagnosis of diseases related to sleep disorders draws more and more attention. In order to solve the problem of sub-healthy sleep, a wristband sleep monitoring device was studied.

Methods: Wrist strap sleep monitoring device, through the pulse sensor, the body surface temperature and humidity sensor to detect heart rate, body temperature and sweat secretion of the sleeper, thus judging the sleeper's sleep state. If sleep disorders trend is found, immediately start automatically off-axis vibration motor Vibrate or wireless Bluetooth headset to remind, in order to adjust the sleeper's sleeping position into a healthy state of sleep. Effectively monitor people's sleep status, thereby improving sleep quality.

Results: Based on the idea of healthy sleep, the wristband-type sleep monitoring device embodies the concept of scientific and technological innovation by embedding the embedded technology, data fusion technology and wireless communication technology for the purpose of relieving sub-healthy sleep. The device can monitor the sleepers’ sleep state and regulate sleep posture to ensure sleep health.

Conclusions: Wrist strap sleep monitoring device, with the role of real-time monitoring sleeper's sleep status and adjust sleep posture, can effectively improve the sleeper's sleep quality, and can prevent sudden illness during sleep, which is of great significance for the protection of the sleeper's physical and mental health.

Acknowledgements: This thesis is supported by the key research and development project of Shaanxi Province (2017GY-134) and the project of Shaanxi Provincial Department of Education (17BY122).

A Health Protection Method for Computer Operators

Cheng H.Y.¹, Zhang K.S.^1,2, L M.¹, L C.H.¹

¹Dean's Office of Shaanxi Fashion Engineering University, Shaanxi 712046, P.R. China; ²College of Electrical and Information Engineering, Shaanxi University of Science and Technology, Shaanxi 710021, P.R. China

Aims: In modern society, the computer has become an indispensable tool for people's life and work, but the computer is also increasingly becoming a “double-edged sword”: while it is convenient and fast for people's life and work, it is quietly endangering people's health, causing people's vision loss, joint damage, radiation damage, head and shoulder pain. In order to solve the computer operator's health problem on the computer, it is necessary to study the health protection method for computer operators.

Methods: The health protection method for computer operators includes the following steps: the computer pre-stores the health videos and plays the health videos through the speakers and the display; At the same time, the computer camera collects the images of the computer operator in real time and compares them with the preset health videos; If the overlap in a period of time continued high, then stop the video playback, the program ends, and the computer operator can continue to work properly. Otherwise, continue to contrast.

Results: The health protection method for computer operators is based on the concept of health on the machine, using embedded technology, image processing technology and infrared sensing technology, can detect the working hours of computer operators, and forcing them to carry out aerobics to protect the computer operator's health on the machine.

Conclusions: The health protection method for computer operators, using innovative design concept, with the role of forcing computer operator to adjust the attitude on the implementation of health care exercises, can effectively protect the health of computer operators, which is undoubtedly good news for today's computer operators.

Acknowledgements: This thesis is supported by the key research and development project of Shaanxi Province (2017GY-134) and the project of Shaanxi Provincial Department of Education (17BY122).

A Device that Prevents Medical Staff from Hanging Wrong Bottles

Zhai S.B.¹, Zhang K.S.^1,2, L M.¹, L C.H.¹

¹Dean's Office of Shanxi Fashion Engineering University, Shaanxi 712046, P.R. China; ²College of Electrical and Information Engineering, Shaanxi University of Science and Technology, Shaanxi 710021, P.R. China

Aims: When transfusion is given to a patient, the doctor usually writes a number on the patient's bottle. However, due to the occasional negligence of medical staff, incidents that hanging the wrong bottle often occurred, which caused great security risks to the patients. In order to solve this problem and avoid the occurrence of safety accidents, a device to prevent medical workers from hanging wrong bottles was studied.

Methods: This device uses internet of things technology, wireless communication technology and embedded technology to monitor patient medication for errors. It will automatically alert when something mistake. The method is to have the patient wear a wristband-type electronic tag with personal information; Paste the electronic tag with no information on the bottle surface, and placed the bottle in the read-write area, then use the medical management terminal to write the patient's personal information into the chip; Taking out the bottle according to the patient's room number and bed number, detect the electronic tag to judge whether the information on the bottle is consistent with the patient information with a reader; it will alert automatically when the result is false.

Results: The design concept of this device starting from the purpose of preventing medical staff from hanging wrong bottles, studying the special warning system, adopting the Internet of Things technology innovatively to locate and reflecting the concept of scientific and technological innovation. The system can monitor the electronic tags in real time and alert in time when the parameters are abnormal.

Conclusions: Medical staff comparing the information when take the patient's bottle, detecting the information of target patient again. After double testing, it will greatly reduce the error probability, to avoid the case of hanging up the wrong bottle. Therefore, the study of this device is of great importance to avoid secondary damage to the patient.

Acknowledgements: This thesis is supported by the key research and development project of Shaanxi Province (2017GY-134) and the project of Shaanxi Provincial Department of Education (17BY122).

Research on Automatic Dust Cleaning System for Automobiles Based on Dust Environment

Zhu F.X.¹, Zhang K.S.^1,2

¹Department of Basic courses, Xi'an Peihua University, Shaanxi 710125, P.R. China; ²College of Electrical and Information Engineering, Shaanxi University of Science and Technology, Shaanxi 710021, P.R. China

Aims: With the rapid development of automobile industry and highway traffic, the number of vehicles on the road is increasing, which makes people's life convenient, but also brings some problems. Respirable suspended particles caused by the passage of automobile can seriously destroy air quality and cause respiratory diseases. To solve this problem, it's necessary to study an automatic dust cleaning system for automobiles.

Methods: Automatic vacuuming system, using the embedded technology, data fusion technology and bus communication technology, detect the dust concentration in the air with dust concentration sensor. If the dust concentration exceeds the standard, start the special vacuum cleaner for dust collection immediately. Firstly, start the dust sensor installed under the car frame to detect the dust concentration on the road, then input the data into the microprocessor; secondly, the microprocessor compared detection values the dust sensor obtained with the standard value; finally, the microprocessor control folding electric telescopic baffle down or up according to the dust weather exceed the standard, to control the opening or closing of the vacuum device.

Results: This system is based on the concept of environmental protection, starting from the purpose of reducing dust haze to ensure people's outdoor health. It adopts embedded technology, data fusion technology and bus communication technology, which reflects the concept of scientific and technological innovation. It can monitor dust and haze in the air in real time, and vacuum dust automatically when the parameters are abnormal.

Conclusions: The automatic dust vacuum system for automobile, using innovative design concepts, has the characteristics of removal dust on the road quickly, clean roads effectively, and can save human and financial resources.

Prediction Model of Pathogenic Gene of Coronary Heart Disease Based on Machine Learning

Huang Y.L.¹, Sajid A.²

¹Information Center, Beijing University of Chinese Medicine, Beijing, China; ²Department of Computer Science, University of Education, Lahore, Pakistan

Aims: An important purpose of bioinformatics is to help humans to gain insight into the process, genetic characteristics, and potential treatment of disease. However, it is often found that pathogenic genes are often found. It is a complex and arduous task, such as the disease-causing gene of coronary heart disease.

Methods: Based on the comprehensive collection of gene expression data, an improved direct push machine learning model is proposed to detect the potential risk genes of coronary heart disease. The inner layer is used to obtain the contribution degree of the gene expression profile of the coronary heart disease tissue from the multidimensional degree; in the outer layer learning, the contribution of the inner layer will be learned with the data obtained by the machine learning model to obtain the sequencing result of the pathogenic gene.

Results: Experimental verification of the disease and pathogenic gene data in omim database. The experimental results show that the method achieves good prediction results and uses the method for the case analysis of coronary heart disease, and predicts two new potential pathogenic genes.

Conclusions: This study summed up the research and application of machine learning technology in the research of CHD, and proposed the research idea in machine learning on CHD.The experimental results show that the accuracy of machine learning is better than that of traditional methods in the prediction of pathogenic gene.

Acknowledgements: Supported by a project grant from Beijing University of Chinese Medicine (Grand No. 2016-JYB-QNJSZX0005).

Keywords: Coronary heart disease, Machine learning, Pathogenic genes prediction

Prioritisation model for CHD pathogenic genes based on machine learning.

A Remote Health Monitoring Mechanism for Chronic Patients Based on Software Defined Wireless Sensor Network

Fan J.J.¹, Zhao J.G.^1,2, Liang M.G.²

¹Information Engineering Institute, Hebei Institute of Architectural Engineering, Zhangjiakou City, China; ²Institute of Information Science, Beijing Jiaotong University, Beijing City, China

Objectives: In view of the fact that chronic patients are not suitable for long-term hospitalization and need to regularly detect the corresponding physiological indicators, a remote health monitoring terminal based on wireless sensor network is designed.

Methods: This article covers the activity area of ​​the patient by deploying the sensor network in the patient's home or in a certain outdoor area. Network-based patients choose to wear wireless sensor nodes that can be tested for physiological indicators based on illness and health status. These sensor nodes can monitor the patient's important physiological indicators such as blood pressure, pulse, heart rate, and blood oxygen concentration. The data obtained by the receiving node is simply merged locally and then transmitted to the hospital through the Internet or other communication network through the base station.

Results: Greatly enhance the convenience of medical treatment of chronic patients, effectively reducing the morbidity of sudden illness.

Conclusions: The remote health detection server and the monitoring system of the hospital carry out real-time analysis of the physiological indexes of each monitored person through the diagnosis expert. The system to determine the patient's health status, and given medical advice if abnormal parameters are found, alarm and quick ambulance.

Acknowledgements: Supported by the National Natural Science Foundation Project: SDN-based cloud computing data center network scalability research, (Grand No. U1636109).Education Department of Hebei Province youth fund project, project number: QN20131148.

The Analysis of SF3B3 Mutation in Lung Cancer by Bioinformatic

Huang G.Q., Wang L., Wang D.K., Xue J.Y., Sun Y., Li Y., Wu Q., Cao D.F.

Institute of Advanced Technology, Heilongjiang Academy of Sciences, Harbin, China

Objectives: There is a high prevalence of lung cancer in China, which is associated with a long-term of smokers, air pollution and genetic factors. SF3B3 is an important part in splicing factors, it plays an important role in the prespliceosome assembly and identification of branch point in intron, which is likely to be a novel target for clinical treatment of cancer. It has been shown several mutated in various malignancies and have a great influence on clinical outcomes. The aim of this study was to analyzed the change of biological characteristics and physicochemical properties on SF3B3 (H804Y) mutation in lung cancer.

Methods: The website of Expasy, the Swiss-PdbViewer and PyMOL.

Results: By comparing the mutational and transcriptomic profiles, we identified novel mutant of SF3B3 (H804Y) in a blood sample of lung cancer. Compared with wild type, the theoretical pI was reduced from 5.13 to 5.11, the extinction coefficient increased from 101745 to 102235, the instability index decreased by 0.19, the Grand average of hydropathicity (GRAVY) was increased 0.001, besides, the steric hindrance also varied.

Conclusions: In conclusion, the SF3B3 (H804Y) mutation increases its stability which could caused difficult to metabolize relatively; the steric hindrance increases relatively may affected normal biological function of SF3B3. Therefore, we suggested that SF3B3(H804Y) mutation is potential key drivers in the development and biological behavior of lung cancer.

Fluorescence Quenching for Metronidazole Detection in Pharmaceuticals and Rabbit Plasma Based on Carbon Nanodots

Yang X.P.¹, Liu M.X.¹, Tang F.L.¹, Xu H.¹, Yang Z.L.¹, Liao X.J.²

¹College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong, China; ²Exposure and Biomonitoring Division, Health Canada, Ottawa, Canada

Objectives: The aim of this work was to synthesize carbon nanodots with strong fluorescence and to develop a method for the determination of metronidazole in pharmaceuticals and plasma based on the fluorescence quenching effect of metronidazole on carbon dots.

Methods: Fluorescent carbon nanodots (FCNs) were synthesized with a green approach using gardenia as a carbon source through one-step hydrothermal method. FCNs were characterized by UV-vis absorption spectra, photoluminescence (PL), fourier transform infrared spectroscopy (FTIR) as well as X-ray photoelectron spectroscopy (XPS).

Results: The proposed method displayed a wide linear range from 0.8 to 225.0μM with a correlation coefficient of 0.9992 and a limit of detection as low as 279nM, respectively. It was successfully applied to the determination of MNZ in commercial tablets and rabbit plasma with excellent sensitivity and selectivity.

Conclusions: Strong blue-emitting FCNs have been synthesized and applied to the detection of metronidazole in commercial tablets and rabbit plasma. The major attributes of the proposed method is simple, cost-effective, convenient and environmentally benign, which indicated its potential applications in the clinical analysis and biologically related study.

Acknowledgements: Supported by a project grant from the National Natural Science Foundation of China (Grand No. 21777130).

A Medical Robot Positioning and Tracking System Based on Computer Intelligent Algorithm

Chen S.Y.

School of Mathematics and Computer Science, Gannan Normal University, Ganzhou, China

Objectives: By using computer intelligent algorithm to locate and track medical robot, it is easy to carry out difficult operation or the examination of patient's later vital signs, which has an important role in the development of medical industry.

Methods: The learning process of RBF neural network algorithm converges fast and has good classification ability, and the K-means clustering algorithm can converge to local optimal, so this paper adopts the computer intelligent algorithm based on the combination of computer RBF neural network and K-means clustering algorithm to provide effective training for the position and posture of the medical robot movement and converge to locally optimal positioning coordinates.

Results: The simulation results show that this method can make the positioning coordinate of medical robot converge to the local optimal, and the tracking effect is obvious.

Conclusions: The proposed algorithm improves the speed and precision of the positioning and tracking of medical robot, plays the role of medical robot and improves the level of medical technology.

Research on Hospital Medical Big Data Information System Based on Data Mining

Deng B.¹, Yan G.Q.¹, Guo Y.H.², Wu L.G.¹, Wang R.³, Wu C.B.⁴

¹The Third Affiliated Hospital of the Qiqihar Medical University, Qiqihar, China; ²The Second Affiliated Hospital of the Qiqihar Medical University, Qiqihar, China; ³The First Affiliated Hospital of the Qiqihar Medical University, Qiqihar, China; ⁴Department of Computer, Qiqihar Institute of Engineering, Qiqihar, China

Objectives: In order to solve the storage and rapid and effective use of large medical data, a hospital medical big data information system is constructed to improve the efficiency of the work.

Methods: On the basis of big data analysis and cloud computing technology, the data mining module is designed by six steps and embedded into the hospital medical big data information system.

Results: This system can realize the association analysis of case data, medical cost analysis, data mining analysis of large scale medical equipment fault diagnosis, and other functions, and solves the problem of medical data classification difficulty and low utilization efficiency.

Conclusions: It can effectively complete the sorting, classification, integration and analysis of big data, can provide true and reliable reference information for hospital managers, medical care personnel and even patients, and is of great significance to the decision-making of the hospital and the improvement of the business level.

Acknowledgements: Supported by a project grant from Scientific Research Project of Qigihar Science and Technology Bureau (Grand No. GYZD-2015006).

A Hospital Medical Information Sharing Platform Based on ETL Technology

Guo Y.H.¹, Zhao Y.H.¹, Wu C.B.², Deng B.³, Yan G.Q.³, Wang R.⁴, Sui Y.¹, Xiu Y.H.⁵

¹The Second Affiliated Hospital of the Qiqihar Medical University, Qiqihar, China; ²Department of Computer, Qiqihar Institute of Engineering, Qiqihar, China; ³The Third Affiliated Hospital of the Qiqihar Medical University, Qiqihar, China; ⁴The First Affiliated Hospital of the Qiqihar Medical University, Qiqihar, China; ⁵Qiqihar Medical University, Qiqihar, China

Objectives: The objective is to promote the development of information sharing level in the hospital medical area, and improve the ability of information sharing in the hospital medical area.

Methods: We should study all cases in the hospital medical area and find out the typical cases as the demonstration cases, use ETL technology as an information exchange engine, construct a hospital medical information sharing cloud platform, sum up the effective treatment information and realize the sharing of medical information in the region.

Results: Through the overall summary of the information exchange engine in the hospital and then pushing it to the regional information processing engine, the information interaction in the whole area is realized. The medical information collected by each hospital is interactively shared, and the patients and the hospital are finally benefited.

Conclusions: The construction of information integration platform realizes the unified display of medical information produced by patients at different times and hospitals, strengthens the integration of medical information, and improves the medical and health level in the region.

Acknowledgements: Supported by a project grant from Scientific Research Project of Qigihar Science and Technology Bureau (Grand No. GYZD-2015005).

Smart Watches for Measuring Physiological Features

Chen Y., Chang Z.W., Li S.Q.

Sate Grid Sichuan Electric Power Research Institute, Chengdu 610041, China

Aims: Day and night temperatures, humidity, atmospheric conditions and ultraviolet radiation are very changeable in mountainous areas in plateaus. Staff members are prone to suffer from altitude stress, cold, UV burns, etc. due to inaccurate judgement or lack of experience. A means to safeguard the lives of staff under complex environment is therefore essential, which can be used to protect accidents from happening.

Methods: To what extent the body can handle under different environments varies depending on individuals, thus the workload allocating to each person shall be balanced. However, in many cases, staff members may ignore the limit of their body's endurance because of team action and suffer from severe consequences such as fatigue, asthma, dizziness and increase in heart rate. Blood oxygen, heart rate and electrocardiograph (ECG), these three physiological signals can be used to perform pathological analysis on the above phenomenon. Further, a number of physiological parameters like heart rate variability, blood flow velocity, blood oxygen level and cardiopulmonary coupling are able to be analyzed via the above signals. Hence, by collecting health data including blood oxygen, heart rate and ECGs using a smart watch with locally integrated pathological algorithms, such parameters as blood oxygen level, arrhythmia, blood pressure and cardiopulmonary coupling degree can be worked out. In hospitals, ECG signals are usually collected through 12 leads whereas for smart watches, two-lead ECGs are adopted as such complex operation is hard to be achieved in smart watches.

Results: The physiological-feature-based method for body health management under complex environments is presented innovatively with smart watches as the collecting terminal and with mobile applications as means of interaction. Reviewing the real-time and historic data of the wearable devices enables staff members to have a timely understanding of the complex environment and their own physiological features.

Conclusions: This scheme is highly extensible, and has built theories on health algorithms and applied in some scenarios, e.g. smart bracelets applied in field work in grids. In the next step, new physiological features will be extracted and health algorithms will be further developed.

Acknowledgements: Supported by Key R&D Projects of Sichuan Province (No. 2017GZ0068), and a project of State Grid Sichuan Electric Power Company.

Internet Plus Medical Based Information Data Processing Algorithm of Modern Cloud Hospital

Wang R.¹, Hu K.¹, Guo Y.H.², Lv P.¹, Zhang X.¹, Deng B.³, Yan G.Q.³, Wu C.B.⁴

¹The First Affiliated Hospital of the Qiqihar Medical University, Qiqihar, China; ²The Second Affiliated Hospital of the Qiqihar Medical University, Qiqihar, China; ³The Third Affiliated Hospital of the Qiqihar Medical University, Qiqihar, China; ⁴Department of Computer, Qiqihar Institute of Engineering, Qiqihar, China

Objectives: The cloud computing can provide massive data support for doctors in clinical diagnosis and the research and development of drugs, so a Internet plus medical based information data processing algorithm of modern cloud hospital is put forward.

Methods: The data association rule algorithm is used to deal with the hospital information data, the hospital file storage and hospital data association analysis are effectively combined, and the Internet plus medical based information data processing system of modern cloud hospital is constructed based on the cloud technology.

Results: A set of cloud hospital information data processing system is developed, and the correlation between type 2 diabetes and its complications is analyzed by using the hospital information data processing system of cloud platform. The precondition for designing association rules is type 2 diabetes. The support degree is set to 5%, and the confidence degree is set to 30%. The results of column type analysis are obtained.

Conclusions: The high performance services generated by cloud platform provide a brand-new way for storing, retrieving, processing and analyzing data, which can rapidly improve the function and efficiency of data processing. Therefore, using cloud computing platform to store and process data and obtain the association relationship between the disease and complications has a very important research value.

Acknowledgements: Supported by a project grant from Scientific Research Project of Qiqihar Science and Technology Bureau (Grand No. GYZD-2015008).

The Observation of the Immunotherapy Effect of Recurrent Respiratory Tract Infection in Children

Shao H.L.

Department of Pediatrics, Yinzhou People^’s Hospital, Ningbo, China

Objectives: The purpose is to observe the immunotherapy effect of recurrent respiratory tract infection in children.

Methods: 72 children with recurrent respiratory tract infection in the last year of pediatrics in our hospital were selected as the research objects. According to different treatment methods, they were divided into routine group and immunization group, and there were 36 cases in each group. The routine group was given routine treatment, and the immunotherapy was strengthened in the immunization group. The clinical efficacy, serum immunoglobulin level, T lymphocyte detection results and recurrence times were compared between the two groups.

Results: For the serum immunoglobulin level, T lymphocyte detection results and total effective rate of two groups after treatment, the immunization group is high. However, for the recurrent frequency of two groups within one year after treatment, the immunization group is low. The contrast difference has statistical significance (p<0.05).

Conclusions: The immunotherapy effect of recurrent respiratory tract infection is obvious, which can effectively improve the serum immunoglobulin level of children patients, improve the T lymphocyte detection results, and significantly reduce the recurrent frequency. It is suggested that clinical application and promotion should be carried out.

A New Robust and Efficient Evolutionary Algorithm to Solving Protein Structure Prediction Problem

Ding C.C., Zhong B.R., Chen Y.

School of Computer Science, Yangtze University, Jingzhou 434023, China

Objectives: In this paper, we study the difference between the structures obtained using learning algorithms based Bayesian network and the relationship of that structures with the interdependences in the variables which the function defines. We also investigate the changes in the pattern of the dependencies caught by the algorithms during their evolution. We know that the problem of determining the protein native structure is called protein structure prediction problem.

Methods: In experiments we use a protein folding model which is called the hydrophobic-polar (HP) model. To solve the problem, a protein model is chosen and an energy is associated to every possible protein fold.

Results: In general, the experiment results show that the type of learning algorithm could produce great differences in the models learned and in the performance of learning algorithms. In particular, when the learning algorithms is provided with enough information through the selected individuals, it can obtain accurate structural models exactly related to the structure of the original problem. However, the learning technique is not always able to obtain accurate structures even when the population size is large. The results suggests the existence of certain limits related to the learning techniques.

Conclusions: In addition, this fact is significant because usually learning algorithms based Bayesian network are thought to correctly reflect the dependencies that exist in HP Protein Model Problem.

Acknowledgements: This paper was supported by Scientific Research Projects of Hubei Provincial Department Of Education (grant no. Q20151312).

Numerical Simulation of Transient Heat Transfer in Biologic Tissues Subject to Freeze-Thawing in Hot and Humid Climates

Wang M.F., Cai W., Yan K.J., Hu J.J., Zhang W.J.

Ningbo University of Technology, Ningbo, China

Objectives: The bio-heat transfer is the focus of biomedicine science. However, little literature is available on the thermal effect of living tissue. The objective of the paper is to obtain the dynamic temperature distribution of the freeze-thawing biologic tissues.

Methods: A mathematical model for freeze-thawing was established and solved using ANSYS 15. The temperatures of the pig lung and liver samples were dynamic estimated.

Results: (1) The convection heat transfer coefficient was proportional to the diameter of blood vessel. It increased in heat transfer coefficient with the increase of blood flow rate. (2) Heat transfer was become increasing strong as the blood vessel was near to the epidermis of biologic tissue. (3) The cooled field of multiple blood vessels was significantly less than that of a blood vessel, and the shape of frozen ball became quite irregular.

Conclusions: Blood flowing through blood vessels acts as a convective fluid and helps to prevent any buildup of excess heat inside the tissues. The heat carried by the blood is determined by the flow velocity, the diameter and numbers of the blood vessel.

Acknowledgements: This research was supported by Zhejiang Provincial Natural Science Foundation of China under Grant No. LY15E080016 and funded by Beijing Key Lab of Heating, Gas Supply, Ventilating and Air Conditioning Engineering (No. NR2015K07). Programs supported by Ningbo Natural Science Foundation (No. 2016A610113) and Zhejiang Provincial Undergraduate Science and Technology Innovation Project (No. 2017R424024).

Immunologic Response Induced by Cryotherapy for Double Primary Carcinoma

Wang M.F., Cai W., Hu J.J., Yan K.J., Li Z.J.

Ningbo University of Technology, Ningbo, China

Objectives: To assess the anti-tumor immune response of cryotherapy for sarcoma cancer. The objective of this work was to present the effect of cryotherapy combined with immunological treatment on tumor-bearing mice.

Methods: KM mice were inoculated subcutaneous with S180 sarcoma cells, and were randomly divided into four groups. For the treatment of tumors were cryotherapy (Group A), immunotherapy (Group B), cryo-immunotherapy (Group C) and saline control group (Group D). After 15days, four groups of mice were rechallenged with S180 sarcoma cells. The therapeutic effect was assessed by the survival time and TNF-α content of mice.

Results: In Groups A, B, C and D, the surviving time (d) of mice was 89.6±6.75, 91.8±11.24, 109.7±8.98 and 58.1±9.56 respectively (p<0.01); the serum TNF-α (pg/mL) was 6.765±0.847, 7.983±0.831, 9.792±0.681 and 4.7237±0.503 respectively (p<0.01).

Conclusions: Cryo-immunotherapy could enhance anti-tumor immunity and prolong the surviving time of mice with double primary tumors.

Acknowledgements: This research was supported by Zhejiang Provincial Natural Science Foundation of China under Grant No. LY15E080016 and funded by Beijing Key Lab of Heating, Gas Supply, Ventilating and Air Conditioning Engineering (No. NR2015K07). Programs supported by Ningbo Natural Science Foundation (No. 2016A610113) and Zhejiang Provincial Undergraduate Science and Technology Innovation Project (No. 2017R424024).

Research on Medical Diagnosis System Based on Big Data

Hao J.J.¹, Zhang K.S.^1,2

¹Dean's Office of Shaanxi Fashion Engineering University, Shaanxi 712046, P.R. China; ²College of Electrical and Information Engineering, Shaanxi University of Science and Technology, Shaanxi 710021, P.R. China

Aims: With development of telecommunication mechanics, the information construction hospital has been improved continuously, which brings great convenience to the patients and doctors. This research established an online client-provider interactive platform to make a convenient and effective process of therapy feedback and pesticide effect, thus a continuous improvement and optimization will be made in the aspect of therapy schedule and treatment prescription. A subsequent update of diagnosis and treatment scheme can be established based on the previous interactive platform to make the hospital medical system more intelligent and effective. The therapeutic process of patients will become more seasonable.

Methods: Based on big data, the medical diagnosis system mainly includes several parts like diagnosis scheme database; information combination between diagnosis scheme database and patient inspection result, then transfer to prescription generation module; prescription generation nodule transfer information to patient pharmacy module; patient pharmacy module transfer information to information feedback module; information feedback module transfer information to diagnosis scheme database; patient inspection result also can be transferred to patient information database and both diagnosis scheme database and patient information database will send information to hospital information system.

Results: This medical diagnosis system was established through medical big data. Based on medical diagnosis system of big data, the research correlated all of the inspection results by patient ID and then combined the diagnosis scheme database to provide one or several kinds of prescriptions. Finally an optimized prescription which was corrected by doctor will be proposed, thus make the whole process more convenient and faster.

Conclusions: This kind of medical diagnosis system provides a database with more medical reference to doctors, and establishes a more convenient hospital environment.

Acknowledgements: The system aforementioned is under the support of: Key research and development planned project of Shaanxi province (2017GY-134) and Research project of Shaanxi Education Department (17BY122).

Research on Risk Preference and Bounded Rationality Based on Psychology Experiments

Meng H.

Zhejiang University, Hangzhou, China

Objectives: To investigate risk preference and bounded rationality among people, we designed a series of experiments to explore whether people made rational decision when they were influenced by others. Therefore, we can also do research on the intrinsic mechanism under the risk type decision.

Methods: 50 individuals were enrolled to finish two different experiments. In the first experiment, they were asked to finish the self-report inventory about feeling seeking, also they had to finish Advanced Balloon Analogue Risk Task so that we could divide them into 3 parts according to their risk tolerance. The second experiment designed an environment that people with different risk preference could compete to gain profit, which could help us know if rational people were influenced by others and did the irrational things.

Results: The result of first experiment was that the inventory results were highly correlated with the division of people, also we could observe a series of phenomenon suggested by behavior finance. The second experiments showed that rational people would increase their risk tolerance when they were competing to gain more profit.

Conclusions: This article proves that irrational behavior is the source of the financial bubble. On the other hand, it may introduce a new way of simulation by using psychology experiments to do research on behavioral finance.

A Synthetic and Systematic Method to Screen of Rhizoma Coptidis Processed by Fructus Evodiae for Antihepatocarcinoma Effect

Xu B.L.^1,2,3,4, Ji Y.B.^1,2, Wang R.⁵, Li W.L.^3,4, Yang X.J.³, Wang X.^3,4

¹Post Doctoral Research Center of Materia Medica, Harbin University of Commerce, Harbin, China; ²Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin, China; ³School of Pharmacy, Harbin University of Commerce, Harbin, China; ⁴Key Laboratory for Drug Research of Prevention and Treatment of Geriatric Diseases, Harbin University of Commerce, Harbin, China; ⁵Integrated Department, Harbin Stomatological Hospital, Harbin, China

Objectives: A synthetic and systematic approach was established to interpret the effective materials of TCM is multiple active components alignment rather than a single component.

Methods: Rhizoma Coptidis processed by Fructus Evodiae (Yuhuanglian) was used, which was better consistent for antihepatocarcinoma than Rhizoma Coptidis (Shuanghuanglian) in traditional Chinese clinical. Immuno-histochemistry, ELISA, UPLC-ESI-MS/MS, MTT, FITC/PI and FCM were applied invitro and vivo.

Results: Our data demonstrate that Yuhuanglian had the trend of pathological changes ease of Solt-Farber model, decreased Bcl-2 and PCNA expressions, increased Bax expression in liver and reduced the contents of tumor makers of AFP, AFP-L3, GP73 and TK1 in serum. Berberine, palmatine and jatrorrhizine reached maximum concentration at the same time in plasma of the pathological condition, which indicated that the three components could have synergistic effect, and the ratio of them was 4:2:1. In vitro, multiple active components alignment (berberine: palmatine: jatrorrhizine=4:2:1) versus a single component was conducted on SMMC-7721 cell, and the results showed that the former could better suppressed cell growth and increased apoptosis rate.

Conclusions: Multiple active components alignment might be better as effective materials. Therefore, it's a good strategy of combining vivo and vitro pharmacodynamics, particularly synergistic components of pathological state.

Acknowledgements: Supported by a project grant from the Doctoral Scientific Research Foundation of Harbin University of Commerce (Grand No. 13DL024), the Postdoctoral Fund of Heilongjiang Province (Grand No. LBH-Z13121), Harbin Applied Technology Research and Development Project (Grand No. 2016RAQXJ009), and The Scientific Research Foundation of Harbin University of Commerce (Grand No. 17XN028).

The Role of NF-kB Signaling Pathway in Colitis Related Colon Cancer and the Intervention of Traditional Chinese Medicine

Ji Y.B.^1,2, Xu B.L.^1,2,3,4

¹Post Doctoral Research Center of Materia Medica, Harbin University of Commerce, Harbin, China; ²Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin, China; ³ School of Pharmacy, Harbin University of Commerce, Harbin, China; ⁴Key Laboratory for Drug Research of Prevention and Treatment of Geriatric Diseases, Harbin University of Commerce, Harbin, China

Objectives: The purpose is to explore and reveal the action mechanism of NF-kB signaling pathway in colitis related colon cancer.

Methods: Firstly, the cells are cultured and transfected, and the total cell protein is extracted after the pancreatic enzymes digest the cells. Then, the dual-luciferase reporter gene is determined, and the control value is taken as the base number to draw the picture. The LPS is used to process colon, and extract protein and RNA. The infection model of escherichia coli is obtained and the co-immunoprecipitation is finally carried out.

Results: Ck8 regulates the activation of TLR4-induced NF-kB signaling pathway, which can inhibit the infectious conjunctivitis caused by escherichia coli. The intervention of traditional Chinese medicine is to regulate the downstream NF-kB signal transduction. The traditional Chinese medicine, such as kuijieling, Qingchang Huashi recipe, Xiezhuo Jiedu decoction and Shaohuang Anchang decoction, can influence gene expression downstream of signaling pathway, and directly or indirectly inhibit the activation of NF-kB and reduce the inflammatory response.

Conclusions: Intestinal pathogenic bacteria mainly play a role through TLR mediated NF-kB signaling pathway. CK8 can inhibit the activation of NF-kB signaling pathway induced by a variety of TLR agonists.

Acknowledgements: Supported by a project grant from the Doctoral Scientific Research Foundation of Harbin University of Commerce (Grand No. 13DL024), the Postdoctoral Fund of Heilongjiang Province (Grand No. LBH-Z13121), Harbin Applied Technology Research and Development Project (Grand No. 2016RAQXJ009), and The Scientific Research Foundation of Harbin University of Commerce (Grand No. 17XN028).

Design and Optimization of Monitoring System for Agricultural Environment with Wireless Sensor Network Technology

Zhan S.B., Li X.T.

Shenzhen Institute of Information Technology, Shenzhen, China

Objectives: Agriculture is the basic industry of the national economy. The features of agricultural environment monitoring is objects variety, widely and remotely distribution, faraway from urban and weak communication. In order to monitoring agriculture environment and obtaining the real time accurate field data, wireless sensor network (WSN) technology is used. By arranging large scale of sensor nodes in farmland and monitoring agriculture environment continuously, the data can be sent to observer by base station which can provide a reliable basis for cultivation plant and field management. However, because there are different kinds of sensors like temperature sensors, light sensor, humidity sensor, each sensor node has different initial energy. The power consumption of perception, collection and transmission of different sensor is different as well. In this paper, a monitoring system with WSN technology suitable to agriculture environment is designed. At the same time, the optimization of power consumption for the monitoring system is considered.

Methods: A self-awake algorithm based on the message drive is designed, which can effectively avoid power consumption for each sensor node. C8051F340 and XBee-PRO are selected as main control chip and transmission module in hardware, environment paraments are collected by ZigBee. With the design of the node's hardware and software, the node's capability of wireless communication, data acquisition, processing, and the command group can be operated smoothly.

Results: It is verified from experiment that nodes have less bit error rate and power consumption. The sample frequence temperature and soil humidity could be reduced 53.5% and 45.0%, power consumption could be reduced 76.2% with compare of continuous sampling.

Conclusions: Though the analysis of the test results, the monitoring node can be extended into a variety of complex agriculture environment. It is shown that the monitoring system designed with WSNs technology which proposed in the paper can be applied in agriculture environment monitoring to collect the needed parameters conveniently.

Acknowledgements: Supported by Shenzhen strategic emerging industry development funds(Grand No. JCY20160307100530069).

Design of Pressure Sensor and Clinical Application Based on Graphene Material

Huo H.Y., Tan X.

Shenzhen Institute of Information Technology, Shenzhen, China

Objectives: In biomedical engineering research, pathological diagnosis and bed monitoring, the pressure measurement of various parts of the organism is an important means of pathological analysis and research. But because of the particularity of the pressure measurement in the organism, the performance of the pressure sensor is very high. Besides stability and continuity, it is also required that the pressure range of medical measurement is generally within 400mmHg, and it requires a good test characteristic within 10mmHg. The sensing pressure sensitive thin films made by traditional silicon based materials and the manufacturing process are difficult to meet the accuracy requirements. Therefore, the preparation of new materials has become an important solution in this field.

Methods: In this study, a new material of graphene was used as a sensor sensitive film instead of silicon based materials. On this basis, a silicon based structure compatible with graphene film is designed. Finally, a compatible process for the transfer of graphene film to silicon based structure is designed. A complete design method of clinical pressure sensor with new materials is established.

Results: The design of the graphene pressure sensor, which is compatible with the silicon based process, doubly reduces the area of the chip and can be more effectively applied to medical devices. At the same time, using the excellent mechanical and electrical properties of graphene materials, increasing the resistance change rate from physical mechanism, improving the sensitivity of sensors and improving the accuracy of sensor measurement. The maximum error of the data is zero point two percent by the laboratory test.

Conclusions: The measurement results show that the use of graphene materials to prepare sensor sensitive film can effectively improve the measurement accuracy. Compatible silicon based structure and process flow have high stability and can be effectively applied to various kinds of high-precision medical pressure sensors, and effectively improve the monitoring of clinical biological signs.

Acknowledgements: Supported by Shenzhen strategic emerging industry development funds (Grand No. JCY20160307100530069) and Shenzhen Basic Research Project for Development of Science and Technology (No. JCYJ20160530141956915).

Research on the Symptoms and Treatment of Ankle Injury in Aerobics Training

Liu J.Y.

Department of Physical Education, Changchun University, Changchun, China

Objectives: The purpose is to study the symptoms and treatment measures of ankle injury in aerobics training.

Methods: 160 athletes with unilateral ankle injury in aerobics training from 2015 to 2016 were selected. The random digital table method was used to divide the cases into the experimental group and the control group, and there were 80 cases in each group. The control group used Yunnan Baiyao aerosol, and it was guaranteed to spray two times a day. The external application of the prescription for promoting blood circulation and stopping pain should be selected for the experimental group. The two groups were treated for 7days, and the effect was observed scientifically.

Results: The total effective rate of the experimental group is 92.50%, the total effective rate of the control group is 81.25%, and the clinical treatment effect of the experimental group is obviously better than that of the control group.

Conclusions: The treatment of external application for promoting blood circulation and removing blood stasis can effectively improve the ankle injury of aerobics athletes.

A Rehabilitation Training Method of the Knee Joint Injury of Basketball Players

Zhang M.¹, Ye Q.²

¹Department of Exercise and Training, Nanjing Sport Institute, Nanjing, China; ²Department of Sport and Health Science, Nanjing Sport Institute, Nanjing, China

Objectives: The purpose is to explore the rehabilitation training method and application effect of the knee joint injury patients of basketball players.

Methods: 240 patients with knee injuries were observed, and all the patients were basketball players. The patients were divided into the study group and the reference group by the random digital table method, and there were 120 cases in each group. The reference group was given the conventional postoperative exercise, and the study group was given the targeted rehabilitation training. The good rate of treatment, the knee joint function score before and after operation and the joint range of motion were compared between the two groups.

Results: After rehabilitation training, the good rates of the study group and the reference group are 93.33% and 83.33%, respectively, and the difference is statistically significant (p<0.05). The Lysholm scores at various time periods after operation in the study group are better than those of the reference group (p<0.05). The joint range of motion of the patients after operation of the study group is better than the reference group (p<0.05).

Conclusions: Scientific and effective rehabilitation training can effectively relieve the pain of the patient, promote postoperative knee function and recovery of the joint range of motion, reduce the incidence of complications and accelerate the rehabilitation course.

A Flexible Wearable Strain Sensor Based on Graphene Microstructures

Zhan S.B.

Shenzhen Institute of Information Technology, Shenzhen, China

Objectives: The purpose of this paper is to design a flexible wearable strain sensor, which can be applied to human motion detection, personal health and medical monitoring and so on. The significant advantage of the designed structure is to achieve high performance sensitivity.

Methods: In this paper, a flexible strain sensor based on PDMS with graphene microstructures was proposed, and the fabrication method was designed. In order to improve the sensitivity to the loaded pressure, the PDMS substrate with the microstructure embedded inside was designed, so that the three-dimensional structure of the grapheme film could be formed. Three different microstructures, cylindrical, snake and Pyramid, were designed to compare the structural properties.

Results: The test results show that the structure can achieve up to 30% of the tensile variables, which can meet the complex environment of the skin surface of the human body. At the same time, the results show that the relative resistance change of pyramid type structure is up to 200%, which is better than that of cylindrical and snake structures.

Conclusions: The proposed wearable strain sensor can detect biophysical signals, such as human joint movement, facial muscle movement, pulse, respiration, phonation and so on. The related research can provide a new way for high performance and low cost flexible wearable materials and device fabrication.

Acknowledgements: Supported by Shenzhen strategic emerging industry development funds (Grand No. JCY20160307100530069).

Research on Rehabilitation Measures for Joint Ligament Injury of Aerobics Athletes

Zuo N.N.

School of Physical Art, Jilin Sport University, Changchun, China

Objectives: The purpose is to explore the causes and rapid rehabilitation methods of ankle ligament injuries of aerobics athletes.

Methods: 50 aerobics athletes with ankle ligament injuries treated by bone surgery from September 2016 to April 2017 were selected. They were randomly divided into the control group and the observation group, and there were 25 cases in each group. The control group adopted conventional rehabilitation training, and the observation group adopted the method of manipulation combined with conventional rehabilitation training, and then the clinical efficacy of two groups of patients was compared.

Results: Patients with ankle ligament injury in the observation group uses the MBI score, and its clinical total effective rate is much higher than that of the control group, and the difference is statistically significant.

Conclusions: The effect of ankle ligament injury is better by means of manipulation combined with the conventional rehabilitation training, which is worthy of clinical promotion.

Research on the Application of Clustering RSF Algorithm in Medical Image Segmentation

Liu K., Hu R.J.

School of Electrical Engineering, Southeast University, Nanjing, China

Objectives: A single traditional algorithm has been unable to meet the needs of medical image segmentation. In order to overcome the above difficulties, this paper combines the clustering thought and RSF level set model to improve the image segmentation technology, so as to make it play a better role in practical applications.

Methods: In view of the fast convergence of clustering RSF algorithm, the clustering RSF algorithm is applied to the experiment of X-ray image segmentation. And then, we compare it with the traditional X-ray image processing methods, divide 10 random small areas on the image, and introduce noise to process on the computer.

Results: After the X-ray image segmentation by using clustering RSF algorithm experiment, the accuracy and resolution are obviously higher than the images processed by traditional methods. At the same time, it solves the problem that the grayscale and shape of lesions in the medical image are similar to the normal tissue in the surrounding area and the problem not easy to be distinguished by the naked eye, so that the lesions are clearly presented.

Conclusions: The practical application of clustering RSF algorithm in X-ray images, fault CT images and ultrasound images proves that the algorithm improves the quality of medical image segmentation and can make us effectively obtain useful information of human organs in anatomic form, biological chemistry and physiological functions.

The Influence of Life and Health Environmental Uncertainty on the Relationship Between Medical Financial Flexibility and Internal Control in Hospital

Tang W.P., Wang A.Q.

School of Management, Jilin University, Changchun, China

Objectives: The hospital has high risk and high return characteristics of the industry, so the survival and influence of life and health environmental uncertainty on the relationship between medical financial flexibility and internal control in hospital is studied.

Methods: This study takes 100 Chinese listed hospitals and A-share of main medical market from 2008 to 2017 as the research objects. The loss data are excluded to obtain the 4500 samples data of the 100 Chinese listed hospitals in 10years. The internal control data of the listed hospitals are derived from the DIB internal control and risk management database, and the other data comes from the CSMAR database and the RESET database.

Results: The results show that internal control quality in hospital can rise if the life and health financial flexibility increases and that life and health environmental uncertainty restrains the positive correlation between medical financial flexibility and quality of internal control in hospital.

Conclusions: The research enriches and expands the literature on life and health financial flexibility and quality of internal control in hospital, which demonstrates certain guiding significance to the practice of internal control in hospital.

Acknowledgements: Supported by a project grant from Ministry of Education in China Liberal arts and Social Sciences fund (Grand No. 13YJA630085).

Accounting Conservatism and Debt Financing Cost of Medical Care Based on Internal Control Quality About Healthy in Medical Industry

Shi J., Wang A.Q.

School of Management, Jilin University, Changchun, China

Objectives: In order to obtain more effectively ensure on the financial statements of medical industry, the relationship between accounting conservatism and debt financing cost of medical care is studied based on internal control quality about healthy in medical industry.

Methods: This paper uses 2006–2013 A-shares in medical industry as samples, and developed empirical study on the effect of internal control quality about healthy and accounting conservatism on debt financing by establishing the test multiple regression model.

Results: The empirical results shows accounting conservatism and debt financing costs of medical care are negatively related; internal control quality about healthy and debt financing costs of medical care are negatively related by SPSS22.0 and STATA12.0 displaying the regression results. The patient's medical insurance cost planning curve is smooth based on Basu model.

Conclusions: The related practical results of these factors have promoted the healthy development of the medical industry, improve the implementation of medical insurance and provided the effective guarantee of health care.

A Study on the Treatment of the Waist Injury in the Javelin Movement

Xu Z.J.

Department of Physical Education, Changchun Institute of Technology, Changchun, China

Objectives: The purpose is to discuss the causes and treatment of the waist injury of javelin throwers.

Methods: The causes and treatment methods of the waist injury of 250 javelin throwers are analyzed comprehensively. Physiotherapy and drug therapy are comprehensively used. Manipulation therapy is mainly used in the late stage, mainly including massage, rolling, finger kneading, lumbar oblique pulling, physical therapy, water therapy, active rest and training differential treatment methods. For gradually serious waist injury, the manipulative therapy can be adopted after 36–48h of injury. Relaxing muscles and tendons and dredging collateral, and stopping bleeding and removing stasis are the basic criteria for the treatment.

Results: In the immediately serious waist injury, lumbar muscle overload injury and technical error loss are the common types of injury, and wind cold symptom is the most common type of gradually serious lumbar injury. The manipulation was used to treat the immediately serious and gradually serious waist injuries. After a variety of treatments, more than 80% of the patients had obviously alleviated the disease, and the rest of the patients had some relief.

Conclusions: The comprehensive use of various treatment methods can effectively alleviate the waist injuries, and achieve the purpose of activating blood and removing blood stasis.

A Optimization Method of Overall Plan for Land Utilization and the Effect of Recovery Rate of the Patients

Yuan X.¹, Xie D.T.¹, Cao W.²

¹College of Resource and Environmental, South West University, Chongqing, China; ²Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou, China

Objectives: In order to ensure the scientific implementation of objectives and tasks of overall plan for land utilization and locate geographical distribution of rehabilitation centers, a optimization method of overall plan for land utilization is studied and the effect of recovery rate of the patient is analysed.

Methods: Five hundred national rehabilitation centers were selected as the research object, and this paper applies BP neural network to explore the implicit relationship between the overall plan for land utilization and recovery rate of patients, and applies ant colony algorithm into the parameter optimization of BP algorithm, which obtain evaluation optimization model.

Results: The results show that overall plan for land utilization and locate geographical distribution of rehabilitation centers directly affect the recovery rate of the patient through the curve of the relationship between utilization rate and recovery rate.

Conclusions: The proposed method can improve the scientificity, adaptability and feasibility of overall plan for land utilization, and give full play to the regulation and guidance of land planning, which improve the treatment environment of rehabilitative patients, increase the coverage rate of rehabilitation centers, and provide more rehabilitation sites for rehabilitation patients.

The Role and Influence of Environmental Image, Recreational Satisfaction, and Perceived Crowding for Tourists’ Physical and Mental Health

Zhang Y.G.^1,2, Huang G.Q.², Cheng J.J.³, Yu X.Y.³

¹Academy of Economics and Management, Huangshan University, Huangshan, China; ²Faculty of International Tourism and Management, City University of Macau, Macau, China; ³School of Tourism, Huangshan University, Huangshan, China

Objectives: Contacting with nature works in enhancing well-being and arising greater restorative physical and mental health from experiences in nature, especially when tourists with disease can fit in the nature environment.

Methods: This study is proposing a model with environmental image as antecedent, recreational satisfaction as a mediator, perceived crowding as a moderator, and loyalty as an outcome. Collect 412 volunteers with disease from the hospital as the experimental group and lead them to the ancient village, and observe their physiology and emotion changes and adopt SPSS 21.0 and AMOS 21.0 to further analyze the data and test the proposed model.

Results: The results indicate that the environmental image tourists with disease perceived have statistically positively influenced the recreational satisfaction (p<0.05) and loyalty (p<0.05). The tourists’ crowding perceptions can help to moderate these relationships and their physical and mental health.

Conclusions: The physical and mental health, restorative experiences, and individual environmental action of tourists with disease are constructed by the model, which plays a vital role in pursuing well-being and physical and mental health.

Acknowledgements: Supported by a project grant from Training Program for Young Professionals of Tourism Industry in Anhui Province (Grand No. AHLYZJ201604); National Natural Science Foundation of China (Grand No. 41571140); 2017 the Key Program in the Youth Elite Support Plan in Universities of Anhui Province (Grand No. gxyq2017076, gxyqZD2017081); Key Research Project of Humanities and Social Sciences of Anhui Provincial Department of Education (Grand No. SK2015A527, SK2016A0875).

Research on Computer Recognition Based on the Shape Features of Medical Images

Tan Y.J., Wang Q., Qin J.

College of Computer Science and Technology, Zhoukou Normal University, Zhoukou, China

Objectives: The purpose is to study the computer recognition application based on the shape features of medical image.

Methods: The liver CT image contour image is selected, the analysis method that uses the shape feature quantities of the microscopic surface unevenness of the liver contour to characterize the liver feature is used, and the scheme that uses SVM algorithm classifier to obtain the shape feature quantities of the liver CT image is adopted.

Results: In the clinical case of image recognition based on this method, 5 sets of blurred images are successfully displayed. The classification diagnosis weight distribution of different feature quantities and the overall classification effect of the texture feature quantity and shape feature quantity are obtained.

Conclusions: The classification diagnosis effect of liver fibrosis of the shape feature quantities is better than the texture feature quantities, and the accuracy of diagnosis is improved.

Acknowledgements: Supported by a project grant from National Natural Science Fund (Grand No. U1504613); Soft Science Research of Henan Intellectual Property Office (Grand No. 20170106036); Henan University Scientific and Technological Innovation Team (Grand No. 17IRTSTHN009)

An Error Correction Method of Medical Instrument System Based on Computer Software and Algorithm Processing

Xie W.D.

Department of Electronic and Information Technology, Jiangmen Polytechnic, Jiangmen, China

Objectives: In order to reduce the systematic error and precise measurement data of medical instrument, a error correction method of medical instrument system based on computer software and algorithm is studied to meet the accuracy of medical instrument measurement.

Methods: Ten groups of data obtained by the medical instruments within 30days were randomly selected to establish the error model. First, a set of discrete data that reflected the measured amount was obtained by measurement, and then the approximate mathematical model that reflected the changes of the measured amount was established by using these discrete data. Then the computer platform was used and the non-equidistant node piecewise linear method was also used for correction.

Results: After the 10 groups of measurement data after the error correction of the medical instrument system are compared with the random data, we can see that the measurement accuracy of the system is improved by 38%, and the approximation degree of the measurement curve is increased by 11%. The data reflect the objective condition of the patient's physical signs more truly.

Conclusions: The clinical practice proves that the computer program software method can weaken the influence of the measurement error, improve the measurement accuracy and reliability, and meet the needs of different medical instrument systems.

Study of Novel Fractional Order Chaotic Image Encryption Algorithm in Medical Image Processing

Guo H.¹, He G.M.², Li L.³

¹Guangxi Colleges and Universities Key Laboratory of Image Processing and Intelligent Information System, Wuzhou University, Wuzhou, China; ²School of Information and Electronic Engineering, Wuzhou University, Wuzhou, China; ³College of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan, China

Objectives: The purpose is to study the application of image encryption algorithm in medical image processing and achieve higher security in medical image processing.

Methods: Six hundred medical images were selected as experimental objects. Through analyzing the method that the block cipher and the chaotic mapping principle construct the chaotic block cipher, the DES algorithm based on two-dimensional chaotic mapping is designed, and then the two-dimensional mapping and the algorithm are combined to dynamically change the round key.

Results: The improved algorithm is applied to medical image encryption in the clinical process of the hospital. Through the clinical application evaluation of medical images, 82.5% of the experimental images obtain the protection of the demand and 88.8% of the experimental images acquire effective encryption mode, which effectively improves the security.

Conclusions: The medical image data is effectively protected in the transmission. On the premise of ensuring the security of the algorithm, the efficiency of medical execution is improved and the practicability is enhanced.

Acknowledgements: Supported by a project grant from National Natural Science Foundation (Grand No. 61562074 & 61502343); Guangxi Natural Science Foundation (Grand No. 2015GXNSFAA139295); Wuzhou Scientific Research and Technology Development Project (Grand No. 2014B01030).

Application Research of BM3D Algorithm to Remove the Medical Image Noise

Wang L.Y.¹, Shang J.K.²

¹School of Mathematics and Information Science, Langfang Teachers University, Langfang, China; ²Department of Firepower Platform, Army Academy of Artillery and Air Defense, Nanjing, China

Objectives: The noise interference can impede the acquisition of useful information from medical images and affect the diagnosis of diseases, or even lead to misdiagnosis, so in this paper, a method of removing medical image noise is studied.

Methods: The medical image is divided into several equal area blocks. According to the similarity between image blocks, two-dimensional image blocks with similar structure are combined to form a three-dimensional array. Then, the joint filtering method is used to process these three-dimensional arrays. Finally, by inverse transformation, the processed results are returned to the original image to get the de-noised image.

Results: The proposed BM3D algorithm is applied to electrocardiogram ECG analysis, electroencephalogram EEG analysis, electroretinogram ERG analysis, X-ray film processing, CT image reconstruction, cell and chromosome microscopic image processing, blood flow velocity measurement, and biological signal chaos measurement. The result is that the effect of noise removal is good.

Conclusions: Clinical practice proves that this method reduces or removes the noise in medical images, enhances the quality of images, and improves the accuracy of disease diagnosis, which has certain research value.

Study on Gymnastic Training Methods and Sports Injury Mechanism

Li H.Y.

PE Teacher's Office, Sichuan Technology and Business University, Chengdu, China

Objectives: The purpose is to discuss the methods of gymnastics training and the mechanism of sports injury.

Methods: Physical therapy and functional training are used to study gymnastic training and injury mechanism. The injuries of 50 gymnasts who were treated from October 2016 to November 2017 were investigated. The 50 gymnasts were randomly divided into the observation group and the control group. The observation group was treated with physical therapy and functional training, and the control group was treated and trained with conventional methods. The effects of the treatment and training of the two groups were compared.

Results: All two groups of athletes are cured. Compared with before treatment, the development of special sports potential and the strength of special skills and tactics of the athletes in the observation group are significantly improved, and the difference is significant. Compared with the control group, the difference is also significant.

Conclusions: Physical therapy and functional training can not only prevent sports injuries, but also effectively develop athletes’ potential and enhance their tactical strength, which is worthy of clinical promotion and application.

Acknowledgements: Supported by a project grant from Sichuan Technology and Business University (CGSKY-14).

Study on Electrochemical Impedance Spectroscopy in the Cement Hydration Process of Concrete Mixed with Fly Ash or Slag for Human Health

Jiang F.J.^1,2, Gong J.X.¹, Gao S.F.¹, Zhang W.¹

¹Faculty of Infrastructure Engineering, Dalian University of Technology, Dalian, China²College of Information Engineering, Dalian Ocean University Dalian, China

Objectives: When producing traditional cement, a large amount of harmful gas is released, such as carbon dioxide and so on, which has great harm to the living environment and physical health of human beings. Study a method to effectively reduce the harm to environment and human health in the process of cement production.

Methods: The cement hydration of concrete mixed with fly ash or slag has been studied by employing the electrochemical impedance spectroscopy method. The influence of the mineral admixture on the electrochemical impedance parameters in the concrete cement hydration process is analyzed.

Results: The results show that the variation trend of concrete electrochemical impedance spectroscopy is same with different dosage of fly ash or slag. The impedance parameters reduced and the total porosity of the concrete increased with the raise of mineral admixtures content incorporated in concrete and the structure of concrete becomes loose. The more dosage of mineral admixture the concrete has, the more significant effect is.

Conclusions: The mineral admixture can reduce the amount of cement and emissions of harmful gases, which is beneficial to human health.

Acknowledgements: Supported by a project grant from 973 Project (No. 2015CB057703).

Study on Visual Interaction and Cognitive Experience of Food Design on the Background of New Media Communication based on Eye-tracking Technology Testing

Zong L.S.¹, Zhou M.², Mi N.¹

¹Division of Academic Affairs, Xihua University, Chengdu, China; ²College of Fine Art and Design, Xihua University, Chengdu, China

Objectives: On the background of new media time, the food-related internet platforms have changed from PC to mobile and all-media, while the visual design of them also occurred in the potential changes, which provides the food design with a new opportunity for development and also gives a unique cultural experience of food culture.

Methods: The research group took 16 people who had direct APP-products experience as test users, carried on the experiment test by eye trackers and interviewed them, then took experiment test and the design analysis to the present popular food application product APP, trying to draw the visual characteristics of the food pictures on the mobile side.

Results: This paper analyzes and presents the new trend of the use of food design in the new media communication. The testing results discover interesting phenomenon is that the visual elements with sense mapping are more important than food photography itself. And to users, the food photography images are more attractive than texts.

Conclusions: Food design has been influenced by scene, color, synaesthesia and other factors, and improving the relevant factors will help improve food design in the new media visual experience. The new media lifestyle based on palm reading habit has changed cognitive visual experience.

Acknowledgements: Supported by a project grant from general project of Sichuan Province Industrial Design Research Center (Grant No. GYSJ17-003)

Application of Linux in the Safety Management of Hospital Database

Lv J.Y.

College of Computer and Information Engineering, Henan University of Economics and Law, Zhengzhou, China

Objectives: The purpose is to study the application of Linux in the safety management of hospital database.

Methods: According to the current situation of the safety management of hospital database, a set of system management tools is developed and designed to manage the hospital server. It adopts the architecture design that combines C/S and B/S, uses WBEM distributed management technology, takes the Linux server as the development platform, and designs the management software with rich graphical interface.

Results: It makes the hospital database management system more perfect, ensures the normal operation of the hospital data safety library, and eliminates the necessary security risks.

Conclusions: It can be put into use in large hospitals and small and medium hospitals to improve the comprehensive strength and social benefits of the hospital.

Analysis of the Influence of Consumption Environment Psychology on Rural Health Care Consumption Behavior

Chen J.Y.¹, Lin S.J.²

¹Business School, Sichuan Agricultural University, Dujiangyan, China; ²College of Tourism, Sichuan Agricultural University, Dujiangyan, China

Objectives: The factors affecting the rural medical consumption are explored based on the consumption environment psychology, so as to solve the problem of medical consumption distribution structure optimization.

Methods: This paper collects basic data through questionnaire survey, uses the comprehensive analysis method to sum up the influencing factors of the consumption environment psychology to the rural medical consumption, and finds out the influencing factors with larger weight. Then the genetic algorithm is used to optimize the data and then train the data through neural network.

Results: The simulation results show that the main factors are obtained under the comprehensive evaluation method. It is concluded that age, living environment and income level have great influence on rural physiotherapy consumption, which are the influencing factors with larger weight. The corresponding measures are formulated according to the influencing factors. A variety of incentive methods are used to stimulate consumption psychology, and the effects of consumption environment psychology on rural health care consumption behavior are evaluated objectively.

Conclusions: In the process of urbanization construction, we need to help the countryside build a good medical consumption environment by improving the basic medical system, correctly guide people to consume, and optimize the consumption distribution structure from the side, so as to promote the sound development of the medical industry.

Acknowledgements: Supported by a project grant from Sichuan Social Science Research Program (No. SC16C022).

Research on the Traceability System of Agricultural Products in Health Based on Cloud Computing

Liu F.

NetWork & Information Center, Yulin University, Yulin, China

Objectives: In order to bring sustainable health to human beings, study a traceability system of agricultural products in health based on cloud computing.

Methods: The cloud computing technology with high storage and high load processing performance is used to improve the response speed and access performance of the access, an agricultural product safety traceability system based on private cloud is designed, the Hill-Climbing search algorithm is used to optimize the cloud platform configuration and the MapReduce is used to carry out the parallel computing for big data, so as to study the relevance factors of the safety of agricultural products and health degree through the agricultural product traceability system.

Results: The practice proves that the performance of agricultural product safety traceability system on private cloud is improved, and all links in the system are effectively monitored for safety, so as to provide help for human health.

Conclusions: By comparing the experiments before and after the system migrates to the private cloud, we can know that the performance of the system is greatly improved after migrating to private clouds, so as to improve the system access response speed and establish a stable agricultural product safety traceability system.

Acknowledgements: Supported by a project grant from Key Technological Project on Agricultural Innovation of Shaanxi Science and Technology Department (No. 2016NY-134); National Natural Science Foundation of China (No. 11641002).

Research on Trading Platform of Agricultural Products in Health Based on Cloud Computing

Liu F.

NetWork & Information Center, Yulin University, Yulin, China

Objectives: The purpose is to apply the cloud computing technology to the agricultural information industry to provide the basis for the co-construction and sharing of the information resources of agricultural products trading, provide a reference for future agricultural departments to formulate relevant policies, find the relationship between the development and health of agricultural products trading platform, and provide the corresponding countermeasures.

Methods: The idea of platform construction is combed, and the mode of building the platform is designed. Combined with the current situation, problems and functions of cloud computing agricultural products trading platform, this paper analyzes the problems existing in the process of building cloud computing agricultural products trading platform, and puts forward suggestions for safeguard measures.

Results: The unified data standard and physical storage environment are used to simplify the co-construction and sharing of product transaction service information resources, which improves the efficiency of agricultural product trading, and finds a new basis for promoting the sale of healthy agricultural products.

Conclusions: The cloud computing platform provides a guarantee for the development of the agricultural products trading service information, and sets up a good platform for providing healthy agricultural products.

Acknowledgements: Supported by a project grant from Key Technological Project on Agricultural Innovation of Shaanxi Science and Technology Department (No. 2016NY-134); National Natural Science Foundation of China (No. 11641002).

The Influence of Green Value Stream Mapping Integration for Human Health on the Environment Performance Based on the Carbon Efficiency Analysis Model of Lean Production System

Zhu X.Y.^1,2, Zhang H.¹, Jiang Z.G.¹, Jia H.Q.²

¹School of Machinery & Automation, Wuhan University of Science and Technology, Wuhan, China; ²School of Safety & Environmental Engineering, Hunan Institute of Technology, Hengyang, China

Objectives: The increasing in carbon emissions are the result of global warming, greenhouse effects, and extreme weather. It is also a direct hazard to people's health and quality of life. Increasing concern about the environment has led to a more environmentally friendly approach to improve the production process, which has led to greater pollution prevention by reducing waste and increasing carbon efficiency. The key of achieving low carbon manufacturing is to research and reduce carbon emission of production system effectively.

Methods: In view of this, combining lean thinking with low carbon manufacturing, Green Value Stream Mapping integrating time flow, energy flow, material flow, transportation flow and carbon emission flow was proposed which described non-value carbon emission and value carbon emission. And a mathematical model using carbon efficiency as evaluation indicator was established.

Results: To improve carbon efficiency, carbon emission of the seven wastes was analyzed and calculated, meanwhile improvements of eliminating the seven wastes were proposed. The feasibility of the model is analyzed and verified by taking the manufacturing process of a metal stamping part as an example.

Conclusions: It can be seen that the way of low carbon production can help enterprises to reduce energy consumption and production costs, save energy consumption, protect the ecological environment, and promote the improvement of human survival environment and people's health.

Acknowledgements: Supported by a project grant from National Natural Science Foundation of China (No. 51775392); the Education Department of Hunan Province (No. 17C0454); the Hengyang Science and Technology Board (No. 2017KJ255) and the Inquiry Learning and Innovative Experiment Project of College Students of Hunan Institute of Technology.

Progress and Prospect of the Application of Big Data in Agricultural Ecological Environment and Human Health

Wang X.G.

School of Business, Yulin Normal University, Yulin, China

Objectives: The purpose is to study the progress and prospect of the application of big data in agricultural ecological environment and human health.

Methods: Based on the development of agricultural environmental resources association and human health, the current situation of agricultural ecological environment monitoring and human health development is summarized, and a data model for agricultural ecological environment and human health is established.

Results: The application of big data analysis in agricultural ecological environment protection and human health is prospected. It is pointed out that the decision-making in the era of big data will be more and more supported by data and analysis. The association analysis should be carried out for different information by using big data, and the causality and inevitability between data should be found.

Conclusions: It provides a guarantee for the scientific and technological decision-making of agricultural ecological environment protection and the healthy development of human beings.

Acknowledgements: Supported by a project grant from National Social Science Foundation of China (No. 17BKS068); The Key Research Project of the Research Center of Cultural Construction and Social Governance in Ethnic Minority Areas of Yulin Normal University in 2017 (No. 2017YJJD00011).

Research on the Application of Big Data in the Evaluation of Forest Ecosystem Service Function and Human Health Development

Wang X.G.

School of Business, Yulin Normal University, Yulin, China

Objectives: The purpose is to study the application of big data in the evaluation of forest ecosystem service function and human health development.

Methods: In this paper, taking the big data analysis method as the goal, the progress of the evaluation of the forest ecosystem service function and the challenges facing human health development are analyzed, the big data observation system based on forest observation station network and remote sensing technology is discussed, the dimension analysis, spatial analysis and attribute analysis methods of the forest ecosystem service function evaluation and human health development data are expounded, so as to propose a dimension for the evaluation of forest ecosystem service function and the application of human health.

Results: The future direction of the study of the evaluation of forest ecosystem service function in the big data age is summarized, and the measures for the quality of human health are improved.

Conclusions: The construction of the big data observation system of the forest ecology can effectively solve the problem of regional heterogeneity, which has a reference value for the healthy development of human beings.

Acknowledgements: Supported by a project grant from Humanities and Social Sciences Projects of the Ministry of Education (No. 16YJA630072); The Key Research Project of the Research Center of Cultural Construction and Social Governance in Ethnic Minority Areas of Yulin Normal University in 2017 (No. 2017YJJD00011); Scientific Research Projects of Yulin Normal University (No. 2017YJKY03).

Analysis of the Cause of Sports Injury of Basketball Centre Forward

Yin L.

College of Physical Education, Wuhan Sports University, Wuhan, China

Objectives: The purpose is to analyze the cause of sports injury of basketball centre forward.

Methods: Literature, expert interview, questionnaire survey, logical analysis and mathematical statistics methods are used to investigate the current situation of sports injury of basketball centre forward. The incidence rate of sports injury, the time of injury, the part of injury and the nature and characteristics of injury are mastered.

Results: The sports injury of the men's basketball centre forward is very serious. The main parts are the ankle joint, the waist, the finger joint, and the knee joint. The reasons of the sports injury of men's basketball centre forward are training with injuries, excessive local burden, inadequate preparation and the violation of the rules.

Conclusions: The athletes’ health files should be set up, the conditions should be provided for targeted treatment and scientific research, and the theoretical basis should be provided for improving the quality of the reserve force of professional basketball in China and the sport life of athletes.

Discussion on the Effect of Functional Strength Training on the Prevention of Aerobics Injury

Qiu T.

College of Physical Education, South-Central University for Nationalities, Wuhan, China

Objectives: The purpose is to discuss the effect of functional strength training on the prevention of aerobics injury.

Methods: From the perspective of preventing sports injury, aiming at the characteristics of aerobics, taking aerobics athletes as the experimental subjects, the effect of physical function strength training on the prevention of aerobics injury is studied.

Results: Through the functional strength training, athletes’ strength and quality level is not only improved, but also the athletes’ ability of control and stability under unstable conditions is also improved, which has a significant effect on improving the ability of injury prevention in aerobics.

Conclusions: Through the study, the general coaches and athletes have a deep understanding of the functional strength training, and for vulnerable parts of the body, the targeted measures should be carried out to prevent injury and the training should be enhanced, which is of great practical significance for the aerobics athletes to improve their competitive performance.

Research on the Effect of Physical Fitness Training of Basketball Players on Prevention of Injury

Jiang H.

College of Physical Education, Wuhan Sports University, Wuhan, China

Objectives: The purpose is to study the effect of physical fitness training of basketball players on prevention of injury.

Methods: Combined with the system theory, the physical fitness system of the high level basketball players is analyzed, and the structure and characteristics are revealed. The relevant information is analyzed and the results of previous research are summarized, and on this basis, the scientific basis and basic rules of the special physical fitness training of basketball players are discussed.

Results: Physical fitness training is the basis of other training. It can promote good health, can fully develop physical quality, and can ensure that the organism can adapt to the needs of heavy load training and competition. It is also conducive to mastering complicated and advanced technologies and tactics, creating excellent results and prolonging the sport life.

Conclusions: Understanding the basic theory of physical ability and physical fitness training is of certain significance for the study of the prevention of injury in the physical fitness training of Chinese basketball players.

Optimization and Modeling of Hospital Queuing Network System Based on Queuing Theory and Simulated Annealing Algorithm

Ji X.Y., Nong J.

Guangxi Colleges and Universities Key Laboratory of Professional Software Technology, Wuzhou University, WuZhou, China

Objectives: The crowded queues of a large number of patients in hospitals have become the main obstacle for hospital departments to improve the quality of service and enhance the image of hospitals. Therefore, the queuing network system of hospitals is optimized and modeled.

Methods: Based on the concrete data of queuing in hospitals, queuing rules and service rules are constructed by queuing theory. Combined with the advantages of simple description, flexible use, wide application and efficient operation, the queuing network system of hospitals is optimized and modeled.

Results: Through the implementation of the system, the queuing management system of hospitals can solve the queuing problems of the patients awaiting diagnosis in the consulting room after the registration in the hospital, and the queuing problems in various links, such as charge, pharmacy, inspection, testing departments and so on. The queuing system has a flexible configuration function of the triage queuing one time and the awaiting diagnosis queuing two times, which can be configured flexibly according to the actual conditions of the diagnosis area.

Conclusions: This system can improve the service order and quality of hospital waiting area, calm the hospital environment, reduce the artificial triage pressure of medical staff, make the awaiting diagnosis arrangement scientific and reasonable, and improve the work efficiency.

Acknowledgements: Supported by a project grant from National Natural Science Foundation of China (No. 61502343).

Research on the Extraction of Classification Characteristics of Text Cases of Hospital Based on Deep Belief Network

Nong J., Ji X.Y.

Guangxi Colleges and Universities Key Laboratory of Professional Software Technology, Wuzhou University, WuZhou, China

Objectives: In this paper, the deep belief network is used to study the extraction method of text case classification characteristics, and to solve the difficult problem that medical text cases are difficult to classify.

Methods: The cases in 100 hospitals are collected and sorted out. Through the learning ability of the deep belief network, the low dimensional characteristics that the low dimensional height can be distinguished are extracted from the primitive characters of high dimension. The regression classifier is used to classify the extracted text case characteristics.

Results: The simulation results show that the classification accuracy and specificity of the algorithm are strong. The practice results show that this method can get enough amount of information of case documents, and can quickly train, so that the classification of cases in 100 hospitals can be effectively improved. The effective classification rate of the case month is up to 93.65%, which provides an effective management plan for hospital document management.

Conclusions: Compared with the traditional method, the deep belief network method achieves the excellent effect of the extraction of the classification characteristics of text cases, and provides the objective auxiliary case information to the doctor in time, which has a certain practical value.

Acknowledgements: Supported by a project grant from National Natural Science Foundation of China (Grant No. 61502343), National Social Science Foundation of China (Grant No. 15XMZ069), Natural Science Foundation for Young Scholars of Guangxi (Grant No. 2015GXNSFBA139262), basic ability improvement project of young college teachers of Guangxi (Grant No. KY2016LX366).

Health Degree Analysis of Special Transformer for Medical Equipment by Photoacoustic Spectroscopy Based on Data Mining

Niu G.C.^1,2, Hu Z.¹, Hu D.M.²

¹College of Electronic Information Engineering, Changchun University Science and Technology, Changchun, China; ²College of Electrical and Information Engineering, Beihua University, Jilin, China

Objectives: In order to ensure the stable and reliable operation of medical equipment, the health degree of the special transformer of medical equipment was analyzed by photoacoustic spectroscopy.

Methods: The various gases produced when the transformer fault is detected by using the photoacoustic spectroscopy are studied. The cross compound matter element is set up by the type of transformer fault and the evaluation index of the fault gas, the joint weight of the evaluation index is determined by the analytic hierarchy process and the maximum entropy method, and the matter element-maximum information entropy is used to carry out the quantitative calculation analysis for the health degree of the transformer.

Results: Two types of support vector machines and three parameter self-optimizing methods are used to build the prediction model of the transformer health. Through the machine learning for transformer's history health degree and the prediction of future operation of the transformer, the calculation results and prediction results of health degree have achieved good results.

Conclusions: This method is of great value to guide the use and maintenance of special transformer for medical equipment and ensures the stable and reliable operation of medical equipment.

Acknowledgements: Supported by a project grant from National Natural Science Foundation of China (Grant No. 91338116); The National Key Basic Research and Development Program (973 Plan)(Grant No. 613225).

Influence of Combined Application of Nitrogen, Phosphorus and Potassium Fertilizer on Yield of Chinese Herbal Medicine Material Isatis Indigotica Fort. Root

Cai Z.P.^1,2, Wang H.X.¹, Wang G.X.^1,2, Du T.³, Jin L.³, Wang E.J.⁴

¹Chinese Herbal Medicine Research Institute of Gansu Academy of Agricultural Sciences, Gansu Chinese Herbal Medicine Germplasm Improvement and Quality Control Engineering Lab, Lanzhou, China; ²Gansu Chinese Herbal Medicine Industry System, Lanzhou, China; ³College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, China; ⁴College of Agriculture and Biology, Hexi University, Zhangye, China

Objectives: In order to provide reference for rational application of fertilizer for Chinese herbal medicine material isatis indigotica Fort. Root.

Methods: By “3414” fertilizer experiments, the yield of isatis indigotica Fort. were determined in each fertilizer group; the maximum yield and the relative amount of fertilizer were obtained under the Excel 2010, SPSS 17. 0 systems.

Results: Fertilization treatment significantly influenced the yield of isatis root, and the yield after N2P2K1 was applied was maximally 19654.08kg/hm², increasing by 59.68% than the yield when the plants were not fertilized. Within fertilization scope, applying 1kg Phosphorus and Potassium fertilizer to each hectare can increase 5.14kg and 46.54kg yield of isatis root respectively.

Conclusions: The recommended application rates for N, P2O5, K2O are respectively 82.78kg/hm², 106.51kg/hm², 39.13kg/hm², then the isatis root yield reached 16774.11kg/hm².

Acknowledgements: Supported by a project grant from Special Scientific Innovation Program of Gansu Academy of Agricultural Sciences (Grant No. 2013GAAS03-02, 2017GAAS29); Part of 2015 Commonweal Special Scientific Research Program of Research on Quality Guarantee System of TCM Decoction Pieces (1) (Grant No. 201507002); Sub-Program for the Program of Local Scientific Innovation Platform under Guidance of Central Finance (Grant No. 2016-A-02); Lanzhou Program of Scientific Plan (Grant No. 2014-1-203).

Research on the Influencing Factors of the Satisfaction Degree of the Employees of the Service for the Aged Participating in the Intelligent Medical Work

Fei J.B., Zhang W.P.

Ningbo Dahongying University, Ningbo, China

Objectives: The purpose is to study the influencing factors of the satisfaction degree of the employees of the service for the aged participating in the intelligent medical work, and put forward reasonable suggestions for the protection of human health cause.

Methods: Combined with the connotation of the satisfaction degree of the employees of the service for the aged participating in the intelligent medical work, comprehensively considering the characteristics of various groups, the scale of job satisfaction of the employees of the service for the aged is compiled. The scale consists of 2 first-level indexes: exogenous satisfaction degree and endogenous satisfaction degree, 6 second-level indexes, 12 third-level indexes and 30 fourth-level indexes. Finally, 500 questionnaires were issued and 500 questionnaires were recovered, and the recovery rate was 100%. The effective rate of the questionnaire was 91.4%.

Results: According to the empirical findings and correlation analysis, aiming at the current situation of satisfaction degree and group characteristics of different groups such as grass-roots caregivers, professionals, managers and so on, we seek effective ways to improve satisfaction degree from two aspects: external factors and related pension institutions themselves.

Conclusions: The research results can effectively and flexibility introduce professional and technical personnel of medical institutions by regions, and integrate all resources to enhance the social status of the talents of the service for the aged.

Acknowledgements: Supported by a project grant from Zhejiang Civil Affairs Policy Theory Research (Grant No. ZMZC201714).

Synthesis, Characterization and Catalytic Activity of Low-Medium Temperature Fe-Ce-Ni/TiO2 four-metal Oxide SCR Catalyst

Zhang D.¹, Li Y.F.², Zhang X.¹, Meng X.C.¹, Sun Y.¹, Sun W.Y.^1,3

¹State Grid JiLin Electric Power Research Institute, Changchun 130021, China; ²Environmental Protection Department of JiLin Province, Changchun 130033, China; ³ChangChun University of Chinese Medicine, Changchun 130117, China

Aims: The preparation of low-medium temperature selective catalytic (Selective catalytic reduction, SCR) flue gas denitration catalyst, with high denitrification efficiency, low cost and anti poisoning ability are of high research value and practical application value for coal fired power plant. It also possesses great importance to the protection of atmospheric environment.

Methods: Via coprecipitation method, with TiO2 powder as effective carrier, three water-soluble salts Fe2(SO4)3, CeCl2 and NiCl2 as reactive components, a low-medium temperature SCR denitration catalyst Fe-Ce-Ni/TiO2 has been prepared.

Results: A Fe-Ce-Ni/TiO2 catalyst is successfully prepared. In the low-medium wide temperature range (150–300°C). It exhibits well denitrification efficiency under the toxic atmosphere of H2O and SO2.

Conclusions: A four-metal oxide catalyst Fe-Ce-Ni/TiO2 has been successful fabricated. Under the continuous poisoning of H2O and SO2, the prepared SCR catalyst shows well and stable denitrification performance.

Application of Double Rotor Speed Regulating Wind Power Generation System in Solving Energy and Environment Problems

Li Y.N., Yang P., Wang H.J.

College of Control Science and Engineering of Hebei University of Technology, Tianjin, China

Objectives: Wind power has become an important object of R&D around the world as an effective measure to solve the current energy crisis and environmental contamination. Nevertheless, DFIG and PMSG have the disadvantages of poor grid connected capacity when the wind turbines becoming large scale. Therefore, the new concept of speed regulating wind turbine is presented.

Methods: The changing wind speed is regulated to a constant speed by the speed regulating device between the wind turbine and the generator, so the synchronous is driven to generate normal frequency electricity. The double rotor speed regulating wind power generation system has the ability of speed regulation and power generation at the same time in a certain period of time and reduces the capacity of generator and converter as a new type of driving chain of speed regulating wind turbine.

Results: The double rotor speed regulating wind power generation system can realize the capability of active power overload and reactive power support of the power grid since the synchronous generator is directly connected with the power grid at the end of the driving chain. Furthermore, the variable speed constant frequency operation of the system in the whole wind speed range is guaranteed by multimode operating state under different wind speeds so as to capture the maximum wind power. In addition, the damage of the synchronous generator caused by wind speed fluctuation is reduced as the double rotor speed regulating generator connecting the gearbox and the synchronous generator, so the reliability of the system is improved.

Conclusions: The double rotor speed regulating wind power generation system has a wide application prospect to alleviate the energy crisis and respond to the worsening natural environment.

Spatio-temporal Variability in Antarctic Snowmelt Based on Microwave Radiometer Data (1978–2017)

Wang X.D.¹, Wu Zh.K.¹, Li B.¹, Yan J.P.²

¹College of Information Science and Engineering, Henan University of Technology, Zhengzhou, Henan 450001, China; ²Third Institute of Oceanography, State Oceanic Administration, Xiamei, Fujian 361005, China

Background: Global climate and environmental variability is an important issue in today's world. Antarctica is a key region in this regard with the Antarctic ice and snow changes being one of the most important factors affecting global climate and environmental change. The spaceborne microwave radiometers can be used macroscopically, rapidly, objectively and effectively to monitor and assess the Antarctic snowmelt variability. In the paper, we obtained the average snowmelt onset date, end date, and duration as well as the annual variability and the seasonal variability, for the 38-year period from 1978 to 2017, based on the improved wavelet transform method.

Methods: The paper focuses on the snowmelt detection based on improved wavelet transform. The difference between the improved method and the original method is to determine the optimal classification threshold of dry snow and wet snow using the generalized Gauss model rather than the double Gauss model. By using the multi-scale wavelet decomposition with the measured temperature data from the long time series of microwave radiometer brightness temperature data, we obtain temporal resolution of one day.

Results: The spatial distribution of snowmelt areas shows that most are located on the edges of Antarctic ice shelves. Snowmelt areas are affected by land cover type, surface elevation, and geographic location. The temporal distribution of snowmelt areas shows that the Antarctic snowmelt changes systematically over time. The total snowmelt area is largest in 2012 at 1,611,250km² and smallest in 1999 at 565,000km². There are the roughly 5-year periodic variations in the melt intensity, which shows that the Antarctic snowmelt will adjust to climate change (negative feedback on climate change). In addition, the Antarctic snowmelt varies with the seasons; it is particularly acute in summer, with peak melt in December and January and low melt in March.

Conclusion: The proposed improved wavelet transform is feasible for snowmelt detection. The spatio-temporal variability in Antarctic snowmelt is regular based on microwave radiometer data (1978–2017).

Acknowledgments: The National Science Foundation of China; Foundation Number: 41606209. The Fundamental Research Funds for the Henan Provincial Colleges and Universities; Foundation Number: 2015QNJH16. The Fund of Key Laboratory of Global Change and Marine-Atmospheric Chemistry; Foundation Number: GCMAC1605.

[Correction added on 6 April 2018, after first online publication: The names of the authors have been corrected in this version.]

The Expression of Drp1 and Mfn1/2 in Hippocampus of Rats in Mitochondrion After Exhaustive Exercise

Wang L., Deng W.Q., Lv Y.Y., Wang D.H., Chen K.

Department of Sports Medicine, Chengdu Sport Institute, Chengdu, China

Objectives: Mitochondrion can change the morphology in order to adapt to different stimulation and process, thus there is a close relationship between the morphology and the function of mitochondrion. To investigate the effects of exhaustive exercise on the expressions of genes and proteins related to mitochondrion fusion/fission in Hippocampus.

Methods: Seventy rats were distributed into two groups at random: Control Group(abbreviated to C, n=14), and Exhaustive Exercise Group (abbreviated to EE, n=56).Then EE Group were divided again into different groups based on time (immediately, 12, 24 and 48h), named immediate Group (abbreviated to EE0), 12h Group (abbreviated to EE12), 24h Group (abbreviated to EE24), 48h Group (abbreviated to EE48). Groups EE underwent one-time exhaustive swimming, then every 14 rats were executed at four time points: immediate, 12, 24 and 48h after one-time exhaustive exercise. The morphological structure of the hippocampus neurons and mitochondrion would be observed using transmission electron microscopy; the mRNA and protein level of genes related to mitochondrion fusion mitofusin1/mitofusin2 (Mfn1/2), and genes related to mitochondrion fission Dynamin-related protein1 (Drp1) were detected.

Results: It was found that the neurons of rat in group C were normal, but the rats’ hippocampus neurons appeared irregular in group EE0, EE12 and EE24, the cytoplasm showed a large number of vacuoles, most mitochondria in swelling deformation, crest structure fuzzy or broken even vacuolated; the integrity of mitochondrial was damaged. 48h after exhaustive exercise, the neurons form and nucleus structure of group EE48 recovered to normal. The cytoplasm was uniform, intracellular organelles were abundant, the morphological structure of mitochondrial was natural, and the quantity of mitochondria in the cytoplasm got increased. The transcription and protein expression of Drp1 and Mfn1/2 were significantly increased at each time point in group EE when compared with group C(p<0.05), and the expression of Drp1, Mfn1/2 mRNA and proteins in EE0, EE12 and EE24 increased continuously. The balance of Drp1/Mfn1/2 won't been kept after exhaustive swimming.

Conclusion: Exhaustive Exercises can induce mitochondrial dynamics depending on different expressions of mitochondrial fusion/fission genes and proteins. The balance of Drp1/Mfn1/2 will been disturbed after exercises.

Using DT-MRI and 31P-MRS to Assess Muscle Damage Following Unaccustomed Eccentric Exercise

Deng W.Q., Wang L., Li P., Ma H.H., Zhao Y.N.

Department of Sports Medicine, Chengdu Sport Institute, Chengdu, China

Objectives: To detect the musculoskeletal structure and metabolism changes invivo by diffusion tensor magnetic resonance imaging (DT-MRI) and 31P-Magnetic resonance spectroscopy (31P-MRS) after a single bout of eccentric exercise.

Methods: Thirty two male Sprague Dawley rats (body weight 238±15g) were randomly divided into either a sham group (n=8) or a downhill running group (n=24). Rats in the downhill running group ran 120min on treadmill at a speed of 20m/min at −16 degrees grade. DT-MRI and 31P-MRS were performed in right lower limb at pre-exercise (sham), immediately, 24 and 48h post-exercise at 7T MR. The MR sequence included RARE T2, RARE T1 and EPI-DTI. MRS observational indices included the peak areas of inorganic phosphate concentration (Pi), phosphocreatine concentration (PCr) and the ratio of Pi/PCr.. The morphological changes were confirmed by histological and immunohistochemical methods. One-way ANOVAs and Tukey's test were used to assess the differences among different time points.

Results: On diffusion tensor tractography images, a single bout of downhill running significantly disrupted muscle fiber structure. The peak areas of Pi were significantly higher after exercise (pre-exercise: 4.1±0.8mM; 0h post-exercise: 4.7±1.4mM; 24h post-exercise: 6.6±1.9mM; 48h post-exercise: 6.1±1.7mM; all p<0.01). Muscle PCr did not differ between pre- and post-exercise; consequently, Pi/PCr values were significantly higher following EIMD (pre: 0.14±0.05; 0h post: 0.18±0.05; 24h post: 0.22±0.08; 48h post: 0.2±0.08; all p<0.05). According to the histological detection, Z-band streaming was higher post-exercise compared with baseline (all p<0.05). The histopathological indices of damage coincided with changes in DT-MRI parameters of fractional anisotropy and apparent diffusion coefficient.

Conclusions: The data suggest that exercise-induced muscle damage was accompanied by structural and metabolic alterations in skeletal muscle following a single bout of downhill running. The ability of DT-MRI and 31P-MRS to accurately detect these changes invivo makes them promising approaches to evaluate skeletal muscle damage after unaccustomed exercise.

Acknowledgements: This research is supported by the National Natural Science Foundation of China (Grand No. 81301195) and the Innovation Project of Institute of Sports Medicine and Health Chengdu Sports Institute(Grand No. CX17A05)

An Efficient Method for Exploiting Driving Pathways in Gene Network About Mutation Cancer Gene

Chen Y.Y.¹, Dai W.²

¹Computer Center. Kunming University of Science and Technology, Kunming 650500, China; ²Computer Technology Application Key Lab of Yunnan Province, Kunming University of Science and Technology, Kunming 650500, China

Background: Because distinguishing mutations driver pathways plays an important role in the progression of cancer pathogenesis, somatic mutations causing cancer can be studied through genome sequencing, which mainly contribute to the pathogenesis of cancer by detecting driving pathways in gene network. However, genome sequence presents a dynamic state of mutual relationship between each pair of genes actually. What's more, mutation gene data coming from different patients can be detected the maximal relational subgraph with high superpose.

Methods: The paper focuses on design and implementation an attribute reduction algorithm to extend the distance of intersecting neighborhood rough set and to build maximal relational subgraph based on eliminating redundant relationship of genes. Then, the paper presents an efficient method for detecting somatic mutation gene driving pathway in gene network for tumors based on exclusive mutational property. Caner data come from the Cancer Genome Atlas (TCGA) was sequentially implemented by reduction algorithm and driving pathways method.

Results: Experimental results on leukemia and lung carcinoma data sets show that attribute reduction algorithm simplifies the mutual relationship among cancer genes and prevent key data lost in continuous numeric data. The somatic mutation gene driving path provides can be quickly detected with more biological gene relationship and higher statistically significant pathways.

Conclusion: Based on mutation gene network, the algorithm simplifies gene relationship and exploits more efficiently and accurately of detecting pathways.

Acknowledgments: The National Natural Science Foundation of China; Foundation Number: 11103005 and U1631129. Department of science and technology of Yunnan Province; Foundation Number: 2017FB001.

Interaction of Flavonoids with Biomolecules by Flow-injection Chemiluminescence and Fluorescence

Gao S.Y.^1,2, Zhang Y.¹, Wang L.¹, Hu B.Q.¹, Tang Y.M.¹

¹School of Pharmacy, Xi'an Medical University, Xi'an, Shaanxi, China; ²Institute of Medicine, Xi'an Medical University, Xi'an, Shaanxi, China

Background: Flavonoids, from traditional Chinese Medicine, are a series of compounds that are connected to each other through three carbon atoms by two phenols (A- and B- rings) with phenolic hydroxyl groups. Research shows that flavonoids have a variety of different pharmacological functions such as antioxidant, antiviral, antidiabetic, antibacterial, anti-inflammatory and so on. In this experiment, the flow-injection chemiluminescence (FI-CL) and fluorescence were introduced to investigate the interactions of seven flavonoids (baicalin, catechin, genistein, isorhamnetin, rutin and chrysin) with bovine serum albumin (BSA).

Methods: The chemiluminescence system of luminol – BSA was established with the optimized concentration of luminol and BSA by 2.5×10⁻⁵ and 2.5×10⁻⁹mol/L, respectively. Two peristaltic pumps, equipped with an automatic sampler, were used to deliver all solutions at a flow rate of 2.0mL/min. Injection was made using a six-way injection valve equipped with a 100μL sample loop. The flow cell was a 10.0cm length of glass tubing and was positioned in front of the detection window of the photomultiplier tube, operated at −700V. Four flow lines were inserted into the solutions of luminol, carrier (purified water), BSA and sample, respectively. The concentration of the flavonoids was quantified by the decrement of CL intensity.

Results: In experimental investigation, a good linear relation between the interaction of drugs and BSA proved that the assumption of 1:1 combination ratio of seven flavonoids with BSA was basically reasonable. The binding constants of them were more than 5.0×10³L/mol, respectively. In addition, a contrast was performed to verify the consistency of their results by FI-CL and fluorescence. Furthermore, this method also was successfully used to determine flavonoids in pharmaceutical formulation, human saliva, and serum samples without interference.

Conclusions: FI-CL method was developed to determine the interaction of flavonoids with BSA. The results were satisfactory and this method has several advantages such as simple, fast, sensitive, wide linear range, etc. It could provide an experimental basis for the study of the interaction between drugs and proteins.

Acknowledgments: Supported by a provincial key discipline-pharmacy (1007) and its construction project from Xi'an Medical University (No. 2016YXXK19) and the Undergraduates’ Innovative Training Program (No. 2280, 2334).

Camouflage Pattern Painting Design Based on Animal Bionics and Mathematical Morphology

Jia Q., Lv X.L., Xu W.D., Hu J.H., Liu J.

College of Field Engineering, Army Engineering University of PLA, Nanjing, Jiangsu, China

Objectives: With the rapid development of computer graphic and image processing technology, the animal bionics and clustering algorithm and mathematical morphology algorithm have been widely applied in image object recognition and image segmentation and processing. Animals are teachers of human camouflage. The mathematical morphology algorithm is more perfect than traditional algorithms in image detail processing and edge detection. Mathematical morphology is based on the idea of information exploration, and the human Focus Of Attention (FOA) is similar in visual characteristics. As an effective mean to combat enemy detection and interference information gathering, the camouflage can effectively prolong the time of discovery and shorten the detection distance.

Methods: The paper focuses on camouflage pattern painting design based on animal bionics and mathematical morphology. Design of camouflage spots is based on animal patterns. The demand of pattern painting is analyzed in detail, including the design principle, basic color, combing size, etc. Then, the design of the several pattern painting is finished, including 4 basic operations, such as expansion, erosion opening and closing, and their combination operations. Variety backgrounds are selected in design in order to ensure the accuracy and applicability. Finally, the camouflage effect contrast experiments are completed, including computer simulation and practical experiments.

Results: The camouflage pattern painting is designed that mainly consisted of several colors, which is determined by the surrounding background. The results of camouflage effect simulation evaluation based on human visual attention mechanism show that, the design based on mathematical morphology has a better effect than traditional methods. The organized field personnel observation experimental results also verify this.

Conclusion: The camouflage pattern painting using clustering and mathematical morphology is realized and the camouflage effect is experimented. The pattern based on combination of morphology operation has the best camouflage effect.

Acknowledgements: Supported by a project grant from Key Laboratory on Electromagnetic Environment Effects and Electro-optical Engineering (Grand NO. FD2015011).

Biomechanical Modeling and Its Finite Element Solution of Human Muscle Tissue

Wang M.N., An X.J.

Harbin University of Science and Technology, Harbin, China

Objectives: Virtual surgery system is a typical application of virtual reality technology in digital medicine. Its significance lies in the surgery planning and surgery training so that we can decrease the risk of operation failure. As the important part in the virtual surgery system, biomechanical modeling and its solution module of human tissue is closely connected with the simulation precision of whole system. This research mainly aimed at the research of the biomechanical modeling and its solution method of human muscle tissue.

Methods: At first, we introduced the anatomical structure of the human muscle tissue and its biomechanical properties. We take human muscle tissue as the approximate incompressible nonlinear hyperelastic material and build a biomechanical model combining the exponential and polynomial models. Second, according to the finite element method and the theory of continuum mechanics, we calculate the biomechanical modeling of human muscle tissue. Considering both the energy and material, we combine the principle invariants with Green strain to solve material nonlinearity problem. To solve the geometric nonlinear problem, we divided the strain tensor into two parts of linear and nonlinear. The process of this solution is implemented in the Visual Studio environment. At last, through the comparison of the data from the simulation of compress and tensile and the data from experiment, we verified the validity of biomechanical modeling and solution program.

Results: The maximum error between the simulation results and the experimental results was found to be 0.00149MPa which meets the requirements for the virtual surgery system for the accuracy of human tissue models.

Conclusions: The model and finite simulation result are accurate. This method can was applied to simulate human muscles.

Acknowledgements: This research was supported by NSFC (No. 61572159), Scientific Research Foundation for the Returned Overseas Scholars of Heilongjiang Province and Harbin University of Science and Technology Youth Talent Support Program.

Design Implementation of Femoral Prosthesis Based on Finite Element Method and Fuzzy Matter-element Optimization Method

Wang M.N., Li C.Q.

Harbin University of Science and Technology, Harbin, China

Objectives: The shape and size of the human femur vary among individuals, especially those with congenital malformations. A standardized prosthesis can thus not be expected to meet the requirements of various patients. To avoid mismatch with a patient, scholars have proposed the design of a customized femoral prosthesis based on a reconstructed 3D model of the femur of the specific patient. The aim of this study was the development of a method for producing an optimized femoral prosthesis for specific patient using material-property analysis and fuzzy matter-element analysis.

Methods: In this study, we employed an finite element model for the mechanical analyses of prostheses of different structures and materials, and got the results for structural optimization and parameters calculation of various material models of a femoral prosthesis, such as the rated load, fatigue life, stress shielding rate, and maximum deformation. The spherical, ellipsoid and limacon femoral head structure were analyzed. The zr-nb alloy, zirconia ceramic and carbon-fiber-enhanced polyether-ketone composite material were considered. Finally, we used a fuzzy matter-element optimization method for the multi-objective comprehensive evaluation of the prosthesis, including the determination of the ideal material for its production.

Results: When the acetabulum matches respectively with three different shapes of femoral heads, the maximum deformation is 0.037435, 0.024877 and 0.061550mm under the same load. The maximum stress of femoral head is 10.25, 5.39 and 12.19Mpa. The results predicted that ellipsoid femoral head is the optimized structure for this patient. The suitable material for the ellipsoidal femoral head of the prosthesis was determined to be a carbon-fiber-enhanced polyether-ketone composite, and that for the stem was determined to be a Zr–Nb alloy.

Conclusions: The study successfully established a better and more general femoral prosthesis optimization system.

Acknowledgements: This research was supported by NSFC (No. 61572159), Scientific Research Foundation for the Returned Overseas Scholars of Heilongjiang Province and Harbin University of Science and Technology Youth Talent Support Program.

Research on Operational Risk Evaluation of Online Pharmaceutical Industry Supply Chain Finance Based on Fuzzy AHP

Wang D.¹, Wang B.S.²

¹College of Management and Economics TianJin University, Tianjin, China; ²School of Economic of Beijing Wuzi University, Beijing China

Objectives: With the combination of Internet and supply chain finance, the financial supply of Internet supply chain has developed rapidly, and has become an effective solution of the financing problem of SMEs. The Internet financial supply chain using the Internet and IT technology to build the platform of supply chain finance, to realize each node enterprise financial services and supply chain seamless docking, realize information exchange and data collaboration, integrate and redistribute the resources of supply chain, improve the economic benefits of the whole industry chain. How to enhance the supervision and management of the financial operation of the Internet supply chain has become the key to control the financial risk of supply chain. This paper builds an accurate evaluation index system of Internet financial operational risk, to control the risk of online supply chain by monitoring the operation risk periodically.

Methods: The paper constructs four stage evaluation index system, e-commerce transactions, online transactions, online payment transaction information, logistic operational. The paper uses the fuzzy evaluation mathematical model to assess the Internet financial risk of supply chain operation. Assess the case of Beijing Rong Ke Sheng Da Pharmaceutical Technology Co. Ltd. – “financial services platform”, to quantify the operational risk, risk analysis and put forward risk prevention measures.

Result: To assess the operational risk of online supply chain finance, we can not only understand the supply chain financial transaction stage, but also grasp the overall risk situation, and make operational risk management decisions in a timely manner. In the present situation, the operation risk of Internet supply chain finance is on the high side, among which the operation risk is the most significant. Online logistics enterprises need to establish effective supervision system and warehouse management system, strengthen the pledge and warehouse management, improve the network information management level, to reduce the risk of operation.

Research on Chinese Pharmaceutical Industry Based on Multivariate Statistics

Li Y.J., Lyu Z.D.

Beijing University of Posts and Telecommunications, Beijing, China

Objectives: China's population accounts for 22 percent of the world's population, whose requirements on the quality of life provide a huge potential market of health economy. With the accelerating pace of urbanization, the pressure of life is increasing, and the health problems are caused for concern. At the same time, China gradually came into the aging society; currently, there are 130 million people over the age of 60, accounting for the world's total population of 1/5, and Asia's 1/2. The proportion of the elderly population has increased by 5.4% per year since 2000. The domestic demand for medical care and health brought by aging society has increased gradually. Health care economy is the sunrise industry in China's economic industry. In September 2013, the State Council of China issued “Opinions on promoting the development of health service industry”, which promoted the development of health economy to the national strategic level.

Methods: Chinese pharmaceutical industry is mainly divided into five sub sectors as traditional Chinese medicine, chemical medicine, biological medicine, medical equipment and pharmaceutical business. The pharmaceutical industry has the characteristics of high technology, high risk, high added value and high investment. In view of these characteristics, this paper studies China's pharmaceutical manufacturing from three aspects. For the patent data is closely related to the enterprise's technological innovation ability, on one hand, use descriptive statistical methods to study the situation of patent development in pharmaceutical industry. On the other, due to the high-tech industry cluster is the most successful model to develop the high technology industry, use correspondence analysis and graph representation of multivariate data to research the construction of Chinese Pharmaceutical Industrial Park. What is more, study the output value of pharmaceutical industry through factor analysis and correspondence analysis, and sort out the disclosure of social responsibilities from pharmaceutical companies.

Results: The new technology and products in Chinese pharmaceutical industry are constantly emerging, and the number of patent applications has shown an upward trend. The number of invention patents in China ranks the middle of the world, and the level of technological innovation is high. From the perspective of the resource allocation of patent technology, each category has its own focus. The construction of industrial parks has been supported by the government and the Yangtze River Delta, Bohai rim and Northeast China have become the most concentrated areas of Chinese biopharmaceutical industry parks. The output value created by pharmaceutical enterprises is higher than other high-tech industries, and the social responsibility is also great.

Conclusions: The high-tech industry cluster has become the most successful model to develop the high-tech industry, and the biopharmaceutical enterprises should learn from each other and promote the development benignly. From the report of listed pharmaceutical companies’ social responsibility, there is still a need to strengthen the disclosure of social responsibility.

Acknowledgements: Supported by a project grant from National Natural Science Foundation of China (Grand No. 11471051).

Construction and Application of Soil Information Database of Tropical Arable Land Soil: A Case Study of Hainan Island, China

Ye J.Q., Wang D.F.

Tropical Crops Genetic Resources Institute, CATAS, Danzhou 571737, China

Objectives: Soil weathering is a slow, continuous process and is affected by human activities, especially in the tropical region. In a nature environment with high temperature and high humidity, a continuous high multiple cropping index and unreasonable fertilization lead to complicated evolutions of soil quality in tropical areas. In order to clarify the influence of human activities and natural weathering on soil properties and nutrient distribution, it is necessary to establish a regional scale soil resource information database based on time series.

Methods: Taking Hainan Island as an example, the data of the second soil census during the 1980s were collected, then the spatial information of the sampling points was identified according to the informational description of the point and the soil type. Further the fertility evaluation results of the arable land in Hainan County from 2008 to 2011 were taken as the second time period data. The comparison of the indicators and the feature identification of spatial distribution of the two time periods were performed with spatial analysis tools.

Results: During the past 30years, the soil of Hainan Island was continuously acidified. The soil pH is reduced by 0.33 units. Soil organic matter content also demonstrates different levels of reduction, with the maximal decline of 10g/kg. The content ranges of available N, P and K tend to narrowed, and the contents are increased. Changes in soil nutrient and organic matter content are mainly due to over-reliance on chemical fertilizers and insufficient input of organic fertilizers in agricultural production over the years.

Conclusion: The soil resource information database can be used to identify the soil evolution process at different time periods. It is conducive to the study of the distribution and evolution of large-scale soil properties and nutrients in a medium-long time scale. In addition, it is an open access database, therefore the data can be expanded on time and space scales according to prior data, further improving its application.

Acknowledgments: Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (No. 1630032017042).

Effect of Horticultural Therapy on Psychological Factors of Patients with Hand Functional Rehabilitation

Huang W.Z.¹, Liu L.², Wang Z.J.¹, Mai G.H.¹, Cui S.Y.¹, Yan W.¹

¹Rehabilitation Institute, The Fifth people's Hospital of Foshan, Foshan 528211, China; ²School of stomatology and medicine, Foshan University, Foshan, 528000, China

Objective: To observe the effect of horticultural therapy on psychological factors of patients with hand functional rehabilitation

Method: Sixty-six cases of hand dysfunction patients with postoperative hand trauma were randomized into observation group (n=33) and control group (n=33) according to the random number table method. All patients were given routine basic rehabilitation exercise therapy. The observation group was given horticultural operations, including garden plant care, crop production, potted combination, flower art training, landscape design training and planting herbs. The Beck Depression Scale (BDI), Behavioral Inhibition Scale (BIS), Behavioral Activation System Scale (BAS) and Resilience Scale (CD-RISC) were assessed in all patients before treatment and after 4weeks treatment.

Result: (1) There was no significant difference in the scores of BDI, BIS, BAS and CD-RISC between the two groups of patients before treatment (p>0.05). The BDI score(7.92±3.16 score) and BIS score(11.13±2.45 score)in the observation group after treatment were significantly lower than those of the control group(10.25±3.68 score and 15.42±2.36 score, respectively) and the differences between groups after treatment were statistically significant(p<0.05). Both BDI and BIS scores were significantly lower than those in the group after treatment (p<0.05). (2) The BAS score and CD-RISC score of the two groups of patients were significantly improved after treatment. The BAS score (40.33±3.65 score) and CD-RISC score(89.14±5.23 score)in the observation group were significantly higher than those of the control group (37.12±4.65 score and 80.15±4.31 score, respectively) and there was significant difference between groups after treatment (p<0.05).

Conclusion: Horticulture therapy has a good effect on the rehabilitation of mental disorders in hand dysfunction patients with postoperative hand trauma.

Key word: Horticultural therapy, hand function, rehabilitation, psychology, hand trauma

Acknowledgement: Supported by medical research fund project of Guangdong(NO: A2013686), Special fund for science and technology development of Foshan(NO: 0008016A), Medical Science and Technology Research Project of Foshan (NO: 2017AB000079), Key Medical College Training Project of Foshan (NO: Fspy3-2015027) and 13th Five-Year Focus On Specialty Construction Projects of Foshan (NO: FSZDZK135033).

The Value of Horticultural Rehabilitation Therapy on Hand Function

Huang W.Z.¹, Liu L.², Wang Z.J.¹, Mai G.H.¹, Cui S.Y.¹, Yan W.¹

¹Rehabilitation Institute, The Foshan Fifth people's Hospital, Foshan 528211, China; ²School of stomatology and medicine, Foshan University, Foshan, 528000, China

Objective: To observe the adjuvant effect of horticultural therapy on hand function rehabilitation of patients with hand trauma operation.

Method: sixty cases of patients with the rehabilitation period of hand trauma were randomized into observation group (n=30) and control group (n=30) according to the random number table method. All patients were given routine rehabilitation treatment. The observation group was given auxiliary horticulture therapy in the horticultural garden such as plant therapy, aromatherapy, flower therapy, herbal remedies and art therapy with 4weeks treatment. The index changes such as the improvement of hand symptoms before and after treatment, Evaluation of Total active motion (TAM), Minnesota manual dexterity (MMDT) and Purdue pegboard assessment systems (PPT) were evaluated in all patients.

Result: (1) The improvement rate of tactile sense recovery, edema, infection, pain and muscle atrophy in the observation group was significantly higher than that in the control group and there was significant difference between groups after treatment. (p<0.05). (2) The excellent and good rate of TAM in the observation group was higher than that in the control group (p<0.05). (3) Comparison of MMDT results in the two groups is that the average storage time and the average turnover time of the observation group were significantly lesser than that of the control group (p<0.05). (4) The results of PPT in the two groups were compared. The number of the steel column inserted into the steel groove with the affected hand and the two hands and the number of the sets assembled in the specified order with the two hands were significantly better than those of the control group (p<0.05).

Conclusion: Horticultural therapy has a good adjuvant treatment effect on the improvement of symptoms and the improvement of the rehabilitation of hand function in patients with hand trauma surgery.

Key word: Horticultural Therapy; Hand trauma; Rehabilitation; Adjuvant; Hand Function

Acknowledgement: Supported by medical research fund project of Guangdong(NO: A2013686), Special fund for science and technology development of Foshan(NO: 0008016A), Medical Science and Technology Research Project of Foshan (NO: 2017AB000079), Key Medical College Training Project of Foshan (NO: Fspy3-2015027) and 13th Five-Year Focus On Specialty Construction Projects of Foshan (NO: FSZDZK135033).

A Literature Review of Investment in China's Agricultural Bio Industry in CNKI

Liu N¹, Han Y¹, Liu B²

¹College of Economics and Management China Agricultural University, Beijing China; ²College of Economics and Management Yanshan University, Qinhuangdao China

Objectives: To understand research situation of the investment in China's agricultural Bio Industry

Methods: Statistical analysis based on CNKI

Results: Usually Chinese scholars consider separately investment in agriculture and Bio Industry respectively. From the CNKI papers, Chinese scholars first direct discussion of agricultural investment in 1996, Liu Hong published his thesis, in the “Rural Development Forum” and in the “economic work Guides” namely: “agriculture, cross century sunrise industry - agriculture project has become the new focus of investment industry”. After this article, the total number is 334, especially from 2009 to 2016 there are 20 papers published each year. In these articles, there are 184 articles of newspapers and 128 papers of journals, keywords used frequently are agricultural investment funds, agriculture, industrial investment funds, venture capital, foreign direct investment, agricultural industry, agricultural high-tech industry, agricultural technology, agricultural industrialization and investment in agriculture etc. Roughly the same time as the investment in agricultural industry, Chinese scholars have begun to study the investment in bio industry. The earliest document in CNKI was published by “the progress of biological engineering” in 1995. Since twenty-first Century, the biological industry has shown a spurt of development, and more and more studies have been done. In CNKI, every year from 2007 to 2016 there are more than 100 articles included in “Bio Industry” of Title Direct literature, most of the year is more than 200 articles, the total number of documents directly included in “Bio Industry Investment” title to there be more than 50 articles.

In fact, “agricultural Bio Industry” also appeared early in china. From the CNKI, in early 1994, “agricultural biotechnology industry will slow growth” was published by Wang Ying in the “steady biotechnology bulletin”. In Wang-Ying's article, the Frost & Sullivan company (F&S) (Mountain View CA) Market Research Report on agricultural biotechnology industry were reviewed. Subsequently, every year there were 198 articles on the agricultural bio industry. Only 4 of these articles are entitled “investment in agricultural biological industry”. In these four papers, Tang Ligui's master thesis of Southwestern University “ The evaluation of agricultural biotechnology industry risk investment project “ (2006) focused on the evaluation method and index system of the risk investment project of China's agricultural biotechnology industry; Liu Yongchan and Li Jianhua in “on the Taiwan agricultural biotechnology industry development strategy and investment situation” (Taiwan agricultural research, 2005) introduced the development level, achievements and existing problems of Taiwan agricultural biotechnology industry and investment in the mainland.

Conclusions: Look from CNKI, the number of Chinese scholars on investment in agricultural bio industry is not large, and the research depth is not enough, which needs further promotion.

Acknowledgements: Supported by a project grant from Asian Development Bank Technical Assistance Project “foreign investment promotes the development of agricultural modernization in china” (Grand No. TA8711-PRC).

The Distribution Proportion and Production of Vegetables in Tropical Area: A Case Study of Hainan, China

Niu Y., Du G.F., Yang Y.

Tropical Crops Genetic Resources Institute, CATAS, Danzhou 571737, China

Objectives: Vegetables are important source of nutrition in humans, and their market supply has a significant impact on human health. Currently in China, the vegetables supply is seasonal, regional and structurally shorted. In recent years, the transport of vegetables from South to North of China is still the major source to solve the dwindling vegetable supply in winters and springs. The optimization of the area for plantation is an essential task, and can be made possible after analyzing the growth pattern of vegetable industry in the hotter areas. For example, the analysis of developmental characteristics of regional vegetable industry in Hainan over the past 20years has been of great significance in the planning and macro regulation of vegetable industry in hotter areas.

Methods: The data of sown area and yield of vegetables in Hainan was obtained from Statistical Yearbooks of Hainan. The data was processed by SAS 9.0.

Results: In the past 20years, the total output of vegetables in Hainan has increased dramatically, from 360,000tons in 1990, 5.33million tons in 2010–5.84million tons in 2015. It should be noted that from 2006 to 2015, the vegetable area in Hainan increased significantly from 120,226 hectares to 299,862 hectares, indicating a remarkably increased demand for vegetables during this period, which is closely related to the improvement of social health awareness. Considering individual contribution, the area for pepper and cucumber gradually reduced, whereas the area for watermelon, cantaloupe and leaf vegetables increased, indicating the diversified development of market demand.

Conclusion: Although Hainan is one of the highest producers of vegetables, it lacks proper technology and market information transmission, in addition to the low level of industrialization in vegetable business. In the future, more attention needs to be paid to the improvement of diversity and quality of vegetables, optimizing the industrial structure, developing special vegetable varieties, as well as forming a robust industry model with a reasonable structure and diversified supply.

Acknowledgments: This research was supported by Major Science and Technology Projects of Hainan (ZDKJ2017001) and National Nonprofit Institute Research Grant of CATAS-TCGRI (1630032015015).

Distribution of Macro and Trace Elements in Cashew Leaves

Huang H.J.¹, Huang W.J.¹, Zhang Z.R.¹, Zhao L.²

¹Tropical Crops Genetic Resources Institute, CATAS, Danzhou 571737, China; ²College of Applied Science and Technology, Hainan University, Danzhou 571737, China

Objectives: Cashews are rich in nutrients and are an important health food. While the yield of cashew nuts is low, making it difficult to meet the market demand. Research on cultivation technology giving high yields of cashew nuts has attracted academic attention. The studies have focused on genetic breeding, cultivation and management techniques, pest control. Accordingly, for exploring the highly efficient fertilization technologies, it is essential to understand the nutrient distribution in cashew leaves, because no systematic studies on the nutrient distribution in cashew leaves have been carried out yet.

Methods: A total of 36 systematic sampling sites have been setup according to the plant yield and topographic features of the orchard. The top leaves of the fruit bearing twigs at different nut forming times were collected and the N, P, K, Fe, Mn and Cu contents were analyzed to determine their patterns of changes.

Results: The N, P and K contents of cashew leaves were significantly different at different stages of the annual growth cycle. The demand of N, P and K varied at different stages, out of which nitrogen and potassium had a significant effect on the yield of cashew nuts. The Fe, Mn and Cu contents in cashew leaves were related to their annual growth cycle. The growth of cashew trees becomes active in Oct., accumulating nutrients for the subsequent differentiation of flower buds and fruit growth, with a gradual increase in the contents of trace elements in leaves. During the fruit setting stage in Mar. of the following year, large amount of nutrient is consumed, leading to a gradual decrease in the nutrient content of leaves.

Conclusion: For a proper nutrition management of cashew nuts, the dynamic changes in the major and trace elements in the leaves should be fully determined. Before the nutrient consumption period, which is before Mar., an appropriate amount of nutrients should be supplied to the plant. Likewise, after the cashew harvest, an appropriate amount of trace elements should be added to make up for the nutrient loss caused by harvesting.

Acknowledgments: This research was supported by the Ministry of Agriculture Tropical Crop Germplasm Resources Protection (151721301354052012); the National Nonprofit Institute Research Grant of CATAS-TCGRI (1630032017010; 1630032017011).

The Functional Study of Baihe Zhimu Decoction on Anxiety and Depression Rats

Li X.B.¹, Li Y.J.¹, Zhao X.¹, BX M.A.¹, Gao X.L.¹, Li N.², Wang J.M.¹, Xie Z.L.¹, Liu X.H.¹, Zhang Y.T.³, Ding Y.W.¹

¹Henan University of Chinese Medicine, Zhengzhou, China; ²The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China; ³Guangzhou University of Chinese Medicine, Guangzhou, China

Objectives: The present study was to investigate the antidepressant-like effect of Baihe Zhimu Decoction(BZD)and its relevant mechanisms.

Methods: The depression rats were induced by an chronic, unpredictable, mild stress (c*ms) procedures and subsequently BZD was administered orally. The antidepressant effect was evaluated by sucrose preference test, open-field test (OFT), tail suspension test (TST), forced swim test (FST) and morris water maze test. Besides, The serum corticosterone(CORT) and brain-derived neurotropic factor (BDNF) were test in brain tissue by ELISA. Superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in brain tissue were also analyzed.

Results: c*ms reduced open-field activity, sucrose consumption, as well as increased immobility duration in FST and TST. BZD could effectively reverse alterations in immobility duration, sucrose consumption, and open-field activity. the changes of serum corticosterone level and BDNF level in brain tissue were reversed by BZD intervention. Compared with model group, BZD treatment reduced MDA level in brain tissue.

Conclusions: BZD significantly improved depression-like behaviors in c*ms rats and its antidepressant actions might be mediated by regulation of MDA, corticosterone and BDNF levels in brain.

Acknowledgments: Supported by a project grant from The Key Scientific Research Projects of Henan Province Colleges and Universities (Grant No. 16A360010), The Science and Technology Project of Zhengzhou City (Grant No. 20150310), The Young Key Teachers of Colleges and Universities in Henan Province (Grant No. 2016GGJS-080).

Medicinal Property Matter and Meridian Tropism of Gardenia jasminoides Based on a Systemic Method of “Syndrome Efficacy Analysis of Biological Samples”

Wang J.M.^1,2, Zhang Y.Y.¹, Duan P.L.¹, Cui Y.^1,2, Shi Y.R.¹, Li Q.¹, Li J.Y.¹, Li X.B.¹

¹Henan University of Chinese Medicine, Zhengzhou, China; ²Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou, China

Objectives: Medicinal property theory (MPT), an essential principle of traditional Chinese medicine (TCM) theories, makes an important impact on guiding clinical medications. To clarify MPT clearly will certainly further enhance the reasonable and effective application of TCM. This study was undertaken to observe the medicinal property matter (MPM) and meridian tropism (MT) of Gardenia jasminoides Ellis (GJE) based on a systemic method of “syndrome-efficacy-analysis of biological samples (SEABS)”, for the first time.

Methods: Diabetes complicated with depression (DBCD) was prepared by streptozotocin combined with chronic unpredictable mild stress in mice. GJE aqueous extract (GJEAE) was administered orally to mice at dose 5.68g/kg once a day for seven continuous days. Blood glucose and antidepressant behavioral tests including open field, sugar preference and forced swimming were conducted at appropriate time during the experiment. At 10, 30, 60, 90, 120min after the last administration, biological samples including blood, heart, liver, kidney, spleen, lung, stomach were quickly collected from DBCD mice. HPLC assay was used to determine concentration of geniposide (GP) in above biological samples, and software DAS 3.0 was used for pharmaco*kinetic parameters.

Results: GJEAE ameliorated DBCD, evidenced by significantly decreased blood glucose and antidepressant effects in mice. GP was detected in serum and all tissues after administration of GJEAE for 10–120min in mice. Pharmaco*kinetic parameters were as followed by AUC0-t (mg/L·min) 125.55, 2713.95, 732.45, 4854.90, 4069.65, 1597.80, 2105.55, t1/2z (min) 46.97, 54.76, 136.50, 46.61, 60.87, 82.58, 31.70, and CLz/F (L/min/kg) 6.51, 0.28, 0.64, 0.17, 0.19, 0.39, 0.47 in serum, liver, lung, kidney, stomach, heart and spleen.

Conclusions: These findings indicate that GP is one of the main MPM of GJE, and GJE can be likely to mainly enter heart, lung, liver, kidney, stomach, which is basically similar to traditional knowledge.

Acknowledgements: Supported by project grants from the National Natural Science Foundation of China (Grants No. 81503269 & 81473368).

Study on Concocted Toxicity-reduced Effects of Tripterygium wilfordii Using Glycyrrhiza uralensis Fisch. in Mice Implanted with S180 Cells

Wang J.M.^1,2, Li J.Y.², Cai H.², Zhang Y.Y.², Chen R.X.², Zhang Z.L.^1,2, Li J.H.², Rong C.L.³, Li X.B.⁴, Li J.², Cui Y.^1,2

¹Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, 450046, China; ²College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China; ³The First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, 450000, China; ⁴College of Basic Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China

Objectives: Tripterygium wilfordii Hook F (LGT) has outstanding clinical efficacy but great toxicity. Glycyrrhiza uralensis Fisch. (GC) can often ease drugs or food poisoning due to Gan slow of medicinal property in the theory of traditional Chinese medicine (TCM). This study aimed to observe the concocted toxicity-reduced effects of LGT using GC in mice implanted with sarcoma S180 cells, and its potential mechanisms.

Methods: Concocted products of LGT were prepared by boiling in water together with the GC extract until all liquid had evaporated. Raw and concocted LGT products were used to prepare ethyl acetate refluxing extractions (EAREs). Each EARE was orally administered to mice for 14 consecutive days at 60mg/kg. Serum biochemical markers were used to assess the anti-toxicity action, and liver and kidney tissues were analyzed to assess its preliminary mechanisms.

Results: LGT raw material induced conspicuous increase in serum ALT, AST, Cr, and BUN levels, and tissue MDA, and significant reduction in SOD, CAT, GST and GPx in liver and kidney tissues. The above abnormal indicators were all significantly reversed by concocted by GC. Furthermore, histopathological examination suggested that LGT raw material caused conspicuous tissue injury of livers and kidneys. However, no obvious injury was detected in tissues from the mice treated with the concocted product of LGT by GC.

Conclusions: Concocted with GC could reduce the toxicity induced by LGT, with an underlying mechanism of inhibiting oxidative stress damage in mice implanted with sarcoma S180 cells.

Acknowledgements: Supported by project grants from the Program for Science & Technology Innovation Talents in Universities of Henan Province (Grant No. 16HASTIT032), the National Natural Science Foundation of China (Grant No. 81503269), the Science and Technology Innovation Talent Fund of Henan Chinese Medicine (Grant No. 2015XCXRC01), the National Science Foundation for Post-doctoral Scientists of China (Grant No. 2012M521412), the Provincial Fundamental Research Fund in Henan University of Chinese Medicine (Grant No. 2014KYYWF-QN01), and the Doctoral Research Fund of Henan Chinese Medicine (Grant No. BSJJ2010-22).

Selaginella Flavonoids Suppress VCAM-1 and E-selectin Expression in TNF-α-treated Human Umbilical Vein Endothelial Cells by Blocking NF-κB Activation

Wang X.L.^1,2, Liu C.X.³, Zheng X.K.^1,2

¹Henan University of Chinese Medicine, Zhengzhou, 450046, China; ²Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment ﹠ Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China; ³Furen Medicine Group Co, LTD, Zhengzhou, 45000, China

Background: Flavonoids is the main consistuents of Selaginella tamariscina (Beauv) spring (TFST), a medicinal herb has the effects of anti-inflammation and hemostatic, which have long been used in traditional Chinese Medicine. Selaginella Flavonoids isolated from Selaginella, have perfective effects such as anti-diabetics, anticancer, antioxidation and promoting the endothelial proliferation and upregulating vascular endothelial growth factor (VEGF) in human umbilical vein endothelial cells (HUVECs). In this study, we observed TNF-α-induced HUVECs increase in IκBα degradation in concert with NF-κB p65 activation was inhibited by treatment with TFST.

Methods: HUVECs were cultured in M1640 and used in experiments. The cells were randomly divided into six group, control, TNF-α and TFST (5, 10, 15, 20μg/mL)groups. Cells of TNF-α group were incubated with concentration (10ng/mL) for 24h, Cells of TFST groups were incubated with the different concentrations(5,10,15, 20μg/mL) of TFST at the same time. HUVEC viability was detected using MTT assay. IL-6,IL-8, NO and ET-1 activity were detected by ELISA. VCAM-1, E-selectin, IκBα and NF-κBp65 were detected by Western blotting. The fluorescence of nucleus intensity of NF-κB and IκBα in HUVECs were analyzed by Laser Scanning Confocal Microscope(LSCM).

Results: TFST was able to increase the number of TNF-α-induced HUVECs, reduce the levels of cytokines IL-6, IL-8, VCAM-1, E-selectin and ET-1. TNF-α caused increases of VCAM-1 and E-selectin expression in HUVECs, accompanied by significant diminution of IκBα and augmentation of NF-κB p65 translocation into nuclei. Treatment with TFST significantly attenuated TNFα-induced upregulation of VCAM-1, E-selectin and IκBα and deregulation of NF-κB p65 translocation .

Conclusion: TFST Suppresses TNFα-induced adhesion molecule expression by blocking NF-κB signaling in HUVECs. The results suggest that TFST may be used to treat and prevent endothelial cell injury-related diseases.

Acknowledgments: The author of this article wants to take this opportunity to thank the NSFC(National Natural Science Foundation of China, 81073034) and the National Science and Technology Major Project (2013ZX09102-022) for financial support.

Alcohol Extract of Coptis chinensis Franch. Exerts Anti-inflammatory and Analgesic Effects by the Involvement of Preventing Lipid Peroxidation and Inflammation

Zhang Y.Y.¹, Liu C.¹, Wang J.M.^1,2, Cai H.², Chen R.X.², Chang X.X.², Cui Y.^1,2

¹Henan University of Chinese Medicine, Zhengzhou, China; ²Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou, China

Objectives: To observe the invivo anti-inflammatory and analgesic effect of the 55% alcohol extract (AE) from the dried rhizome of Coptis chinensis Franch., which is as a classic herbal medicine usually used in clearing the heat, toxic and wet evils in the body according to the traditional Chinese medicine (TCM).

Methods: Alcohol extract of C.chinensis Franch. (AE-CCF) was prepared through common reflux extraction with 55% alcohol, and the yield of AE-CCF was about 26%. The analgesic effect of AE-CCF was evaluated through the conventional tests of hot plate (HPT) and acetic acid-induced abdominal writhing (AAAWT), and the anti-inflammatory effect was evaluated in xylene-evoked ear edema test (XEET) in female Kunming mice. Malondialdehyde (MDA) as the end product of lipid peroxidation and prostaglandin (PG) E2 as an inflammatory mediator were both tested by means of the related literatures.

Results: Compared with the vehicle group (negative control), AE-CCF (260 and 520mg/kg) and ibuprofen (200mg/kg) treatments all significantly increased the pain threshold value in the HPT at 90min after the last administration, while AE-CCF (130mg/kg) did not have such effect. Besides, AE-CCF (260 and 520mg/kg) and ibuprofen (200mg/kg) treatments all significantly reduced the numbers of writhing in the AAAWT as well as the ear swelling degree in the XEET of mice, while AE-CCF (130mg/kg) did not have these effects. Furthermore, AE-CCF administration also significantly reduced the levels of MDA and PGE2 in mice.

Conclusion: AE-CCF produces the invivo anti-inflammatory and analgesic effects at least partially by the involvement of preventing lipid peroxidation and inflammation.

Acknowledgements: Supported by project grants from The Program for Science & Technology Innovation Talents in Universities of Henan Province (Grant No. 16HASTIT032), The Funding Schemefor Young Key Teachers of Colleges and Universities in Henan Province (Grant No. 2014GGJS-072), and The Science and Technology Project of Zhengzhou (Grant No. 20150309).

Anti-toxicity Actions of Tripterygium wilfordii by Concocted Attenuation with Mung Bean (Phaseolus radiates L.) in Mice Implanted with Sarcoma S180 Cells

Wang J.M.^1,2, Li J.Y.¹, Cai H.¹, Chen R.X.¹, Zhang Y.Y.¹, Liu C.¹, Zhang Z.L.^1,2, Rong C.L.³, Li X.B.⁴, Li J.¹, Cui Y.^1,2

¹College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China; ²Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China; ³The First Affiliated Hospital, Henan University of Chinese Medicine, Zhengzhou, 450000, China; ⁴College of Basic Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China

Objectives: To investigate the anti-toxicity effects and latent mechanisms of Tripterygium wilfordii Hook F (TWHF) by concocted attenuation with mung bean (Phaseolus radiates L.) in mice implanted with sarcoma S180 cells. TWHF has excellent clinical therapeutic effects but sometimes induces great hepatotoxicity and nephrotoxicity. Mung bean often prohibits drugs or food poisoning as a typical clearing away heat and toxic herbal medicine in terms of traditional Chinese medicine (TCM) theory.

Methods: Processed products of TWHF were obtained by boiling in water together with the mung bean extract until all liquid had evaporated. Raw and processed TWHF products were used for ethyl acetate refluxing extractions (EAREs). EAREs (60mg/kg) were given to mice for 14days by ig. Serum biomarkers were used for the assessment of the anti-toxicity effect, and liver and kidney tissues were assayed for the evaluation of the preliminary mechanisms.

Results: Compared with the normal group (Non-TWHF treated), TWHF caused significant elevation in biological indicators including serum alanine aminotransferase, aspartate aminotransferase, creatinine and urea nitrogen, and livers and kidneys TNF-a and lipid peroxidation (LPO) products MDA, and significant decline in tissues GSH, SOD, CAT, GST, GSH-Px and IL-10 levels. Compared with the only TWHF-treated group, the above abnormal biological parameters were all significantly reversed by processed with mung bean. Moreover, pathology analysis indicated that TWHF evoked obvious injury of hepatics and kidneys, but no obvious injury was observed in tissues from the mice treated with the mung bean-concocted product of TWHF.

Conclusions: Concocted with mung bean could exert the anti-toxicity effect on TWHF-induced hepatotoxicity and nephrotoxicity, its latent mechanisms could be at least partially involved in inhibiting oxidative stress injury and inflammation release in sarcoma S180-bearing mice.

Acknowledgements: Supported by project grants from The National Natural Science Foundation of China (Grant No. 81503269), The Program for Science & Technology Innovation Talents in Universities of Henan Province (Grant No. 16HASTIT032), The Science and Technology Innovation Talent Fund of Henan Chinese Medicine (Grant No. 2015XCXRC01), The National Science Foundation for Post-doctoral Scientists of China (Grant No. 2012M521412), and The Provincial Fundamental Research Fund in Henan University of Chinese Medicine (Grant No. 2014KYYWF-QN01).

Assessment of the Anti-inflammatory and Analgesic Activities of 70% Ethanol Extract from Houttuynia cordata Thunb. invivo

Zhang Y.Y.¹, Yu B.B.², Wang J.M.^1,2, Yu H.X.¹, Cai H.², Chen R.X.², Cui Y.^1,2

¹Henan University of Chinese Medicine, Zhengzhou, China; ²Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou, China

Objectives: To examine the anti-inflammatory and analgesic activities of 70% ethanol extract (EE) from Houttuynia cordata Thunb. (HCT) in mice, and explored the preliminary mechanisms. HCT is usually used for a traditionally heat-clearing and detoxifying medicine in terms of traditional Chinese medicine (TCM).

Methods: EE-HCT was obtained by conventional heating reflux extraction using 70% alcohol once 2h for three times with the yield about 19%. Kunming female mice were given positive drug ibuprofen (0.2g/kg) or EE-HCT (0.19, 0.57 and 1.14g/kg) for consecutive 5days by ig. The control group was given the same volume of saline. The conventional hot plate test (HPT) and acetic acid-induced abdominal writhing test (AAAWT) were used to evaluate the analgesic activity, xylene-induced ear edema test (XIET) was used for anti-inflammatory activity, and malondialdehyde (MDA) and prostaglandin (PG) E2 were assayed for evaluation of the preliminary mechanisms.

Results: Ibuprofen (0.2g/kg) and EE-HCT (1.14g/kg) significantly increased the pain threshold value in the HPT from 30 to 120min after the last administration, EE-HCT (0.57g/kg) also produced this effect from 60 to 120min, while EE-HCT (0.19g/kg) did not at any given time. Moreover, ibuprofen (0.2g/kg) or EE-HCT (0.19, 0.57 and 1.14g/kg) all significantly declined the writhing numbers of the AAAWT with the wrinkle inhibition rates of 60%, 19.5%, 27.9% and 36.5%, respectively. Besides, ibuprofen (0.2g/kg) and EE-HCT (1.14g/kg) both reduced the ear swelling degree in the XIET of mice with the swelling inhibition rates of 58.7% and 55.5%, respectively, while EE-HCT (0.19, and 0.57g/kg) did not. Further analysis demonstrated that ibuprofen (0.2g/kg) or EE-HCT (1.14g/kg) administration both significantly reduced the levels of MDA and PGE2 in mice.

Conclusion: EE-HCT could exert the anti-inflammatory and analgesic activities, and the mechanisms might be at least partially involved in prohibiting lipid peroxidation and inflammation.

Acknowledgements: Supported by project grant from The Program for Science & Technology Innovation Talents in Universities of Henan Province (Grant No. 16HASTIT032).

Chemical Constituents from Piper nigrum L. and Piper longum L. Extracted by CO2 Supercritical Fluid and Their Bioactivity on Oxygen-Glucose Deprivation in the Rat Cortical Neurons

Zhang Y.B.^1,2, Chen R.¹, Dong L.^1,4,5, Wang B.¹, Yin L.¹, Zhang Y.W.¹, Li T.T.^1,3,4,5, Fu X.Y.^1,4,5

¹School of Pharmacy, Ningxia Medical University, Yinchuan, people's Republic of China; ²School of Pharmacy, Nanjing University of Chinese Medical, Nanjing, people's Republic of China; ³Traditional Chinese Medicine School of Ningxia Medical University, Yinchuan, people's Republic of China; ⁴Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine, Yinchuan, people's Republic of China; ⁵Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education (Ningxia Medical University), Yinchuan, people's Republic of China

Objectives: In this work, we focused on CO2 supercritical fluid extraction (SCFE) fractions of Piper nigrum L. and Piper longum L. and analyzed the essential oils of SCFE fractions using GC-MS. The remaining fraction (not been identified by GC-MS) of SCFE was isolated using the column chromatography separation method. Moreover, its structure was determined using spectroscopic analysis of NMR. The biological activities of the main compounds were evaluated by MTT assay in an oxygen–glucose deprivation (OGD) induced cortical neuron injury model.

Methods: In this study, we used the SCFE to obtain Piper nigrum L. and Piper longum L. extracts, analyzed the essential oil fraction using GC-MS, and purified the chemical compounds via the column chromatography. Moreover, we screened the effects of fat-soluble components towards oxygen-glucose deprivation (OGD) in rat cortical neurons.

Results: The essential oil accounted for 3.49% of the SCFE. Furthermore, the essential profile identified 20 active compounds, with α-Caryophyllene (40.85%) being a major compound. The abundant chemical compounds of the remaining fraction were Piperine, Piperanine, Pellitorine A, Guineensine, and Pipercyclobutanamide. Compounds Piperine, Piperanine, Guineensine, Dihydropiperlonguminine had significant biological activities on the OGD model at individual doses of 1μM; and Compounds Piperamide-C9:2 (2E, 8E), Sarmentosine, Piperine, Piperanine, Piperoleine A, Piperoleine B, Pipercide, Dihydropiperlonguminine had remarkable effects at doses of 5μM. Both doses, cell survival rates were above 80%.

Conclusions: For this study, the amide alkaloids may be the main active ingredients that protect against neuronal damage in OGD model, and this finding may provide insights into the optimal chemical structure and help in studying a series of compounds that protect targets of neuronal damage.

Acknowledgements: This work was supported form the National Nature Science Foundation of China by grants (Project No. 831360666) and the Foundation of Ningxia Medical University (Project No. 2017023).

Lithium Iron Phosphate Battery Optimal Combination Methods of Electric Vehicle Based on Capacity Maximization

Xu Y., Yu L.M., Gao Q., Wang X.L., Xu W., Wu Q., Li F., Zeng X.K.

School of Automotive & Transportation Engineering, Guangdong Polytechnic Normal University, Guangzhou, Guangdong 510635, China

Background: The efficiency of electric vehicle may be affected by the consistency of electric vehicle power battery and the random combinations of batteries. It is important to arrange the batteries reasonably for improving the mileage of electric vehicle and the sustainable application of battery. The aim of this study was to establish the Lithium iron phosphate battery optimal combination methods for electric vehicle.

Methods: The analysis was based on the maximum capacity of different Lithium iron phosphate battery combinations between in series-parallel and in parallel-series. The optimal combination methods can be expressed: (1) Arranging all the capacities of battery from small to large as c1 to cn*m; (2) The ith battery can be put in the position (mod(i/m), floor(i/m)+1) (if mod(i/m)=0, mod(i/m)=m) for the series-parallel combination, and in the position (m-mod(i/m)+1, floor(i/m)+1) (if mod(i/m)=0, m-mod(i/m)+1=1) for the parallel-series combination.

Results: 12 Lithium iron phosphate batteries (5Ah) with different capacities were carried in the comparative test. The results showed that the capacities output by the method proposed were 8.3 and 9.3Ah both in the series-parallel and parallel-series combinations. And the other combinations were lower capacities (4.5, 4.2, 6.7, 6.6Ah, etal.) than the results of the methods.

Conclusion: (1) The capacities expressed formulas are different from the series-parallel combination and the parallel-series combination. (2) The optimization combination methods can be expressed by optimizing the combination matrix. (3) Test results showed that the method proposed was effective and it can improve the utilization of Lithium iron phosphate battery capacity. (4) The installation process of optimized combination should be analyzed in the next study.

Acknowledgments: The Nature Science Foundation of China (51505091), the Application of Major Program of Guangdong Province, China (2015B010135006), the science and technology planning project of Guangzhou City, China(201704020142), and the Nature Science Foundation of Guangdong Province, China (2014A030313638).

Research of Key Technology in Hip Virtual Surgery Training System and Its Program Realization

Wang M.N.

Harbin University of Science and Technology, Harbin, China

Objectives: The hip is vulnerable to invasion which has complex structure and anatomy location is deep. It requires rich experience for doctors, who want to make accurate surgical plans. Virtual surgery system can provide the virtual scene for the operation of the new doctors as well as they can get the operation skill more quickly and reduces the cost of time and fund compared to the traditional training.

Methods: The core modules of the hip surgery training system are soft tissue deformation module, collision detection module, cutting module and visualization module. Self-selection algorithm for embedded operating area was proposed in muscle deformation module of this study. This algorithm makes the scale of the tetrahedral element which is involved in calculation greatly reduced, and the speed of calculation is greatly improved without significant influence on the accuracy. Latitude and longitude collision detection algorithm was proposed in this study, the detection process can be accelerated by the search algorithm. First, the 3D information of triangular patch was transformed to latitude and longitude information. Then, the latitude and longitude data structure of independent design was used to complete collision detection and update operation. Cutting algorithm of transient display and delay processing was proposed in this paper. To ensure the subsequent finite element calculation can be kept stable and efficient, a path separation scheme is proposed and does not use the tetrahedral element subdivision scheme.

Results: Compared with the muscle deformation module without the use of the Self-selection algorithm, the acceleration algorithm of this paper improves the speed of deformation calculation by 30 times, but the accuracy is the original 70%. The detection and update operation of Latitude and longitude collision detection algorithm more efficient contrast with traditional bounding box collision detection algorithm. The cutting display frequency is very stable of the proposed cutting algorithm and meets the requirements of the cutting module of the virtual surgery system.

Conclusions: The key technologies in hip virtual surgery training system were solved. The program is stable and efficient.

Acknowledgements: This research was supported by NSFC (No. 61572159), Scientific Research Foundation for the Returned Overseas Scholars of Heilongjiang Province and Harbin University of Science and Technology Youth Talent Support Program.

Gradually Decreasing Photoperiod Increases Cellular but Not Innate Immunity in Siberian Hamsters (Phodopus sungorus)

Tian Y.F.¹, Zhao H.S.², Xu D.L.², Hu X.K.², Zhao M.F.², Zhang Q.Q.², Zhao Q.Z.², Zhang Y.Q.², Zhang Q.L.², Li Z.Y.², Wang Y.²

¹Library, Qufu Normal University, Qufu, China; ²School of Life Sciences, Qufu Normal University, Qufu, China

Background: Photoperiod is an important environmental cue for animals to time the year. The winter immunocompetence enhancement hypothesis postulates that animals in the temperate area would actively increase immune responses to offset the negative effect of stressful conditions in winter (i.e., low temperature and food shortage etc.). In order to test this hypothesis, we mimicked the transition from summer to winter by decreasing photoperiod gradually and investigated the changes of immune function in Siberian hamsters (Phodopus sungorus).

Method: Twenty two female adult hamsters were randomly assigned into the control (12h light:12h dark, Control, n=11) and the gradually decreasing photoperiod group (Experiment, n=11), in which day length was decreased from 12:12h light-dark cycle to 8:16h light-dark cycle at the pace of half an hour per week.

Results: Body composition (wet carcass mass, subcutaneous, retroperitoneal, mesenteric and total body fat mass) and the masses of the organs detected such as brain, heart, liver and so on were all not influenced by gradually decreasing photoperiod. Similarly, immunological parameters including immune organs (thymus and spleen), white blood cells and serum bacteria killing capacity indicative of innate immunity were also not affected by gradually decreasing photoperiod, which did not support the winter immunocompetence enhancement hypothesis. However, phytohaemagglutinin response after 24h of PHA injection was increased by gradually decreasing photoperiod, which supported this hypothesis. There was no correlation between cellular, innate immunity and body fat mass, suggesting that body fat could not explain the changes of cellular immunity.

Conclusion: In summary, distinct components of immune system respond to gradually decreasing photoperiod differently in Siberian hamsters.

Acknowledgments: Supported by the National Natural Science Foundation of China (31370427; 31370444)

Spine Date Seed Decoction Administration Ameliorates Anxiety and Depression in Mice

Li X.B.¹, Li Y.J.¹, Zhao X.¹, Bao S.T.¹, Gao X.L.¹, Li N.², Wang J.M.¹, Xie Z.L.¹, Liu X.H.¹, Zhang Y.T.³, Ding Y.W.¹

¹Henan University of Chinese Medicine, Zhengzhou, China; ²The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China; ³ Guangzhou University of Chinese Medicine, Guangzhou, China

Objectives: Spine Date Seed Decoction (SDSD) is a traditional Chinese herbal formula. The present study investigates the antidepressant-like effect of SDSD and its possible mechanism in mice

Methods: The depression model was established by unpredictable chronic mild stress (UCMS) for 28days. Mice were given SDSD, paroxetine, or an equivalent volume of saline for 21days. The antidepressant-like effect of SDSD in mice was investigated by using the forced swim test (FST), the tail suspension test (TST) and the open field-test (OFT). The levels of corticosterone level in plasma, 5-hydroxytryptamine (5-HT) in the hippocampus, the cortisol (CORT) in the adrenal gland were examined by ELISA.

Results: SDSD administration significantly reduced the immobility time in both the FST and the TST without changing locomotion OFT. SDSD also reversed UCMS-induced increases in corticosterone in plasma. Besides, after the treatment, the adrenal gland CORT levels in the SDSD intervention groups were notably down-regulated, and hippocampal 5-HT evidently up-regulated in SDSD intervention groups.

Conclusion: SDSD significantly improved depression-like behaviors in UCMS mice and its antidepressant actions might be related with, at least in part, by up-regulating hippocampal 5-HT, in down-regulating adrenal CORT and plasma corticosterone levels.

Acknowledgments: Supported by a project grant from The National Natural Science Foundation of China (Grand No. 81603527),Science and technology project of Henan Province(Grand No. 162102310466),Key scientific research projects of Henan Province Colleges and universities(Grand No. 16A360010),Henan University of Traditional Chinese Medicine Scientific and technological innovation talent support program(Grand No. 2015XCXRC05). Science and technology project of Zhengzhou City(Grand No. 20150310)

Effects of Temperature on Photosynthetic Physioecology of Torreya fargesii Seedlings

Zhou X.R., Shang J., Li N., Jiang B., Wang J.H.

School of Life Science and Biotechnology, Yangtze Normal University, Fuling, China

Objectives: Torreya fargesii Franch. is an endangered species of Taxaceae, which is endemic to China. It is a very important forest resource, with high medicinal value and industrial use. As a result of excessively cut for utilizing, as well as difficulties in natural regeneration, its resources serious decline, so artificial cultivation has become an effective way for conservation and sustainable utilization of T.fargesii. In this study, temperature stress was simulated by artificial climate box, and the photosynthetic characteristics were analyzed to determine the appropriate environmental conditions of seedlings growth of T.fargesii.

Methods: Three different temperature conditions were controlled by artificial climate boxes, namely low-temperature treatment (10°C/16°C), medium-temperature treatment (18°C/24°C), high-temperature treatment (26°C/32°C), and the physiologic indexes of T.fargesii seedlings were determined under different photosynthetic active radiation (PAR) and CO2 concentrations by portable photosynthetic apparatus.

Results: The net photosynthetic rate (Pn) and light saturation point (LSP) of medium-temperature treatment was higher than that of other temperature treatments, and the light compensation point (LCP) was on the contrary. When PAR was 1000μmol/m²/s, the Pn of T.fargesii seedlings reached maximum value. When CO2 concentration was 900μmol/mol, the Pn of T.fargesii seedlings was the highest. Furthermore, stomatal conductance (Gs), transpiration rate (Tr) and intercellular CO2 concentration (Ci) were interacted by temperature, PAR and CO2 concentration.

Conclusions: The average temperature about 21°C (18/24°C), PAR of 1000μmol/m²/s and CO2 concentration of 900μmol/mol were the suitable cultivation conditions of T.fargesii seedlings.

Acknowledgements: Supported by the National Natural Science Foundation of China (Grand No. 31470568).

Impact of LED lighting on Photosynthetic Indices of Plant

Duan R.^1,2, Yang C.Y.¹, Su J.F.³

¹Faculty of Arts, Chongqing Technology and Business University, Chongqing 400067, China; ²School of architecture and urban planning, Chongqing University, Chongqing 4000030, China; ³Chongqing Key Laboratory of Electronic Commerce & Supply Chain System, Chongqing Technology and Business University, Chongqing 4000067, China

Objectives: Due to the lack of lighting standards for landscape plants, garden plant lighting is still out-of-order in China. Lighting and plant growth are tightly connected. Light intensity, spectral energy distribution and illumination duration are all the influence factors for the growth of plants. As artificial light are different from the sunlight, the addition of artificial illumination to plant impacts the photosynthesis and photosynthetically active radiation of garden plants.

Methods: We used five nightscape light spectrum to illuminate the garden plant, and three light intensities for each spectrum, which are 1000lux, 1500lux and 2000lux. Meanwhile, a reference group was set up, which was irradiated only by sunlight, without artificial illumination. Plants were illuminated according to the landscape lighting time in China, which was 6:30pm–10:00pm. Measured the photosynthetic indexes of the plant and photosynthetically active radiation under the artificial light. Contrast that value with that goes under the sunlight.

Results: The results showed that: (1) At the same light intensity, photosynthetically active radiation of plant was far higher than that under the LED. (2) Under LED, net photosynthetic rate of plant rose with enhancing light intensity. (3) Under green LED light (530nm), photosynthetically active radiation of plant increased with enhancing light intensity. However, net photosynthetic rate remained negative all along.

Conclusions: The present study demonstrated that LED light sources have a significant influence on the photosynthetic indices and photosynthetically active radiation of plant.

Acknowledgements: The National Natural Science Foundation of China; Number: 51478060.

Effects of Exogenous Ethanol on Germination and Seedling Growth of Brassica Napus L.

Zhao Y.¹, Tang Q.Y.¹, Chen L.M.², Yang Q.S.³, Wang B.J.¹

¹College of Science, Yunnan Agricultural University, Kunming 650201, China; ²Biotechnology Research Center, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China; ³School of Ethnic Medicine, Yunnan Minzu University, Kunming 650500, China

Background: Many organic compounds including alcohols are known to have dormancy breaking effect on seeds of many species. Ethanol is a product of anaerobic metabolism that is a low molecular weight alcohols, plays a key a role in many important events, such as allow tissue to survive transient periods of oxygen stress by supplying ATP, and stimulating germination of seeds of some plant species.

Methods: Seeds of Brassica Napus L. were treated with ethanol for different concentrations (0, 10, 50, 100, 200, 500, 1000 and 2000mM) along with control to determine the optimal treatment concentration and find out the best growing condition. The harvest leaves were ground into a fine powder in liquid nitrogen, and chlorophyll (Chl), the H2O2 content and MDA content was determined.

Results: Ethanol treatment caused clear increases in germination rate, germination potential, germination index and Vigor index compared to the control. The highest seed germination and seedling growth were obtained by treated with 50mM ethanol. Physiological experiment results indicated that treated with ethanol significantly reduced the leaf H2O2 and MDA (Malondialdehyde) content and increased leaf chlorophyll content, thus improved the photosynthesis and promoting the plant growth.

Conclusion: This study confirmed that ethanol treatment stimulated the Brassica napus L. seeds germination and seedling growth. Responses were higher in germination observed with 50mM ethanol compared with the control. Moreover, ethanol treatment decreased H2O2 and MDA content, enhanced leaf chlorophyll content which were responsible for improving germination of Brassica napus L. seeds.

Acknowledgments: Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province (No. 2015FB147), National Natural Science Foundation of China (31460137) and Yunnan Agricultural University Natural Science Foundation for Young Scientists Project (2015ZR15).

The Study of Brain Tumor Accurate Border Segmentation and Location Based on DTI

Zhou Z.Z.¹, Chen G.X.¹, Hu M.C.¹, Dong M.¹, Liu J.W.²

¹Medical image School of Mudanjiang Medical University, Mudanjiang, China; ²School of Pharmacy, Mudanjiang Medical University, Mudanjiang, China

Objectives: Three-dimensional model of brain combining with fMRI-DTI localization technology provides a new research method for brain tumor segmentation, and this fusion technology can be used to identify brain tumor location and it is peripheral functional areas effectively, rapidly and accurately. The aims of this project are help to divide and locate the brain tumor boundary and evaluate the tumor shape and volume.

Methods: fMRI and DTI experiments were designed for 20 volunteers. Reconstructed DTI three-dimensional brain image was used to display white matter fiber bundle direction and spatial distribution. The brain tumors and their surrounding white matter fiber bundle MRI and DTI images of 20 brain tumor patients were done respectively. Finally, the static brain tumor model was integrated with fMRI-DTI image and dynamic brain tumor model was established successfully. The fusion algorithm was based on the curve integral method under the finite element frame.

Results: For fMRI, MRI and DTI data fusion, the DTI reconstruction fiber bundle image was matched with brain tumor MRI images first, and then, the image transformation was implemented and DTI data registration to standard anatomical data was made. After fiber tracing and three-dimensional reconstruction, the fiber reconstruction was finally completed.

Conclusions: The three-dimensional model of brain tumor integrated with fMRI-DTI technology can effective, fast, accurate discriminate brain tumor nature, divide brain tumor boundary and less affect surrounding functional areas. It is an very important and worth promoting technology for clinical delicate brain tumor surgery.

Acknowledgement: Supported by a project grant from the national natural science foundation of Heilongjiang Province (Grand No. H2015082).

Intelligent Wheelchair Robot Based on Vision Navigation

Jiao J.^1,2, Zheng X.J.^1,2

¹Chongqing Creation Vocational College, Chongqing, China; ²Chongqing Engineering Research Center of Industrial Robots Application Service, Chongqing, China

Objectives: With the development of artificial intelligence and robot technology, intelligent wheelchair becomes the best choice for assistive devices of the elderly and disabled people. Vision based mobile robot navigation is an advanced navigation technology developed in recent years. Compared with other non- visual sensor navigation, it has many remarkable advantages such as rich information, wide detection range and complete target information, etc. Visual navigation wheelchair robot can better help users to improve their freedom and quality of life.

Methods: The paper focuses on navigation method of intelligent wheelchair robot based on visual information. Firstly, the location information of obstacles in complex environment is extracted, and the movement trend of obstacles is predicted by Kalman filtering algorithm. Then, the predictive feedback multidimensional planning is carried out, including the tracking state and the corrective feedback. Finally, the navigation function of the intelligent wheelchair robot is realized by the directional movement and obstacle avoidance.

Results: The method combines obstacle position calibration and motion prediction, through processing analysis path planning, make motion decisions autonomously, and guide wheelchair robot to reach the target position safely.

Conclusions: Visual navigation can be applied to auxiliary driving, it also can be applied to robot vision navigation products.

The Genome Sequence Compression Based on Distributed Source Coding with 2-D Images

Wang F.Y.¹, Chen M.^2,3

¹Information Technology College, Kunming University, Kunming, Yunnan 650243, China; ²Information College, Yunnan University, Kunming, Yunnan, 650091, China; ³Information Security College, Yunnan Police College, Kunming, Yunnan 650223, China

Background: The predecessors focus on enhancing the compression efficiency of genome sequences during the past two decades. There are three existing types of compression algorithm to satisfy the requirements of the genome sequences compression. The first type is the substitutional algorithms based on Lz77, which rely on the detection and mapping those repetitive fragments containing in a whole genome sequence. However, for these un-repetitive fragments, this algorithm cannot achieve a high compression performance. Another type of genome sequence compression algorithm is referred to as the referential algorithm. With the excellent cooperation with the rapid DNA sequencing technology, this algorithm can achieve unprecedented compression results for Human genome sequence, but for those simple genome sequences which contain little repetitive fragments, it cannot work well. For these un-repetitive fragments, the entropy coding scheme based on the context weighting is suggested to enhance the corresponding compression efficiency in past researches. The performance of the context weighting is depending to the value of weights. However, the optimization of weights is not discussed any more before, although in some algorithms, their corresponding weights are calculated by using some various methods, such as filters or empirical equations. Their methods do not optimize the weights directly in fact. Therefore, the weights optimization is one important creative ideal in this paper.

Methods: The paper aims to tackle two problems. One is the optimization method for context weighting, another is its application on the compression of the un-repetitive fragment of genome sequence. According to the description length theory, the description length of a counting vector can describe the coding complexity when this counting vector is used to estimate the corresponding probability distribution which will be drive the arithmetic encoder. If the description length is small, the coding results will be better. In essence, the context weighting operation is to merge some counting vectors into one proportionally by using the given weights. In this case, the description length of the counting vector weighted is equivalent to the weighting of the description lengths of counting vectors participated into weighting. When this linear equivalence is obtained, some linear optimization method, such as Least Square algorithm, can be employed to optimize the weights. Then the optimized context weighting algorithm is utilized to improve the compression efficiency of the un-repetitive fragment of genome sequences, which can obtain better results than other existing algorithms.

Results: Firstly, the performance of the proposed optimized context weighting is testified by using a lot of experiments. The results indicate that the proposed method can obtain weights which leads to the minimum description length of counting vector weighted. Then ten benchmark genome sequences, including VACCG, CHNTXX etc, which contain little repetitive fragments respectively are compressed by using the compression algorithm based on the optimized context weighting. Finally, the compression radios of 6 genome sequences are better than the respective results from other existing genome sequence compression methods. The average coding results is enhanced almost 7% than any other existing algorithms.

Conclusion: The optimized context weighting can optimize the weights directly under the description length theory and the compression efficiency can be enhanced when it is used to compress the un-repetitive fragment of genome sequence. The design objective is achieved.

Acknowledgments: The Natural Science Foundation of Yunnan; Foundation Number: 2016FB113.

Compressed Sensing of High Frequency Channel for Mobile OFDM Systems in Emergency Medical Rescue

Wang K.^1,2, Liu J.Z.¹, Gan Z.C.², Li G.J.¹

¹Communication Sergeant Institute, PLA Army Engineering University, Chongqing 400035, China; ²Information communication Institute, National University of Defense Technology, Wuhan, Hubei 430010, China

Background: In the emergency medical rescue of public emergencies such as natural disasters, safety accidents, and health risks, communication and information transfer often need to be carried out when the usual means of communication fails. The High Frequency (HF) OFDM is one of the most important methods of communication in emergency medical rescue because of its flexibility, easy to set up and free of network hub and active relay. To exploit these technical advantages, the accuracy of channel state information (CSI) is crucial. However, the acquisition of the CSI of the doubly-selective (DS) channels for HF OFDM systems requires a large amount of spectrum and time resources, which leads the reduction of spectral efficiency and communication reliability. Therefore, an efficient channel estimation method for HF OFDM systems becomes the key to improve the performance of communication in emergency medical rescue.

Methods: In this paper, a new channel estimation scheme based on compressed sensing (CS) is proposed for high-mobility HF OFDM systems to reduce the pilot overhead. Specifically, by exploiting the sparsity of OFDM channel in basis expansion model (BEM), we theoretically verify that the BEM coefficient corresponding successive OFDM symbols also share a common support. To utilize this temporal correlation of BEM coefficients, a new reconstruction algorithm is proposed to improve the present estimation by prior channel information from previous estimation. Finally, an optimal pilot placement scheme is proposed based on deterministic measurement theory to further improve the performance of channel estimation.

Results: By utilizing the prior information of sparsity about the HF channel, the reconstruction of channel coefficients achieves higher accuracy than exiting algorithms. A deterministic measurement matrix is introduced by the proposed optimal pilot placement scheme, and the measurement performance is improved by further reducing the coherence of columns.

Conclusion: The proposed channel estimation scheme outperforms the conventional CS-based scheme in terms of both estimation accuracy and spectral efficiency.

Acknowledgments: The Natural Science Foundation of China (Grant: 61271251); The Program for New Century Excellent Talents in University (Grant: NCET -11 - 0873).

Metabolic Spatio-temporal Simulation Research of Urban Complex Water Circulation System: Based on Dual Coupling Perspective

Xu J.^1,2, Li B.K.¹, Yu Z.H.^1,2

¹School of Management, Tianjin University of Technology, Tianjin, China; ²School of Environmental Science and Engineering, Tianjin University, Tianjin, China

Objectives: Water environment pollution has a great negative impact on human health, here from the perspective of water quality and quantity reveal the microcirculation change process of water environment circulation metabolism, attempts to formulate more precise water environment regulation and control measures based on this process to reduce the harm of water environment pollution to human health.

Methods: This paper focuses on the design and implementation of spatial and temporal simulation model of water quality and quantity coupling metabolism in urban complex water cycle system based on SD and GIS technology, and the target city is used as a case to verify and improve the model. The process of coupling and metabolic process of water quality and quantity in urban complex water circulation system is analyzed in detail, and the process of coupling and metabolic evolution of water quality and quantity in the urban complex water circulation system is clarified, constructing spatio-temporal dynamics models and realizing the spatio-temporal simulation of metabolic processes.

Results: The model mainly includes three modules: the basic data module, the information interaction module and the basic model module, finally realizing the basic functional coupling and simulation. It is verified that this model can analyze in detail the operation conditions of the metabolic process of the urban complex water circulation system, and caused by the main reason for the imbalance of water metabolism.

Conclusion: Through this model, the health status of the target urban water environment can be grasped and the water environment precise regulation and control measures can be formulated to ensure the health of urban residents.

Acknowledgments: Supported by the projects grant from the Opening Foundation of Tianjin University State Key Laboratory of Hydraulic Engineering Simulation & Safety (Grant No. HESS-1701); Major Projects of Science and Technology in Tianjin (Grant No. 16ZXFWGX00090); Major Projects of Science and Technology in Tianjin (Grant No. 15ZXHLSF00040); the Opening Foundation of Tianjin University State Key Laboratory of Hydraulic Engineering Simulation & Safety (Grant No. HESS-1511); Humanities and Social Science Foundation of the Ministry of Education of China (Grant No. 14YJC630211); National Social Science Foundation Project (Grant No. 15BGL173).

Internal Jugular Vein Catheterization Induced Superior Vena Cava Obstruction with Azygos Vein Compensatory Dilatation

Chen Y.W., Shi W.J., Tao X.C., Zhang P.

Department of nephrology, PLA 254th Hospital, Tianjin, China

Objectives: Internal jugular vein catheters are frequently used as a vascular access in maintenance hemodialysis(MHD) patients. It has become a real challenge to give the successful creation and maintenance of reliable vascular access to increasing number of elderly MHD patients.

Methods: A 78-year-old woman with chronic renal failure was admitted. She has symptoms of the superior vena cava syndrome(SVCS). As a consequence of central venous obstruction caused abnormal flow in internal jugular vein catheters, venous hypertension made it impossible to conduct dialysis. The patient had been hemodialysed since November 2013. Her medical history revealed significant difficulties in permanent vascular access creation. In October 2013, an arteriovenous fistula(AVF) was created in her right forearm. After six months, the fistula developed thrombosis. The proper flow could not be obtained by the performed thrombectomy. A temporary vein catheter was placed in right internal jugular vein in May 2014. Then there was a failed attempt of creating a permanent AVF in the cubital fossa. After one week, she had to receive a permanent internal jugular vein catheter. The history and the patient's symptoms at admission suggested central venous obstruction, therefore the decision to perform venography was made. The examination revealed the fibrous glisson around the catheter and completely occlusion of the superior vena cava(SVC) with significant collateral circulation. The azygos vein was compensatory expanded with a diameter of about 16cm, which was much wider than its own diameter. Further examination indicated that the blood could afflux into inferior vena cava through azygos vein, which partly improved the venous drainage.

Results: Due to the high risk of the stent crossed the lumen of the SVC, it was decided to place a permanent catheter in the right femoral vein. The angiography showed the permanent catheter patency and then the internal jugular vein catheter was removed.

Conclusion: With the development of central venous catheter (CVC) indwelling technique for hemodialysis CVC-induced central vein disease(CVD) has been emphasized in clinical practice. Insertion of CVC has the drawback of causing vein stenosis and upper extremity edema with blood recirculation in the ipsilateral limb. CVD is believed to be induced by focal endothelial denudation from catheter insertion and following chronic irritation. When patient's clinical examination and history indicate a high probability of CVD, venography should be performed to confirm its presence and exact degree. It is simple, easily available and time and cost effective. To get adequate blood flow in vascular access, every effort must be made. The “AVF first” approach combined with implantation and surveillance of dialysis catheters is crucial among the dialysis population.

Research on H Acid Wastewater Pretreatment Technology in Pharmaceutical Industry

Li M.T.¹, Xu J.², Yu Z.H.^2,3, Li B.K.³

¹School of Chemical Engineering and Technology, Tianjin University, Tianjin, China; ²School of Environmental Science and Engineering, Tianjin University, Tianjin, China; ³School of Management, Tianjin University of Technology, Tianjin, China

Objectives: H acid as one of the important raw materials in the pharmaceutical industry, a large number of applications in the pharmaceutical industry at the same time, due to its strong biological toxicity and high liquidity in the water environment, once discharged directly without treatment, it is easy to cause serious water pollution and serious harm to the human body.

Methods: Focus on the design and implementation of pharmaceutical industry H acid wastewater pretreatment technology based on complexation extraction method. The main components of H acid wastewater from the pharmaceutical industry were analyzed in detail. According to the results of the analysis, it was determined that the wastewater was pretreated in the tank extractor by using TOA as the complexing agent and kerosene as the diluent, and the effects of H acid wastewater treatment under different extraction conditions were studied.

Results: Using complex extraction technology to treat H acid wastewater, the optimum process conditions determined by the tests are as follows: influent COD 40,000˜45,000mg/L, pH 1, temperature 40°C, the volume ratio of extraction agent and wastewater 1:1, the volume ratio of loading extraction agent and renewable agent 50:1, stirring time of 5min, 30% mass fraction of regenerative agent. Under these conditions, the COD removal rate is above 98%. COD concentration in the raffinate can be limited to about 500mg/L. The used extractant can be reused after regeneration.

Conclusion: The pretreatment technology has the advantages of remarkable effect, stability, lower processing cost and provided a reliable guarantee for engineering application.

Acknowledgments: Supported by the projects grant from the Opening Foundation of Tianjin University State Key Laboratory of Hydraulic Engineering Simulation & Safety (Grant No. HESS-1701); Humanities and Social Science Foundation of the Ministry of Education of China (Grant No, 14YJC630211); Tianjin science and technology major projects and projects (Grant No. 16YFXTSF00270); Tianjin science and technology plan project(Grant No. 16ZXFWGX00090).

Antidepressant-like Effects of Yueju Baohe Dihuang Decoction in a Rats Model of Chronic Unpredictable Mild Stress

Li X.B.¹, Yin D.H.², Li Y.M.³, Wu Y.C.³, Zhang D.Y.³, Yu M.Z.³, Chai L.L.³, Zheng L.K.³, Ma C.C.³, Li T.T.³, Wang H.H.³, Li J.M.³, Ma S.³

¹Henan University of Chinese Medicine, Zhengzhou, China; ²The First school of clinical medicine of Henan University of Traditional Chinese Medicine, Zhengzhou, China; ³The Second school of clinical medicine of Henan University of Traditional Chinese Medicine, Zhengzhou, China

Objectives: The present study was to investigate the antidepressant-like effect of Yueju Baohe Dihuang decoction (YBD) and its relevant mechanisms on depression rates.

Methods: Rats with depressive-like behavior induced by chronic unpredictable mild stress(c*ms). All rats were randomly divided into four groups, normal group, model group, fluoxetine group and YBD group. The YBD group was given YBD by gavage. The antidepressant-like effect of YBD in rats was investigated by using the body weight,tail suspension test,sucrose preference test and forced swimming test. Besides, the serum NE was test by ELISA.

Results: The results demonstrated that compared with the normal group, the body weight of the model group was declined evidently. Meanwhile, the body weight of the YBD group and the fluoxetine group was increased. c*ms caused a significant decrease in sucrose preference of rats and increased immobility duration in the forced swim test and tail suspension test and these depression-like behaviors were significantly improved by YBD. Besides, the YBD group had higher NE concentrations in peripheral blood than the model group.

Conclusions: YBD significantly improved depression-like behaviors in c*ms rats and its antidepressant actions might be related with, at least in part, by up-regulating NE concentrations in peripheral blood.

Design of Mobile Learning Course of College Medical English on Vocabulary and Terms Based on WeChat Platform

Wu J.¹, Yu S.M.², Zhao Y.³, Wang L.J.³

¹Jilin University of Finance and Economics, Changchun, Jilin, China; ²Changchun Automobile Economic and Technological Development Zone Experimental School, Changchun, China; ³Changchun First Experimental Yin He Primary School, Changchun, China

Objectives: At present, the teaching of medical English in Chinese colleges and universities is facing a severe challenge. Professional courses take up a lot of time for students to study, and the complexity and boring of medical vocabulary and terms are killing students’ interest in learning. As a new instant messaging product, WeChat is deeply loved by Chinese College Students and its technology and functions are also very mature. Therefore, the research will take Wechat as a platform to promote the study of medical English, especially vocabulary and medical terms.

Methods: This mobile course begins with the establishment of a specific Wechat Official Account, and then the researchers will create some specific functional module. The learning resources selected by teachers should be lively and interesting, which should contain video, audio, pictures, and text resources, etc.. For instance, it could choose an operation video with English explanation. And it could also contain a module which use direction of drugs to show students the word formation of medical vocabulary. And then, the resources are issued to students with WeChat's group push function. Students can use their mobile phones as terminal devices to receive the resources and study flexibly according to their actual conditions. In addition, researchers will create a platform for students to communicate medical experience in English by using Wechat's function of post and voice communication. The students can get the guidance of the teachers in time and solve the difficulties in the medical English study and medical papers reading quickly.

Results: With the help of the new platform of WeChat, the teaching information and teaching resources can be transferred to the learners point to point. Learners can choose the resources to study according to their own actual problems and make their study time more reasonable.

Conclusions: The medical English mobile course based on the WeChat platform can break the limitations of a single classroom education and play a greater role in the field of medical English learning. Therefore, it could improve the Chinese students’ international communication of medicine.

The Application of Computational Fluid Dynamics in Diagnosis and Treatment of Cerebral Aneurysm

Sun D.W.

College of Physics and Electronic Information, Inner Mongolia University for the Nationalities, Tongliao, The Inner Mongolia Autonomous Region, 028000, China

Background: Aneurysmal subarachnoid hemorrhage(aSAH) caused by ruptured cerebral aneurysm is a disease that is harmful to health. The annual incidence is 0.009%–0.020%. Its high mortality and disability rate is one of the difficult problems for clinicians. The mortality rate of aSAH was 34%, and the severe disability rate was 17%. Therefore, it is necessary to assess the risk of aneurysm rupture before operation. The academic community agrees that the hemodynamic environment in the aneurysm is closely related to its occurrence, growth and rupture.

Methods: The effects of metal coverage and cross section design on hemodynamics in the aneurysm were studied by the ideal model. The simulated stent implantation in the aneurysm process provides the basis for the formulation of the best treatment for the preoperative operation of complex aneurysms. The images and blood flow data before and after the operation of the patients were used to establish a personalized model for different patients in different periods.

Results: The increase of inflow angle, the increase of blood flow load at the top of aneurysm, the concentration of shock area, the emergence of multiple vortices, the increase of energy loss, the change of WSS and the increase of pressure on vascular surface lead to the destruction of vascular endothelium and eventually the rupture of cerebral aneurysm. It is necessary to establish a unified standard of hemodynamic parameters and to carry out multifactor analysis of fluid mechanics with larger sample size.

Conclusion: Through the close cooperation of scientists and biomechanical neurosurgeons, preoperative embolization of cerebral aneurysms in numerical simulation, prediction of the operation risk, develop personalized surgical will become possible.

Acknowledgments: The National Natural Science Foundation of The Inner Mongolia Autonomous Region; Foundation Number: 2017BS0105.

The Influence from Microcirculation Load Based on Numerical Simulation of Fluid–Solid Coupling of Aorta

Sun D.W.

College of Physics and Electronic Information, Inner Mongolia University for the Nationalities, Tongliao, The Inner Mongolia Autonomous Region, 028000, China

Background: The construction of a reasonable numerical model is very important for the study of hemodynamics. In the current study of hemodynamics, fewer studies consider the impact of microcirculation load. If the problem of research involves the adjustment process of the whole circulation system of the human body, the ideal result can be obtained only by considering the microcirculation load.

Methods: The fluid – solid – microcirculation load coupled hemodynamic model is constructed. The influence of microcirculation load on the model was studied, and the change of pressure in the pipeline was analyzed, the effects and status of microcirculatory load on microcirculatory system and the coupling form between the main parts of the blood circulation are discussed.

Results: After the increase of the microcirculation resistance, the power required for the flow field is also increased, and the range of pressure oscillations in the pipe increases. When the tube wall is hardened, the diastolic pressure decreases and the systolic pressure increases. Because of the decrease of blood vessel wall compliance, the heart needs more power to input blood into the blood vessel, but the resistance of the microcirculation load has not increased, so the diastolic blood pressure has decreased.

Conclusion: The model considering the microcirculation load can be more reasonable to simulate the physiological characteristics of blood flow in the blood vessels. It provides the theoretical basis and technical means for the clinical treatment of cardiovascular and cerebrovascular diseases.

Acknowledgments: The Scientific Research Foundation of Inner Mongolia University for Nationality; Foundation Number: NMDYB1782.

Analysis of the Effect of Physiological Activity of Cervical Vertebra on the Hemodynamics of Vertebral Artery by Fluid-structure Coupling Method

Sun D.W.

College of Physics and Electronic Information, Inner Mongolia University for the Nationalities, Tongliao, The Inner Mongolia Autonomous Region 028000, China

Background: The unique anatomical structure and physiological characteristics between the cervical vertebra and the vertebral artery(VA) make the biomechanical mechanism of the region complex and changeable. Limited to inspection conditions, the biomechanical relationship between cervical vertebra and VA is difficult to obtain by ultrasonic examination.

Methods: Based on the normal human cervical vertebra (C0-T1) and the three-dimensional finite element model of bilateral vertebral artery, Simulated cervical spine flexion, extension, left and right lateral bending, left and right rotation, to observe the effect of cervical movement on the stress of VA vascular wall, and to calculate hemodynamic parameters through fluid-structure coupling interaction between vessel wall and fluid.

Results: In the process of cervical vertebra activity, the maximum strain of the vessel wall is most obvious in the extension and lateral bending, and the strain ratio is 23.04% and 35.5%, respectively. With respect to the activity of cervical vertebra, the minimum flow rate was almost 30%–40% in the range of physiological activity. During the flexion and extension of the cervical spine, the velocity - time curve of bilateral VA was similar, and in 0.5 s. When lateral bending of the cervical spine, the wave peak and the valley of the ipsilateral VA appeared earlier than the contralateral VA, When the cervical spine rotates, the wave peak and the valley of the ipsilateral VA appear later than the contralateral VA.

Conclusion: The stress characteristics and blood flow-time variation curves of bilateral VA vessels can be verified with other experimental results, and can explain clinical phenomena reasonably. The established VA model will provide an ideal platform for the research of VA related diseases.

Acknowledgments: The National Natural Science Foundation of The Inner Mongolia Autonomous Region; Foundation Number: 2017BS0105.

Study of Urodynamics in SUI Patients Based on Fluid-structure Coupling Model

Sun D.W.

College of Physics and Electronic Information, Inner Mongolia University for the Nationalities, Tongliao, The Inner Mongolia Autonomous Region, 028000, China

Background: The existing fluid dynamics simulation method is confined to two dimensional rigid models, which fail to consider the complexity of pelvic floor structure, especially the interaction between urine and soft tissue.

Methods: This paper adopts the method of computational fluid dynamics for SUI disease, established coupled dynamic model of urinary system between urine and soft tissue, through strain analysis of soft tissue structures. By analyzing the strain, stress and deformation of the soft tissue structure and the pressure field and velocity field distribution of the urine flow in the urinary system, we explain the mechanical mechanism of the opening and closing process of the urinary system.

Results: The pressure distribution of the main characteristic points of the urine flow field is wavy change with time, and the pressure of the bladder is not always higher than the pressure of the urethra. It is possible to open or close the urinary tract system from the urodynamic point of view under the condition that the urinary tract system has a certain abdominal pressure environment.

Conclusion: By analyzing the strain, stress and deformation of the soft tissue structure, and the pressure and velocity distribution of urine flow in the urinary tract system, From the bladder neck displacement, urethral pressure and other factors, we explained the mechanical mechanism of SUI disease, and provided theoretical basis and technical analysis hand for surgical treatment of SUI disease.

Acknowledgments: The National Natural Science Foundation of The Inner Mongolia Autonomous Region; Foundation Number: 2017BS0105

Study of Access Technique for Linked Life Data

Zhang H.F.^1,2, Gu L.P.¹, Qiu J.L.^1,3

¹School of Computer and Information Engineering, Nantong Institute of Technology, Nantong, China; ²School of Computer and Information, Hohai University, Nanjing, China; ³School of Computer Science and Technology, Nantong University, Nantong, China

Objectives: Linked Life Data has integrated all the public semantic data in the field of life science and medicine that can be obtained almost to date, including UniProt, PubMed, EntrezGene and so on. LLD is currently being accessed through the SPARQL End Point to provide query and reasoning services for various life and medical application systems. The aim of study is to construct the query system to access Linked Life Data(LLD).

Methods: The system creates a class hierarchy of visual LLD ontology for users, and allows users to define query conditions through simple operations based form. After the user completes the definition of the query condition, the system can generate corresponding SPARQL statements automatically, and then submit queries to LLD through the common SPARQL End Point over the LLD dataset. The design of this system is divided into four steps:(1) Ontology Parsing: by parsing the ontology, all the classes in the LLD ontology are obtained, and then an ontology class hierarchy is created on the system interface for users to browse;(2) Query Specifying: with the help of simple HTML forms, users can easily specify the required query conditions;(3) SPARQL Generation: automatically generate the corresponding SPARQL statements based on the specified condition query;(4) Query Execution: by calling the public LLD SPARQL End Point, the SPARQL query statements that are automatically generated or manually edited is executed to return the result of the query that can be a different RDF serialization format.

Results: The following functions can be realized by this system: (1) The description of specific genes (such as insulin receptor genes) in the gene noumenon can be queried;(2) The gene description on a specific chromosome (such as the human “Y” chromosome) can be queried; (3) The sequence name of a specific protein (uniprot-protein: P06213) and the name of the enzyme can be queried; (4) Drugs related to a specific molecular interaction protein related to a specific disease can be queried.

Conclusions: The approach to query LLD shown in experiments and implements is very useful for users to access LLD data easily. This method is feasible using the Java language and the Apache Jena framework for Java.

Acknowledgements: Supported by the scientific research backbone training project of Nantong Institute of Technology; the Universities Natural Science Research Project of Jiangsu Province under Grant No. 17KJB520031; the team for science & technology and local development service of Nantong Institute of Technology.

Genome Compression Based on 2-D Mapping with Context Modeling Entropy Coding Scheme

Bu C.F.¹, Zhe M.W.², Chen M.³

¹Department of physical science and technology, Kunming University; ²Modern educational technology center of Kunming Medical University; ³Information Security College, Yunnan Police College

Background: Although the efficient compression results can be achieved by using the substitution algorithms. But in this way, the cost to code the dictionary should not be ignored. On the other hand, the entropy coding based on the context modeling technology can obtain the high compression efficiency by using the correlation among the bases in the genome sequence to construct the conditional probability distributions to drive the arithmetic encoder. In this paper, the Hilbert Curve is employed to map the genome sequence into 2-D image to discover more correlations among bases, which can improve the compression efficiency of the context modeling technology for the genome sequence compression.

Methods: Any operations of reducing dimensions can weak the correlations among neighboring symbols and verse vice. Namely, if the genome sequence can be mapped into signals with two dimensions, the more correlations among bases could be used for context modeling. One signal in dimension 1 can be mapped into dimension 2 by using Hilbert space filling curve. When the order of Hilbert curve is given, the curve is extended to 2-dimension space and the corresponding space can be filled sufficiently with the increment of orders.

Results: By comparing with the results of other algorithms at present, this one is better.

Conclusion: The experiments results indicate that the coding efficiency is better than results from any other compression algorithms for microbial genome sequence compression.

Properties of Optimized Context Weighting and Its Application for Genome Sequence Compression

Zhe M.W.¹, Liu A.J.², Chen M.²

¹Modern educational technology center of Kunming Medical University; ²Information Security College, Yunnan Police College

Background: In recent years, the ‘referential’ genome sequence compression algorithms have attracted the attention of more and more researchers for the reason that these algorithms can achieve high compression efficiency which both substitutional algorithms and entropy coding technologies cannot attain in the mammalian genome sequence compression. Meanwhile, these algorithms cooperate with the rapid DNA sequencing technology very well. When a new genome sequence is ready to be compressed, it is aligned with a reference sequence firstly. For those un-matching bases, the strategy that 2 bits for each base is utilized or some other coding schemes, such as the entropy coding methods, are suggested to compress those bases. Consequently, for those species whose genome sequence contain many repetitive fragments, the content need to be coded and transmitted will be greatly reduced and the high compression efficiency can be achieved.

Method: The context weighting is employed to enhance the compression efficiency. But Context weighting cannot be efficient by the reason of weighting cost. The properties of it are the key to reveal the context weighting. With the various similarities among counting vectors which are joined into weighting, the weighting costs will be different. If the counting vectors are similar, the corresponding weighting cost will be small.

Results: We give ten groups of 3-ary counting vectors for experiments. They are:

Conclusion: It is obviously that the weighting costs are at different values, which implies that the optimization of weights should be executed with the consideration of the similarity among counting vectors. The context weighting should depend on the counting vectors.

Flexible Job Shop Scheduling Focusing on Carbon Emissions

Meng Q.F.^1,2, Zhang L.X.¹, Fan Y.S.¹

¹State CIMS Engineering Research Center at Tsinghua University, Beijing 100084, China; ²The PLA Rocket Force Command College, Wuhan 430012, China

Objectives: The actual production is a real-time dynamic process in which some machines may always be processing, but others may have less tasks and in idle state for long time. Moreover, there are many uncertainties such as customer customization orders may come at any time, which requires scheduling system in machine arrangement considering real-time static machine load and dynamic load produced by possible future orders in order to meet the actual needs for saving energy and balancing the load of the machines to cut down carbon emission.

Methods: The optimization model is set up, which aims to minimize the total power consumption of all machines and a new hybrid particle swarm optimization (PSO) algorithm which integrates variable neighborhood search is proposed to solve the model in order to minimize carbon emissions. In order to optimize the power consumption, the actual load of the machine must be obtained and balanced. To solve this problem,a new least squares support vector machines (NLS-SVM) prediction method based on data correlation is presented which select a part of the data that have a strong correlation with the results to be input features at training stage. In order to select the appropriate model parameters, this paper proposes a parameter optimization method combining PSO, simulated annealing (SA) with tabu search method (TA) algorithm to optimize σ (the parameter of the kernel function) and C (the regularization parameter) to avoid effectively falling into local extremum points.

Results: Using the proposed algorithm to predict the load data of a factory production workshop in June 10, 2017, the average error of SVM-PSO proposed by Ch. Sudheer and that of NLS-SVM is 0.493 and 0.0174 respectively. Based on the prediction of load data, the hybrid particle swarm optimization (PSO) is used to optimize the power consumption. The experimental data show that this method can reduce the consumption of electricity by 20%, thus greatly reducing the carbon emission in the production process and realizing green production.

Conclusions: The method proposed in this paper can balance the machine burden and cut down electric energy by predicting machine load precisely and scheduling by focusing on decreasing carbon emission.

Acknowledgements: The work was supported by the National Science and Technology Supporting Plan of China No. 2012BAF15G01).

A Medicine Authenticity Identification Method Based on Blockchain Technology

Li J., Liu T.S., Wu Y.

School of Computer Science, Xi'an Shiyou University, Xi'an, China

Objectives: Medicine is a special commodity, and its quality and authenticity is vital to the protection of people's health and safety. This paper is to solve the problem of medicine authenticity identification based on blockchain technology.

Methods: Because of blockchain's various advantageous characteristics, such as decentralization, non-forgery, tamper-resistance, low operating costs, etc., the application potentiality and feasibility of blockchain in medicine authenticity identification has been researched. Collect data from the entire supply chain of medicine, including medicine prescription and its production method, dealers’ orders, third party logistics information, medical organizations’ purchase, and medicine distribution to patients. Based on blockchain technology, the data are stored in a decentralized, secure, sharing and tamper-resistant manner to maintain medicine data open and transparent.

Results: With the help of blockchain technology, oversight and management the whole process of medicine, including production, package, transportation and distribution, can prevent counterfeiting medicine, exchange medicine and false transaction.

Conclusions: Blockchain technology provides an effective solution for medicine authenticity identification.

Acknowledgements: Supported by Natural Science Foundation of China (Grant: 51707158)

Extraction, Purification and Antioxidant Activities of Polysaccharides from Phellinus igniarius

Yin X.^1,2, Zhang X.², Wan M.², You Q.^1,3

¹Jiangsu Provincial Engineering Laboratory for Biomass Conversion and Process Integration, Huaiyin Institute of Technology; Huaian, China 223001; ²Huaiyin Institute of Technology, School of Life Science and Food Engineering, Huaian, Jiangsu 223003, China; ³School of Chemical Engineering, Huaiyin Institute of Technology, Huaian, Jiangsu 223003, China

Objectives: Phellinus igniarius polysaccharides (PIPs) are regarded as the major bioactive constituents of P.igniarius. PIPs have several known bioactivities, such as immunomodulatory, antitumor, hepatoprotective and antioxidant. Ultrasonic-microwave synergistic extraction (UMSE) is a new technology which is the organic combination of ultrasonic and microwave techniques. It utilizes the high-energy effect of microwave and ultrasonic cavitation, and overcomes the shortcomings of conventional extraction. The characterizations of PIP were investigated.

Methods: UMSE is the organic combination of ultrasonic and microwave which makes full use of high-energy effect of microwave and ultrasonic cavitation, and it overcomes the shortcomings of conventional extraction, ultrasonic and microwave extraction. It realized low temperature atmospheric environment but fast, efficient extraction. PIPs were extracted by UMSE and the process was optimized by response surface methodology. The polysaccharides were purified by DEAE-Cellulose 52 and Sephadex G-100 chromatography, the monosaccharide compositions of polysaccharides were determined by gas chromatography, the antioxidant activities of various polysaccharides were investigated by measuring its scavenging ability on 2,2-diphenyl-1-picrylhydrazyl, hydroxyl radicals, ferric reducing activity power, and reducing power assay.

Results: The optimal conditions obtained by RSM for production of polysaccharides were: extraction time 28.5min, microwave power 120.6W and water to raw material ratio 25.7ml/g. Under these conditions, the yield of crude polysaccharides was 1.35±0.12%, which was close with the predicted yield value (1.41%). Two purified fractions, PIP-1 and PIP-2, were obtained from the crude polysaccharides through sequential purification step of DEAE-52 and Sephadex G-100 chromatography. The chemical constitutions and antioxidant activities of the PIP-1 and PIP-2 were studied. The main constituent monosaccharides were glucose, galactose and rhamnose. Monosaccharide content of polysaccharide is different in the PIP-1 and PIP-2. The PIP-1 and PIP-2 showed significant free radical scavenging activities in a dose-dependent manner, and PIP-2 showed significantly higher scavenging activity than PIP-1, the possible reason for this phenomenon may be that the sulfate content is different in PIP-1 and PIP-2.

Conclusion: The UMSE of PIPs is feasible and efficient. Monosaccharide content of polysaccharide is different in PIP-1 and PIP-2. PIP-1 and PIP-2 showed significantly higher scavenging activity.

Application of Adaptive Iterative Learning Control Based on Particle Swarm Optimization Algorithm in the Temperature Control of the Biogas Pool

Gu Q.¹, Hao X.H.², Pei T.T.², Zhang C.Y.¹, Duan J.¹

¹School of Computer and Communication, Lanzhou University of Technology, Lanzhou, 730050, China; ²School of Electrical and Information Engineering, Lanzhou University of Technology, Lanzhou, 730050, China

Objectives: According to the measured values of corresponding control the temperature of the methane tank, after each measurement, iterative learning control based on particle swarm optimization algorithm is used to calculate the temperature adjusting value of biogas digesters, approximation measurement value idea in predictive value, eventually achieve full control to achieve the temperature of the methane tank. And put forward the excess methane unified collection, sold the idea, enables the user to obtain a certain profit.

Methods: When solving the optimization problems, the main steps are divided into the following five steps:

Results: The Adaptive iterative learning control based on particle swarm optimization algorithm is used in the methane pool temperature regulation, can track the digester temperature very well, so in accordance with the implementation of the temperature of the methane tank to decide to adjust the temperature of biogas digester, to completely control the temperature of the methane tank effect, meet the biogas digesters produce effect was the highest purpose.

Conclusions: Iterative learning control based on particle swarm optimization algorithm for biogas pool temperature control, the intelligent algorithm was introduced into the digester temperature control, the idea is to measure the temperature of the methane tank, in accordance with the values measured, adjust the temperature of biogas, repeatedly using the iterative learning control based on particle swarm optimization algorithm to adjust the temperature, to correct the system reference the model role, and finally arrived in full control of the temperature of biogas digester.

Acknowledgements: Supported by a project grant from the natural science foundation of Gansu Province (Grand No. 1610RJZA024).

Correlation Study Between Proprioception and Isokinetic Strength of Knee Osteoarthritis

Yan W.¹, Murong J.Y.², Huang W.Z.¹, Wang Z.J.¹, Mai G.H.¹, Cui S.Y.³

¹Rehabilitation Institute of the Fifth people's Hospital of Foshan City, Foshan, China; ²Sports Health Care and Rehabilitation Department of Guangzhou Polytechnic of Sports, Guangzhou, China; ³Foshan Association of Rehabilitation Medicine, Foshan, China

Objectives: To observe the isokinetic strength of extensors and flexors around knee joint and estimate the correlation between proprioception and isokinetic strength in order to provide accurate evidences for forming plans and evaluating effectiveness of rehabilitation in knee osteoarthritis.

Methods: 30 patients, whose right knee meet the standard of knee osteoarthritis were randomly divided in the research. The patients were told to flex and extend the knee joint with maximum force in 30°/s angular velocity,while researchers observed the peak torque(PT),value of joint position sense(JPS)and hamstring/quadriceps ratio(H/Q) of knee joint with IsoMed 2000 isokinetic muscle strength testing system.

Results: PTs of the flexor and extensor in right knee were significantly lower than those of the left knee. There was significant difference in either flexor Pt or extensor Pt between the right and the left side (p<0.05). Compared with the flexor Pt and the extensor PT in left knee, there was no significant difference (p<0.05) while the flexor Pt and the extensor PT in right knee did differ significantly (p<0.05).The H/Q ratio of right knee was smaller than that of left knee,and they differ significantly (p<0.05) .Value of JPS in right knee was greater than that the left one. There was significant difference between them.

Conclusions: Imbalance of the neuromuscular strength around the knee and declines in both susceptiveness of afferent nerve and controllability of efferent nerve affects the stability of knee which result in decreasing dynamic joint position sensation.

Acknowledgements: Supported by a project grant from The Fund Project of Medical Research of Guangdong (Grand No. A2016627), Cultivating Fund Project for Key Specialties of Foshan (Grand No. Fspy3-2015027) and the 13th Five-Year Project of Key Specialties Construction of Foshan (Grand No. FSZDZK135033).

The Effect of Biofilm on Permeability of Porous Media

Zhao Y., Wu J.C., Shi F., Xu J.J., Shen Y.

Laboratory of Enhanced Oil Recovery of Education Ministry, Northeast Petroleum University, Daqing, China

Objectives: Currently, researchers have mainly focused on the field application of microbial enhanced oil recovery (MEOR) technology, while the theoretical study about the microbial oil displacement is relatively weak. This paper aims to study on the fermentation and the propagation mechanisms of microorganisms in the porous media.

Methods: Laboratory experiments and the theoretical models were used to understand the transport mechanisms of microorganisms and investigate the effect of the permeability of porous media on the transport. hom*ogeneous cores were used to study on the effect of microorganisms on the permeability of different rocks. Heterogeneous cores were constructed to study the transport of the microbial system during microorganisms injection. Taylor model and Clement model were used to compare with the experimental dates.

Results: The facultative anaerobes Cbj4 were short bacillus, and the length was about 2μm. SEM images in different permeability rocks showed that the microorganisms formed biofilm on the pore surface and the thickness was approximately equal to each other, which can explain why core permeability was changed and also help to explain the propagation mechanisms of microorganisms.

Conclusions: As a result of the action of biofilm, it improved the effect of development. This study provided fundamentals for future MEOR study and applications.

Acknowledgements: Supported by a project grant from the National Natural Science Foundation of China (Grand No. 51774088) and the Northeast Petroleum University Innovation Foundation For Postgraduate(YJSCX2016-008NEPU). The Corresponding Author is XU Jianjun.

Comprehensive Evaluation Method of Deep Profile Control and Flooding Effect Use the Biological Method

Wu J.C., Zhao Y., Xu J.J.

Key Laboratory of Enhanced Oil Recovery of Education Ministry, Northeast Petroleum University, Daqing, China

Objectives: The deep profile control and flooding technology has been widely used in the oilfield, while there is not a systemic, comprehensive method to evaluate deep-flooding effect. It aims to establish a new comprehensive evaluation method.

Methods: The authors selected eight representative evaluation parameters, excogitated the quantitative evaluation method and evaluation criteria of each parameter, then excogitated the weight of each parameter according to the parameter's relative importance, established the gray system comprehensive evaluation criterion and weight coefficient. The evaluation result divides better, good, medium, bad, worse five kinds.

Results: By used the Biological Method, taking a deep-flooding oil field block as an example to carry on the comprehensive evaluation, the results showed that each parameter had different effects on the deep-flooding effect. Through the software's generalized analysis, it could obtain the gray incidence coefficient matrix (0.7176, 0.8226, 0.7756, 0.6716, 0.5683), according to the biggest subordination principle, the gray incidence coefficient is 0.8226, the evaluation result is good.

Conclusions: The evaluation method could remove the influence of some interference factors, such as subjectivity; and make the evaluation from qualitative to quantitative, from single-index evaluation to multiple-index comprehensive evaluation. The relevant parameters are achieved quantification and normalization.

Acknowledgements: Supported by the Petro China Innovation Foundation (2016D-5007-0201), and the Northeast Petroleum University Innovation Foundation For Postgraduate (YJSCX2016-008NEPU). The Corresponding Author is XU Jianjun.

Research on Fast Biological Evolution Optimization Technology and Its Application in Intelligent Home

Jin M.¹, Xu J.J.², Yan L.M.²

¹School of Computer & Information Technology. Northeast Petroleum University, Daqing 163318, China; ²College of Electrical Information Engineering, Northeast Petroleum University, Daqing 163318, China

Objectives: Home energy optimization control is one of the important branches of home energy management system (HEMS), but the lack of effective intelligent optimization algorithm has restricted the practical application of home energy optimization control. The fast biological evolution optimization technology and its application in intelligent home.

Methods: In this paper, the HVAC system, energy storage system, distributed power supply and so on are added on the scheduling algorithm which is based on the minimization of household electric energy expenditure. And assume that the users can sell electricity to the grid according to their own conditions. With electricity cost and comfort level as the optimization indexes, established home energy optimization control model of the coordinated control of the hybrid energy, and put forward a intelligent solving method based on improved fast particle swarm optimization (APSO), work out the optimal time of electric appliance, the required power of each time in room temperature control system and the charge and discharge power of each period of the storage battery.

Results: The simulation results have shown that, in the case of considering the grid, distributed photovoltaic power generation, battery powered supply electricity collaborative, home energy optimization control strategy can satisfy the user comfort and minimize the power consumption, which has provided strong technical support to the popularity of home energy management system.

Conclusions: According to the time-of-use power price of purchase and sale, the objective of optimization control is to minimize the power consumption and the cost of comfort, established home energy optimization control model of the coordinated control of the hybrid energy, and put forward a intelligent solving method based on improved fast particle swarm optimization (APSO), work out the optimal time of electric appliance, the required power of each time in room temperature control system and the charge and discharge power of each period of the storage battery.

Acknowledgements: Supported by the National Natural Science Foundation of China (51774088). The Corresponding Author is YAN Limei.

Optimal PMU Placement Method Based on Shuffle Frog Leaping

Fu Zh.Y.¹, Xu J.J.²

¹School of Automation, Baotou Light Industry Vocational Technical College, Baotou, 014035, China; ²College of Electrical Information Engineering, Northeast Petroleum University, Daqing, 163318, China

Objectives: Currently, the optimal location of PMU determined by reliability index, using DE differential evolution algorithm and leapfrog algorithm SFLA improved hybrid optimization algorithm, taking PMU disposition smallest number as objective function. In order to ensure complete observability of power system conditions, improving the speed of convergence of the hybrid algorithm.

Methods: Primarily, considering the node failure rate as constraint in the optimization processes to guarantee the global optimal solution of the power system, at the same time to make the numbers of PMU least. Comparing considering the system failure rate and without considering the system failure rate for IEEE14 node-system and New England 39-node system, which shows that the program of considering system failure rate makes the reliability indices more stable and the hybrid algorithm, instead of the existing optimization methods, which can reduce the number of PMU configuration and achieve completely observability of the system, finally, through the simulation results of Daqing Oilfield grid Xianfeng hypervariable region, it verifies feasibility of the algorithm.

Results: Based on fully considering the reliability and economy, this article proposes the method of optimal PMU placement by combining the node failure rate and the completely observability of system as constraints. While trying to improve and combine Differential Evolution(DE) Algorithm and Shuffle Frog Leaping Algorithm(SFLA),use speed update strategy and global searching ability of DE algorithm to avoid low accuracy and easy to fall into the local optimum in dealing with problems, in order to improve the performance of the algorithm.

Conclusions: The outstanding advantages of this algorithm are not only to eliminate the number of PMU configuration but also to reduce the calculation time compared with other optimization algorithms. Make optimization procedure avoid local optimal solution so that solve efficiency is clearly improved, to achieve the purpose of the optimizing allocation.

Acknowledgements: Supported by a project grant from the National Natural Science Foundation of China (Grand No. 51774088). The Corresponding Author is XU Jianjun.

Comparison of Image Classification and Object Detection based on Medical Treatment

Yang J.H., Qi X.Q., Liu J.M.

International School, Beijing University of Posts and Telecommunications, Beijing, China

Objectives: Image classification and object detection are two widely used classification methods in computer vision. In this paper, the structural and functional comparison of these two classification methods will be conducted to find out the respective applications of these two classification methods.

Methods: In this paper, the structure and function of the image classification and object detection are mainly represented by Convolutional Neuron Network (CNN), R-CNN, and other algorithms.

Results: After comparing the structure and function of these algorithms, this paper found that the difference is that in image recognition, the algorithms are more focused on extracting the eigenvectors of the entire image to classify the image. In the object detection, the side focuses more on detecting the position of an object in the whole image or whether it is in the image.

Conclusions: This paper argues that in practical applications, image classification is more suitable for the macro-class classification of the entire image, and these images generally contain less object. Object Detection is more suitable for detecting the location of a number of objects in an image and the existence. For example, in clinical medicine, the object detection method can be used for the judgment of cancer and tumor cells.

Research and Development of New Environmental Protection Grouting Material

Wang H.B., Zhang Q.S., Liu R.T., Liu Y.K., Liu Y.N., Jiang P.

Research Center of Geotechnical and Structural Engineering, Shandong University, Jinan 250061, China

Objectives: The leakage of urban subway is a serious threat to the safety of subway operation. Grouting is a common method to solve seepage, but at present, the sealing effect of conventional cement material is poor and the chemical grout is effective but harmful to the environment. Therefore, it is time to develop a new type of environmental protection grouting materials.

Methods: Based on the characteristics of subway seepage, overall considered the material costs, carried out indoor experiments, taken cement as the main material, mixed with non-polluting and high performance polymer materials, a new type of environmental protection grouting material with high strength, strong impermeability and low cost is formed. Test its pollution, popularize and apply it in Qingdao metro.

Results: A new type of environmental protection grouting material have been developed, which is based on cement-based and is taking polymer material as auxiliary agent, and successfully applied in Qingdao Metro.

Conclusions: Polymer auxiliary material greatly improves the physical and chemical properties of cement, meets the requirements of subway seepage plugging. More importantly, it is environmental and has no pollution to the environment, therefore it is suitable for popularization and Application.

Acknowledgments: This work is support by the national key research and development plan of China (2016YFC0801600).

SPARQL Based Knowledge Graph Summarization for Bio-medical Big Data

Jiang Y.

School of Management, Beijing Normal University at Zhuhai, Zhuhai, China

Objectives: Aiming at conveniently investigating and using the huge amount of knowledge graph big data in bio-medical domain, it's essential to provide a knowledge graph summarization method, which can make the users know about the inner data structure before using.

Methods: The method is composed of a serials of pure SPARQL based querying procedures. It firstly searches for knowledge relations and constructs their knowledge graph summarization triples. Then knowledge graph summarization triples for each knowledge class are also extracted. Finally a knowledge graph summarization is built up based on those triples.

Results: The method is realized by Java at Cytoscape platform, and tested with some bio-medical data sources like Reactome, BioCyc and BioModel. The summarizing speed is around 6 to 11min with the coverage rate of 94.28%.

Conclusions: The method can make it without additional crawling and indexing work. However it cannot deal with the extraction of blank node based complex class.

Acknowledgements: Supported by the project grants from Science and Technology Plan Project of Guangdong Province (Grand No. 2017A040405004 and 2014A080804001), and Faculty Scientific Research Ability Promotion Plan of Beijing Normal University, Zhuhai.

Medical Image Analysis Based on Deep Learning

Dong S., Wang P.

School of Computer Science and Technology, Zhoukou Normal University, Zhoukou, China

Objectives: Deep learning is providing exciting solutions for medical image analysis problems, which has been applied to medical image detection, segmentation and registration, and computer-aided analysis.

Methods: This paper proposed an improved deep CNN (Convolutional Neural Network) to identify and detect the medical image.

Results: The experimental results show that the improved CNN can improve the performance for the application, which is more robust to the size of training sets than traditional CNN.

Conclusions: In this paper, we propose a framework of deep learning for analysis of medical image by using improved deep convolutional neural network (CNN) that is trained for classification of medical images. An intermodal dataset that contains twenty-four classes and five modalities is used to train the network. The learned features and the classification results are used to retrieve medical images. For retrieval, best results are achieved when class based predictions are used. An average classification accuracy of 98.67% is achieved for retrieval task. The proposed method is best suited to retrieve multimodal medical images.

Acknowledgements: Supported by project grant from the National Natural Science Foundation of China (Grant No. U1504602), China Postdoctoral Science Foundation (Grant No. 2015M572 141).

Response of Rice to Elevated UV-B Radiation at Different Nitrogen Levels: Photosynthesis, Yield and Quality

Yin H.¹, Zhan S.Y.², Qiao Y.³, Su B.Q.¹, Li J.D.¹

¹College of Agronomy, Shenyang Agricultural University, Shenyang 110161, China; ²Anshan Meteorological Administration, Anshan Liaoning 114004, China; ³Beijing Meteorological Service Center, Beijing 100089, China

Objective: Increasing UV-B radiation can disturb physiological and biochemical processes of plants and potential damage agricultural productivity. However, the roles of fertilizer in response of crops to enhanced UV-B radiation are still little known. Therefore, we evaluated the effects of UV-B radiation on photosynthesis, yield and quality of rice at different nitrogen levels, which would improve our understanding on effects of fertilizer application under elevated UV-B radiation.

Methods: We conducted the pot experiment with Shennong265 including six treatments, three nitrogen levels under two UV-B radiation levels. UV-B radiation was increased by 0.61W/m² using UV-B lamp with maximum output at 313nm.

Results: Enhanced UV-B radiation decreased photosynthetic parameters except the Ci led to decrease of yield and yield compounds and change of quality. Nitrogen improved Pn, Gs, Ls, Ci, rubisco and Cll content of leaves under elevated UV-B radiation. Grain weight, number of panicles per plant and grains per panicle were enhanced by increase of applied nitrogen under elevated UV-B radiation. However, fatty acid contents and eating quality of rice were decreased as the increasing dose of nitrogen under elevated UV-B radiation.

Conclusion: The nitrogen applying can alleviate damage of rice leaves photosynthetic by UV-B radiation and improved yield of rice. However, the quality of rice was not ameliorated by nitrogen level under elevated UV-B radiation.

Acknowledgement: This research was supported by National Natural Science Foundation of China (No. 31771673), Liaoning Science and Technology Project (No. 201501061), General project of Department of Education of Liaoning province (No. L2015486).

Antioxidant Capacity of Alfalfa Was Raised by drought During Flowering Period

Zhao T.H., Wu H.Y., Wang Y., Guo S.Y., Zhu X.J.

College of Agronomy, Shenyang Agricultural University, Shenyang, 110161 China

Introduction: Alfalfa, the mostly planted pasture in recent years, served an important part of pasture. In addition, antioxidant capacity reflected the ability to mitigate stress. Analyzing the antioxidant capacity of Alfalfa to drought would advance our ability to select the optimal species having high stress tolerance. Therefore, a field experiment was conducted to explore the effects of drought during flowering stage on the antioxidant capacity of Alfalfa.

Methods: A field experiment with three treatments as the control, the light drought, and the heavy drought, which were conducted during the flowering stage lasting 7days and replicated three times, were built. Four parameters including content of H2O2 and the production rate of O2⁻, relative electrolyte leakage and MDA content were explored to reflect the damage of drought stress, while seven parameters including the activity of protecting enzyme and the content of protecting materials were used to reflect the antioxidant capacity.

Results: Drought caused significant damages to Alfalfa represented by the increasing contents of H2O2, O2⁻, MDA and relative electrolyte leakage. The damages caused by drought were also accompanied by the increasing activities of protecting enzymes such as SOD, POD, and CAT. In addition, the drought also increased the contents of protecting materials except the carotenoid, indicating the increase of the antioxidant capacity.

Conclusion: Drought during the flowering stage damaged Alfalfa but also induced its autoprotection, which was reflected by the increasing antioxidant capacity.

Acknowledgement: This research was supported by National Natural Science Foundation of China (No. 31570404, 31500390, and 31771673), general scientific research project of Department of Education of Liaoning province (No. LSNYB201603).

Comparation of Commercial Red Blood Cell Lysis Agents for Preparation and Absolute Quantification of Leukocytes by Flow Cytometry

Liu Y.Y., Wang J.

National Institute of Metrology, Beijing, China

Objectives: Absolute quantification of leukocytes by flow cytometry is essential for the further sub-population analysis in clinical detection and has been daily carried out. The standardization of the operation process should be set up. The first part of this job is to investigate the influences of commercial red blood cell lysis reagents on the preparation and absolute quantification of leukocytes in human being's blood by flow cytometry.

Methods: The tested reagents included OptiLyse C(Coulter), LF-1000-Lyse and Flow(Harlan), Uti-Lyse (Dako), ACK Lysing Buffer (Gibco) and FACS Lysing Solution (BectonDickinson). In this test, the blood samples were obtained for 20 healthy adult subjects (ten males, ten females, age 20–60years). Microscopic Imaging flow cytometry (Merck, Imagestream Mark II) has been used to investigate the recovery amount, CD45 expression and cell shape change after each reagent action.

Results: Results showed that the preparation amount of leukocytes for each treatment differed greatly, although components of the tested reagents declared to be same. The red blood cell lysis reagents did not affect the apparent expression of CD45 on the leukocyte surface in this investigation. But the great shape change will happen to the leukocytes after treatment, even to cell disruption.

Conclusions: It can be concluded that lysis and fixation procedures can introduce different artefacts in the analysis and absolute quantification of leukocytes. The best way to avoid such side effect is to directly analyses the live whole blood.

Acknowledgements: Supported by the project grants from The National Key Research and Development Program of China [2017YFF0204600] [2017YFF0204601] and [2016YFF0202300].